Central prolactin binding site densities change seasonally in an adult male passerine bird (Junco hyemalis)

Smiley, Kristina O.; Buntin, John D.; Corbitt, Cynthia; Deviche, Pierre

doi:10.1016/j.jchemneu.2020.101786

Cited by 8 publications

(4 citation statements)

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“…The mechanism by which male doves may upregulate PRLR remains unclear, though testosterone may play a possible role, as castration significantly reduces prolactin binding in the rat brain (Salais-López et al, 2018). Our findings highlight the need to study prolactin dynamics in both sexes, as most studies of PRL/R expression in birds to date only included one sex or did not compare sex differences (Buntin and Buntin, 2014;Chaiseha et al, 2012;Ramesh et al, 2000;Smiley et al, 2021Smiley et al, , 2020.…”

Section: Sex Differences In Prl and Prlr Gene Expressionmentioning

confidence: 91%

“…The copyright holder for this preprint (which this version posted July 14, 2021. ; https://doi.org/10.1101/2021.07.13.452208 doi: bioRxiv preprint some hypothalamic nuclei, and hypothalamic responsiveness to prolactin (measured via STAT5 phosphorylation downstream of the PRLR) increases with reproductive experience (Anderson et al, 2006;Sjoeholm et al, 2011). In birds, brain responsiveness to prolactin increases during breeding compared to non-breeding individuals of multiple species (Buntin and Buntin, 2014;Smiley et al, 2021), and prolactin binding varies seasonally, including during breeding (Smiley et al, 2020). However, how hypothalamic responsiveness to prolactin varies during transitions within the breeding cycle remains less studied.…”

Section: Introductionmentioning

confidence: 99%

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Prolactin and prolactin receptor expression in the HPG axis and crop during parental care in both sexes of a biparental bird (Columba livia)

Farrar¹,

Harris²,

Austin³

et al. 2021

Preprint

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During breeding, multiple circulating hormones, including prolactin, facilitate reproductive transitions in species that exhibit parental care. Prolactin underlies parental behaviors and related physiological changes across many vertebrates, including birds and mammals. While circulating prolactin levels often fluctuate across breeding, less is known about how relevant target tissues vary in their prolactin responsiveness via prolactin receptor (PRLR) expression. Recent studies have also investigated prolactin (PRL) gene expression outside of the pituitary (i.e., extra-pituitary PRL), but how PRL gene expression varies during parental care in non-pituitary tissue (e.g., hypothalamus, gonads) remains largely unknown. Further, it is unclear if and how tissue-specific PRL and PRLR vary between the sexes during biparental care. To address this, we measured PRL and PRLR gene expression in tissues relevant to parental care, the endocrine reproductive hypothalamic-pituitary- gonadal (HPG) axis and the crop (a tissue with a similar function as the mammalian mammary gland), across various reproductive stages in both sexes of a biparental bird, the rock dove (Columba livia). We also assessed how these genes responded to changes in offspring presence by adding chicks mid-incubation, simulating an early hatch when prolactin levels were still moderately low. We found that pituitary PRL expression mirrored changes in plasma prolactin levels, and detected extra-pituitary PRL in the hypothalamus, gonads and crop. Hypothalamic and gonadal PRLR expression also changed as birds began incubation. Crop PRLR expression correlated with plasma prolactin, peaking when chicks hatched. Hypothalamic and gonadal PRL and PRLR gene expression differed significantly in response to offspring cues, even when plasma prolactin levels did not differ. We also found sex differences in PRL and PRLR that suggest gene expression may allow males to compensate for lower levels in prolactin by upregulating PRLR in all tissues. Overall, this study advances our understanding of how tissue-specific changes in responsiveness to parental hormones may differ across key reproductive transitions, in response to offspring cues, and between the sexes.

