Central receptor binding and cardiovascular effects of GABA analogues in the cat

Matheson, G.K.; Freed, Elisabeth H.; Tunnicliff, G.

doi:10.1016/0306-3623(87)90010-3

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…Binding of trans-UCA (cis-UCA not studied) to rat cortical membrane GABA receptors has been reported, but it was much weaker than that of GABA (Matheson et al, 1987). Our data also show slight displacement of bound GABA by trans-UCA, but a clearly stronger effect by cis-UCA.…”

supporting

confidence: 62%

“…Because of its structural relationship to γ-amino butyric acid (GABA), UCA has also been included in screening of in vivo biologic activity mediated by the GABA receptors, found typically in the central nervous system, and substantial effectiveness was observed (Matheson et al, 1986(Matheson et al, , 1987. Direct competition binding studies with UCA have been reported only on α 2 -and imidazol(in)e receptors 1 (no binding), and GABA (weak binding with trans-UCA; cis-isomer not studied) (Tunnicliff et al, 1985;Matheson et al, 1987).…”

Section: Urocanic Acid Binds To Gaba But Not To Histamine (H 1 H 2 mentioning

confidence: 99%

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Urocanic Acid Binds to GABA but not to Histamine (H1, H2, or H3) Receptors

Laihia¹,

Jansén²,

Attila

et al. 1998

Journal of Investigative Dermatology

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supporting

confidence: 62%

Section: Urocanic Acid Binds To Gaba But Not To Histamine (H 1 H 2 mentioning

confidence: 99%

Urocanic Acid Binds to GABA but not to Histamine (H1, H2, or H3) Receptors

Laihia¹,

Jansén²,

Attila

et al. 1998

Journal of Investigative Dermatology

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“…Urocanic acid (UCA), an important mediator of UV-induced immunosuppression, was found to be an inhibitor of GABA A receptors ( Matheson et al., 1987 ) and to interfere with agonist binding to GABA A receptors in the brain membrane ( Uusi-Oukari et al., 2000 ). These studies demonstrate the possibility that high levels of urocanic acid may interfere with GABA binding to receptors in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System

Tian

Xing

Zheng

et al. 2021

Front. Cell. Infect. Microbiol.

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Postpartum depression (PPD) is a mental disorder that affects pregnant women around the world, with serious consequences for mothers, families, and children. Its pathogenesis remains unclear, and medications for treating PPD that can be used during lactation remain to be identified. 919 syrup (919 TJ) is a Chinese herbal medicine that has been shown to be beneficial in the treatment of postpartum depression in both clinical and experimental studies. The mechanism of action of 919 TJ is unclear. 919 syrup is ingested orally, making the potential interaction between the drug and the gut microbiome impossible to ignore. We therefore hypothesized that 919 syrup could improve the symptoms of postpartum depression by affecting the structure and function of the intestinal flora, thereby altering hippocampal metabolism. We compared changes in hippocampal metabolism, fecal metabolism, and intestinal microflora of control BALB/c mice, mice with induced untreated PPD, and mice with induced PPD treated with 919 TJ, and found that 4-aminobutyric acid (GABA) in the hippocampus corresponded with PPD behaviors. Based on changes in GABA levels, multiple key gut bacterial species (Mucispirillum schaedleri, Bifidobacterium pseudolongum, Desulfovibrio piger, Alloprevotella tannerae, Bacteroides sp.2.1.33B and Prevotella sp. CAG:755) were associated with PPD. Metabolic markers that may represent the function of the intestinal microbiota in mice with PPD were identified (Met-Arg, urocanic acid, thioetheramide-PC, L-pipecolic acid, and linoleoyl ethanolamide). The relationship between these factors is not a simple one-to-one correspondence, but more likely a network of staggered functions. We therefore believe that the composition and function of the entire intestinal flora should be emphasized in research studying the gut and PPD, rather than changes in the abundance of individual bacterial species. The introduction of this concept of “GutBalance” may help clarify the relationship between gut bacteria and systemic disease.

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“…For instance, microbial biotransformation of isoflavones to aglycones and equol improved the antiosteoporotic and anti-inflammatory effect of fermented soymilk (Chiang & Pan, 2011;Di Cagno et al, 2010). Moreover, lactic acid bacteria have been employed to produce ACE-inhibitory peptides and c-aminobutyric acid (GABA) in foods, both useful in the prevention and treatment of hypertension (Kono & Himeno, 2000;Matheson, Freed, & Tunnicliff, 1986;Ricci, Artacho, & Olalla, 2010). In contrast, fermentation has not been extensively applied for production of antihypertensive compounds in legumes, with the exception of soybean (Juan & Chou, 2010).…”

Section: Introductionmentioning

confidence: 95%

Antioxidant and antihypertensive properties of liquid and solid state fermented lentils

et al. 2013

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The effect of liquid (LSF) and solid state fermentation (SSF) of lentils for production of water-soluble fractions with antioxidant and antihypertensive properties was studied. LSF was performed either spontaneously (NF) or by Lactobacillus plantarum (LP) while SSF was performed by Bacillus subtilis (BS). Native lactic flora in NF adapted better than L. plantarum to fermentative broth and BS counts increased 4.0 logCFU/g up to 48 h of SSF. LSF water-soluble fractions had higher (P ≤ 0.05) free amino groups, GABA content, antioxidant and angiotensin I-converting enzyme inhibitory (ACEI) activities than SSF. In addition, GABA and ACEI activity of LSF increased in a time-dependent manner. Proteolysis by BS was limited, with slight changes in free amino groups, while GABA, total phenolic compounds and antioxidant capacity increased throughout fermentation. Higher antihypertensive potential was observed in NF (96 h) characterised by the highest GABA content (10.42 mg/g extract), ACE-inhibitory potency (expressed as IC(50)) of 0.18 mg protein/ml and antioxidant capacity of 0.26 mmol Trolox equivalents/g extract. Therefore, water-soluble fermented lentil extracts obtained by LSF are particularly promising as functional ingredients in preventing hypertension.

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Central receptor binding and cardiovascular effects of GABA analogues in the cat

Cited by 11 publications

References 20 publications

Urocanic Acid Binds to GABA but not to Histamine (H1, H2, or H3) Receptors

Urocanic Acid Binds to GABA but not to Histamine (H1, H2, or H3) Receptors

919 Syrup Alleviates Postpartum Depression by Modulating the Structure and Metabolism of Gut Microbes and Affecting the Function of the Hippocampal GABA/Glutamate System

Antioxidant and antihypertensive properties of liquid and solid state fermented lentils

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