Central Retinal Artery Occlusion: Local Intra-arterial Fibrinolysis versus Conservative Treatment, a Multicenter Randomized Trial

A review of central retinal artery occlusion: clinical presentation and management

“…The efficacy of such therapy varies between 6 and 49%, with a mean visual improvement rate of 15-21%. 5,49 Owing to the observational nature of much of the data, some report a superior outcome to natural history, 9 but overall these therapies do not alter the outcome more than the natural history of the disease. 43,[50][51][52] To date, there have been two randomized controlled trials investigating conservative treatments in the setting of CRAO.…”

“…However, the rate of adverse events was far higher in the local IA fibrinolysis compared with the standard therapy group (37% compared with 4.3%). 49 Thrombolysis can also be administered intravenously as per standard ischaemic stroke thrombolysis protocol. Intravenous administration has the theoretical advantage of easier access without the need for specialized interventional radiology set-up and reduced risk of haemorrhagic complications.…”

“…7,49 The published observational data suggested that the risk of cerebral stroke and haemorrhage was low. This is in stark contrast to the findings of both randomized controlled trials, which demonstrated that the risk of haemorrhage is certainly not negligible and occurs in about 10% of cases.…”

“…This is in stark contrast to the findings of both randomized controlled trials, which demonstrated that the risk of haemorrhage is certainly not negligible and occurs in about 10% of cases. 7,49 Thus, future studies must factor the potential of adverse events, which at times may be life threatening and balance this with the eyesight-preserving benefits of tPA delivered within as short a time window as possible.…”

Hyperbaric Oxygen Treatment in Acute Visual Loss Due to Retinal Artery Occlusion: Case Report

“…4,5 Ayrıca retinal arter tıkanıklıklarında hiperbarik oksijen tedavisinin etkili bulunduğuna dair çalışmalar da bulunmaktadır. [6][7][8] Bizim olgumuzda da hastaya 16 seans HBOT uygulanmıştır.…”