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Section: Sex Differences In Prl and Prlr Gene Expressionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prolactin and prolactin receptor expression in the HPG axis and crop during parental care in both sexes of a biparental bird (Columba livia)

Farrar¹,

Harris²,

Austin³

et al. 2021

Preprint

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show abstract

“…European quail develop increased body mass and food intake after prolactin injection, suggesting that prolactin in this species may play a role in body mass seasonality (Boswell et al, 1995 ). In the avian hypothalamus, prolactin binding efficiency in multiple nuclei is seasonal with a general decrease in summer animals, though it is unclear if this is due to increased prolactin receptor occupancy or a change in its expression (Smiley et al, 2020 ). In female bantams, photostimulatory egg laying is unaffected by immunization against prolactin, though delays or prevents the onset of incubation behavior (March et al, 1994 ).…”

Section: Seasonality Of Prolactin Signaling In Birdsmentioning

confidence: 99%

Seasonality of prolactin in birds and mammals

Stewart

Marshall

2022

J Exp Zool Pt A

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In most animals, annual rhythms in environmental cues and internal programs regulate seasonal physiology and behavior. Prolactin, an evolutionarily ancient hormone, serves as a molecular correlate of seasonal timing in most species.Prolactin is highly pleiotropic with a wide variety of well-documented physiological effects; in a seasonal context prolactin is known to regulate annual changes in pelage and molt. While short-term homeostatic variation of prolactin secretion is under the control of the hypothalamus, long-term seasonal rhythms of prolactin are programmed by endogenous timers that reside in the pituitary gland. The molecular basis of these rhythms is generally understood to be melatonin dependent in mammals. Prolactin rhythmicity persists for several years in many species, in the absence of hypothalamic signaling. Such evidence in mammals has supported the hypothesis that seasonal rhythms in prolactin derive from an endogenous timer within the pituitary gland that is entrained by external photoperiod. In this review, we describe the conserved nature of prolactin signaling in birds and mammals and highlight its role in regulating multiple diverse physiological systems. The review will cover the current understanding of the molecular control of prolactin seasonality and propose a mechanism by which longterm rhythms may be generated in amniotes.

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“…Since nesting behaviour is under the control of steroid hormones [77], the identified active brain regions involved in nesting behaviour may express steroid receptors, that contributes to nonapeptide release and control of parental care. The incubation period is mainly regulated by prolactin and its receptor (see earlier), which is abundant in the POM, VMH, PVN, LH, Tu, and suprachismatic nucleus (SCN), but there are temporal differences in receptor distribution between species with seasonal and opportunistic breeding [75], [244].…”

Section: Neuronal Regulation Of Parental Behaviourmentioning

confidence: 99%

The neurogenetic background of parental care

Fazekas¹

2020

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ARC -nucleus arcuatus BGI -Beijing Genomics Institute blAmy -basolateral amygdala BSA -bovine serum albumin BST -bed nucleus of the stria terminalis BSTl -lateral subdivision of bed nucleus of stria terminalis BSTm -medial part of the bed nucleus of stria terminalis BSTmd -medio-dorsal subdivision of bed nucleus of stria terminalis BSTmv -medio-ventral subdivision of bed nucleus of stria terminalis Cb -cerebellum CDL -dorsolateral corticoid area cDNA -copy DNA CHAT -choline-o-acetyltransferase co -optic chiasm CLDN1 -caludin 1 CP -posterior commissure CRYM -crystallin mu CT -cycle threshold D1 -type 1 dopamine receptor D2 -type 2 dopamine receptor DA -dopamine DAT -dopamine transporter DEG -differentially expressed gene dmSt -dorsomedial striatum E -entopallium EA -extended amygdala EG -experimental group ERa -estrogen alpha receptor FA -frontoamygdaloid tract FC -fold change FLM -longitudinal medial tract Fos-ir -Fos immunoreactive FRL -lateral reticular formation GABA -gamma aminobutyric acid GAPDH -glyceraldehyde 3-phosphate dehydrogenase GCt -central gray GLM -generalised linear model GnIH -gonadotropin-inhibitory hormone GOI -gene of interest GP -globus pallidus HA -apical hyperpallium HDC -Histidine decarboxylase HF -hippocampal formation Hip -hippocampus HPRT -hypoxanthine phosphoribosyltransferase HVC -high vocal centre IAPP -islet amyloid polypeptide ICo -intercollicular nucleus

show abstract

Central prolactin binding site densities change seasonally in an adult male passerine bird (Junco hyemalis)

Cited by 8 publications

References 36 publications

Prolactin and prolactin receptor expression in the HPG axis and crop during parental care in both sexes of a biparental bird (Columba livia)

Prolactin and prolactin receptor expression in the HPG axis and crop during parental care in both sexes of a biparental bird (Columba livia)

Seasonality of prolactin in birds and mammals

The neurogenetic background of parental care

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