Central odontogenic fibroma: An updated systematic review of cases reported in the literature with emphasis on recurrence influencing factors

Pontes, Flávia Sirotheau Corrêa; Souza, Lucas Lacerda de; Paula, Lorena Paula de; Neto, Elieser de Melo Galvão; Gonçalves, Priscilla Flores Silva; Pontes, Hélder Antônio Rebelo

doi:10.1016/j.jcms.2018.07.025

Cited by 24 publications

(29 citation statements)

References 38 publications

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“…Similar to the nature of COF and CGCG, recurrences have been observed with slightly higher rate in the aggressive behavior, ill-defined margin and multilocular lesions. 1,10,11 Odell et al, stated that the lesion tends to behave like the CGCG much more than the COF due to its prevalence and behavior. 21 Histo-pathologically, several cases of the HCOF-CGCG were found to be contained as densely collagenous to fibromyxoid stroma with several nests of inactive odontogenic epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…The central odontogenic fibroma (COF) is an uncommon disease found in gnathic area. 1 In 2017, WHO defines it as an ectomesenchymal tumor with a mature fibrous connective tissue lesion, which usually combines with an odontogenic epithelium. 2 It can occur in wideranging age distribution and slight female predilection affecting relatively equal frequency in both jaws.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma Like Lesion ; A Case Report and Review of the Literature

Vijintanawan

Kumar

Aittiwarapoj

2019

Smj

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The combination of central odontogenic fibroma and central giant cell granuloma is extremely rare and has been reported in only 46 cases worldwide in previous articles. The lesion is called a hybrid central odontogenic fibroma with central giant cell granuloma like lesion (HCOF-CGCG) due to a histopathological characteristics of multinucleated giant cell and odontogenic epithelium in fibro-cellular background. We report a case of HCOF-CGCG in a 27-year old Thai male patient who was identified as the first case in Thailand. Radiographic examination showed a well-defined radiolucency lesion at posterior mandibular area. Enucleation and curettage were done and microscopic study revealed a fibro-cellular proliferating tissue containing numerous strands, cord of odontogenic epithelium, and numerous multinucleated giant cells. This report also included a literature review of the previous 45 cases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma Like Lesion ; A Case Report and Review of the Literature

Vijintanawan

Kumar

Aittiwarapoj

2019

Smj

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“…In the maxilla, COF occurs most frequently in the anterior region, followed by the premolar and the molar regions. In the mandible, this is reversed [ 6 ]. The incidence is highest in individuals aged 10 to 39 years [ 4 – 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…In some instances, COF can exhibit mixed radiolucency/radiopacity, with poorly defined or diffuse borders [ 4 ]. COF may be associated with unerupted or displaced teeth and root resorption [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Amyloid Variant of Central Odontogenic Fibroma in the Mandible: A Case Report and Literature Review

2020

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Patient: Male, 35-year-old Final Diagnosis: Central odontogenic fibroma Symptoms: Asymptomatic Medication:— Clinical Procedure: Enucleation • surgery removal Specialty: Dentistry Objective: Rare disease Background: Odontogenic fibroma is a rare mesenchymal odontogenic tumor. It can be classified as central odontogenic fibroma (COF) or peripheral odontogenic fibroma (POF) based on clinical features. There are several variants of COF, including amyloid, ossifying, and giant cell. It grows slowly and exhibits painless cortical expansion of the jawbone. Radiographically, COF appears as a radiolucent unilocular or multilocular lesion with well-defined borders. COF may be associated with unerupted or displaced teeth and root resorption. Case Report: A 35-year-old man was referred to our hospital for submandibular swelling. Panoramic radiography and contrast-enhanced computed tomography revealed a unilocular area of bone resorption with a well-defined border and equal enhancement from the canine to first molar on the right side of the mandible. Root resorption of the first premolar and root separation of the first and second premolars were also evident. The lesion was asymptomatic. Histopathological examination of a biopsy of the lesion was suggestive of OF. Enucleation of the tumor, curettage of the bone around the tumor, and extraction of the premolar were then performed. Histopathological examination of the tumor showed fibrous connective tissue with inactive-looking odontogenic epithelial islands and strands, amyloid deposit, intercalation of Langerhans cells into the tumor epithelium, and no calcification. The final diagnosis of amyloid variant of COF was made. The postoperative course is going well. Conclusions: Herein we describe and discuss the clinical, radiological, and pathological features of the amyloid variant of COF. This report will enhance understanding of this extremely rare variant.

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“…This study followed the PRISMA Statement guidelines. 14 The methodology of this research has already been applied in other previous studies 12,13,15 and a new criterion of analysis has been used in the current study to analyze RISOC.…”

Section: Methodsmentioning

confidence: 99%

Oral radiation‐induced sarcomas: Systematic review

et al. 2020

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Background The aim of this study was to integrate the available data published on radiation‐induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. Methods An electronic search was undertaken in September 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Results Forty‐two publications with 122 radiation‐induced sarcoma of the oral cavities (RISOCs) were included. The mean latency period was 114 months and mean radiation total dose was 62.5 Gy. The tumors were more prevalent in males between 50 and 60 years old and the mandible was the most affected site. Osteosarcoma was the most prevalent histological type and patients were mostly treated with radical surgery. Conclusions RISOC showed a poor survival rate of 15.1% in 5‐year follow‐up. Gender and histological type were independently associated with survival.

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Central odontogenic fibroma: An updated systematic review of cases reported in the literature with emphasis on recurrence influencing factors

Cited by 24 publications

References 38 publications

Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma Like Lesion ; A Case Report and Review of the Literature

Hybrid Central Odontogenic Fibroma with Central Giant Cell Granuloma Like Lesion ; A Case Report and Review of the Literature

Amyloid Variant of Central Odontogenic Fibroma in the Mandible: A Case Report and Literature Review

Oral radiation‐induced sarcomas: Systematic review

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