Central precocious puberty, functional and tumor-related

Soriano‐Guillén, Leandro; Argente, Jesús

doi:10.1016/j.beem.2019.01.003

Cited by 64 publications

(55 citation statements)

References 91 publications

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“…Treatment with GnRH analogs is safe and well tolerated [9]. Preliminary treatment assessment shows a positive effect on overall growth.…”

Section: Treatmentmentioning

confidence: 98%

“…It often occurs in patients with type 1 neurofibromatosis. In such cases its location in the optic chiasm and hypothalamus significantly increases the risk of CPP [23].…”

Section: Septo-optic Dysplasiamentioning

confidence: 99%

“…The prevalence of CPP increases following cranial exposure to radiation due to tumors or leukemia. Low doses of radiation (18)(19)(20)(21)(22)(23)(24) used in the prophylactic treatment of the CNS in acute lymphoblastic leukemia and moderate doses (25.0-47.5 Gy) used in the treatment of brain tumors in children increase the risk of CPP [1]. Radiation therapy can destroy GABA-secreting neurons, leading to decreased GABA concentration and a loss of the inhibitory effect on the GnRH pulse generator.…”

Section: Previous Radiotherapymentioning

confidence: 99%

“…Perinatal hypoxic-ischemic encephalopathy with cerebral palsy (which is a complication of encephalopathy) is another risk factor for CPP [23]. This is probably due to an early brain development disorder secondary to hypoxia.…”

Section: Perinatal Hypoxic-ischemic Encephalopathymentioning

confidence: 99%

“…Idiopathic precocious puberty is significantly less prevalent among boys and CPP is mostly the result of lesions in the CNS [1]. Of note, the number of cases diagnosed with the idiopathic form of the disease is steadily decreasing, which is mainly related to the detection of mutations that cause CPP [9]. However, genetic testing for these mutations is still rarely performed.…”

Section: Idiopathic Precocious Pubertymentioning

confidence: 99%

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Central precocious puberty - etiology with particular consideration of neurological causes

2020

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Central precocious puberty (CPP) is a rare disease of poorly understood etiology. The cause is mostly idiopathic. However, congenital and acquired structural changes in the central nervous system are also involved. Prevalent organic changes in the central nervous system, especially among boys, prompt imaging assessment in each case of CPP. In addition, genetic and environmental factors have been reported. Safe and effective treatment is available. The time of treatment implementation is crucial to the successful outcome. Proper diagnosis and treatment make it possible to avoid a number of complications of untreated CPP. There are only a few studies analyzing the prevalence and risk factors for the disease. The aim of this paper is to discuss the current causes of CPP with particular consideration of neurological aspects.

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“…Treatment with GnRH analogs is safe and well tolerated [9]. Preliminary treatment assessment shows a positive effect on overall growth.…”

Section: Treatmentmentioning

confidence: 98%

“…It often occurs in patients with type 1 neurofibromatosis. In such cases its location in the optic chiasm and hypothalamus significantly increases the risk of CPP [23].…”

Section: Septo-optic Dysplasiamentioning

confidence: 99%