Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient

Türkçüoğlu, Peykan; Işık, Ahmet Turan; Deniz, Nurettin; Turgut, Burak; Kan, Elif Kilic

doi:10.1007/s10792-007-9084-3

Cited by 15 publications

(8 citation statements)

References 8 publications

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“…In one case, acute amaurosis was due to CRAO, and treatment with PSL and cyclophosphamide was unsuccessful [12]. To the best of our knowledge, 11 cases of CSS complicated by CRAO have been reported previously: 8 with unilateral CRAO [13][14][15][16][17][18][19][20] and 2 with bilateral CRAO [21,22]. As summarized in Table 1, 5 of 12 patients (including our patient) were positive for MPO-ANCA.…”

Section: Discussionmentioning

confidence: 79%

Churg–Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature

et al. 2011

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A 68-year-old man was admitted with rapid visual loss. Churg-Strauss syndrome (CSS) was diagnosed, based upon the symptoms of asthma, eosinophilia, interstitial pneumonitis, and positive myeloperoxidase-anti neutrophil cytoplasmic antibody (MPO-ANCA). Light reflexes were absent and vision was completely lost in both eyes. Bilateral central retinal artery occlusion (CRAO) was observed by fluorescence angiography. Steroid pulse along with an anticoagulant improved the visual acuity to light perception and hand motion. CSS-associated CRAO should be considered when acute visual loss occurs.

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Section: Discussionmentioning

confidence: 79%

Churg–Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature

et al. 2011

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“…There have been a few previous reports about CSS patients without ANCA who developed CRAO. [134] These cases may indicate that the ANCA status is not a useful criterion for the classification of ocular inflammation in CSS.…”

Section: Discussionmentioning

confidence: 99%

“…[1234] It might be due to low-dose systemic corticosteroids (prednisolone ≤ 60 mg) or delay in performing steroid pulse therapy. In the present patient, steroid pulse therapy had already been started on the day before the occurrence of CRAO and the final visual acuity was 20/30.…”

Section: Discussionmentioning

confidence: 99%

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A case of Churg-Strauss syndrome and central retinal artery occlusion with good visual recovery

Kamata

Hashizume

Kaneko

et al. 2013

Indian J Ophthalmol

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Here we report a case of Churg–Strauss syndrome (CSS) and central retinal artery occlusion (CRAO), with good visual recovery. A 58-year-old Japanese man with CSS experienced acute painless loss of vision in his right eye. CRAO was diagnosed by fundoscopic findings (retinal whitening with a cherry-red spot). Steroid pulse therapy (methylprednisolone at 1 g daily for 3 days) followed by combined treatment with prednisolone (30 mg/day) and cyclophosphamide (150 mg/day) was administered; his visual acuity recovered to 20/30 in 1 month, and no recurrence has occurred for 1 year. Steroid pulse therapy may be effective for CRAO in CSS patients.

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“…Ophthalmologic presentations include sudden visual loss due to retinal artery occlusion [22,23] and nodular conjunctival involvement [24]. Sudden sensorineural hearing loss at onset has also been described [25].…”

Section: Clinical Featuresmentioning

confidence: 99%

Churg-Strauss syndrome: 2005–2008 update

Grau

2008

Curr Rheumatol Rep

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Churg-Strauss syndrome (CSS) is a rare necrotizing small-vessel vasculitis associated with eosinophil-rich granulomatous inflammation of tissues and vessels and is also associated with asthma and eosinophilia. Epidemiologic studies continue to show that CSS is the rarest of the necrotizing small-vessel vasculitides. However, it is not possible to know with any certainty if there has been an increase in incidence. There has been an attempt to divide the patients with CSS into an antineutrophil cytoplasmic antibody-positive and cytoplasmic antibody-negative group. The former group has an increased frequency of renal involvement, parenchymal pulmonary disease, constitutional symptoms, and peripheral and central nervous system involvement, whereas the latter group has more frequent cardiac disease. The role of eosinophils and antineutrophil cytoplasmic antibodies remains poorly defined but provocative. Leukotriene receptor antagonists do not appear to induce CSS but facilitate the tapering of glucocorticoids, which unmasks the condition. Glucocorticoids and cyclophosphamide remain the foundation of treatment for vasculitis, but there are other promising and less toxic alternatives on the horizon.

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Central retinal artery occlusion in an ANCA negative Churg-Strauss syndrome patient

Abstract: Central retinal artery occlusion can occur in ANCA negative Churg-Strauss syndrome. Patients with this diagnosis should be considered for prophylactic high dose corticosteroid, regardless of their ANCA status.

Cited by 15 publications

References 8 publications

Churg–Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature

Churg–Strauss syndrome complicated by central retinal artery occlusion: case report and a review of the literature

A case of Churg-Strauss syndrome and central retinal artery occlusion with good visual recovery

Churg-Strauss syndrome: 2005–2008 update

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