Central oxytocin enhances antinociception in the rat

Yang, Jun; Yu, Yang; Chen, Jianmin; Liu, Wenyan; Wang, Chenghai; Lin, Bao-Chen

doi:10.1016/j.peptides.2007.03.003

Cited by 90 publications

(79 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This effect is consistent with studies of both mechanical and thermal somatic nociception in rats. [8][9][10] It is likely that this effect is largely due to inhibition of the sensory portion of the reflex circuit, because our own data and other studies have observed OXYinduced inhibition of evoked dorsal horn neuron activity. 19,20 Our maximal OXY dose of 1.5 μg is well below the level previously reported to consistently produce nonspecific motor effects in rats.…”

Section: Discussionmentioning

confidence: 57%

See 1 more Smart Citation

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Engle

Ness

Robbins

2013

Obstetric Anesthesia Digest

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 57%

“…The ability of intrathecal OXY to produce somatic antinociception or analgesia has been demonstrated in naïve rats [8][9][10] following acute inflammation 10 and neuropathic injury. 11 Further, stimulation of the PVN increases OXY levels in the cerebrospinal fluid and produces antinociception.…”

Section: Introductionmentioning

confidence: 99%

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Engle

Ness

Robbins

2013

Obstetric Anesthesia Digest

View full text Add to dashboard Cite

show abstract

“…Results of several studies have shown that oxytocin has analgesic effect 12 and part of analgesic effect of that is related to inhibition of spinal glutamatergic transmission 13 . One of the possible mechanisms for the analgesic effect of oxytocin in normal animals is the action of oxytocin on its G protein receptor which leads to metabolization of intracellular calcium and subsequently a nonspecific cation channel open and potassium channel close 14,15 .…”

Section: Discussionmentioning

confidence: 99%

Effects of oxytocin and oxytocin receptor antagonist atosiban on nociception and morphine analgesia in rats

Taşkıran

Özdemir²,

Güneş³

et al. 2017

Cumhuriyet Medical Journal

View full text Add to dashboard Cite

SUMMARYObjective: Oxytocin is a peptide-based hormone released from the supraoptic nucleus and paraventricular nucleus in the hypothalamus and consisting of nine amino acids. It has been shown that oxytocin may have an effect on opiate receptors. Atosiban is a oxytocin receptor antagonist. Our aim in this study was to investigate the effects of oxytocin and atosiban on nociception and morphine analgesia. Method: In our study, 48 Wistar Albino 230-260 g male rats were used. The animals were divided into eight groups (control, 200 μg/kg oxytocin, 3 mg/kg atosiban, oxytocin+ atosiban, 5 mg/kg morphine, morphine+ oxytocin, morphine+atosiban and morphine+ oxytocin+ atosiban). Serum physiologic to the control group, oxytocin and atosiban were given intraperitoneally (i.p.) at the indicated doses to the other groups. Morphine was administered subcutaneously (s.c.). Analgesic effects were assessed by hot plate and tail flick analgesia tests. The resulting analgesic effect was measured and recorded at the 15th, 30th, 60th, 90th and 120th minutes. Assessment of analgesic effect was formulated as % analgesia (MPE) (% analgesia = 100x [post drug reaction time-pre drug reaction time]/ [cut off time-pre drug reaction time]). Results: Oxytocin showed analgesic activity (p<0,05). Atosiban showed hyperalgesic activity and decreased the analgesic activity of oxytocin when given with oxytocin (p<0,05). Oxytocin increased the analgesic activity of morphine (p<0.05). In addition, although atosiban did not alter the analgesic activity of morphine, morphine analgesia increased by oxytocin was reduced (p<0.05). Conclusions: According to these results, it can be said that although atosiban does not change on the analgesic effect of morphine alone, it blocks the effect of oxytocin on morphine analgesia. Keywords: Atosiban, oxytocin, nociception, morphine analgesia, analgesia tests ÖZET Amaç: Oksitosin, hipotalamusta supraoptik çekirdek ve paraventrikülerçekirdeklerden salınan, dokuz amino asitten oluşan, peptid yapılı bir hormondur. Oksitosin'in opiyat reseptörleri üzerinde etkili olabileceği gösterilmiştir. Atosiban, oksitosinin reseptör antagonistidir. Bu çalışmada amacımız, oksitosin ve atosibanın nosisepsiyon ve morfin analjezisi üzerine etkilerini araştırmaktır.

show abstract

“…OT'nin i.s.v. veya intratekal verilmesinin ağrı eşiğini artırdığı, buna karşın anti-OT serumunun santral yolla uygulanmasının da ağrı eşiğini düşürdüğü gösterilmiştir (23). Başka araştırmacılar periferik OT'nin ağrı eşiğini yükselttiğini, ancak bunun yüksek dozlarda gerçekleştiğini belirtmektedirler (24).…”

Section: Tartişma Ve Sonuçunclassified

“…Ancak, bizim çalışmamızdaki sonuçlara benzer şekilde, düşük dozlarda periferik uygulanan OT'nin ağrı eşiğini etkilemediği-ni gösteren araştırmacılar da bulunmaktadır (23). OT antagonisti olan atosibanın intratekal verilmesiyle yapılan hiperaljezi modelinde endojen ve ekzojen OT'nin spinal korda opioid reseptörler aracılığıyla antinosisepsiyon sağlandığı görülmüştür ( 25).…”

Section: Tartişma Ve Sonuçunclassified

Siçanlarda yanikla indüklenen anksiyete artisina ve agri algisina santral ve periferik uygulanan oksitosinin etkisi

Memi¹

2011

mpj

View full text Add to dashboard Cite

Central oxytocin enhances antinociception in the rat

Cited by 90 publications

References 21 publications

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Effects of oxytocin and oxytocin receptor antagonist atosiban on nociception and morphine analgesia in rats

Siçanlarda yanikla indüklenen anksiyete artisina ve agri algisina santral ve periferik uygulanan oksitosinin etkisi

Contact Info

Product

Resources

About