Central neuroplasticity and lower limbs functional outcome following repetitive locomotor training in stroke patients

Shahine, Enas M.; Shafshak, Tarek S.

doi:10.4103/1110-161x.140520

Cited by 2 publications

(22 citation statements)

References 21 publications

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“…Sixteen studies have investigated the effect of gait-specific training on MEP amplitudes. Seven studies showed a significant increase in MEP amplitudes after gait training ( i.e ., robotic training [40,42–44], treadmill training [46], overground training [49] and FES combined to overground training [12]). Five of these studies [40,42–45] presented high methodological quality and two [46,49] were of moderate quality.…”

Section: Resultsmentioning

confidence: 99%

“…MT was reported in 7 studies. Four studies reported a decrease in MT after gait-specific training ( i.e ., overground gait training [55], BWSTT [35,41] and robotic gait training [44]), while 3 studies [50–52] did not report any significant changes after training. Three of the four studies showing a positive effect of gait-specific training on MT are RCT (PEDro <7), while those indicating a lack of change are pre/post studies (PEDro=3-4).…”

Section: Resultsmentioning

confidence: 99%

“…Three of the four studies showing a positive effect of gait-specific training on MT are RCT (PEDro <7), while those indicating a lack of change are pre/post studies (PEDro=3-4). In general, a significant decrease in MT has been observed after robotic training [44] or BWSTT [35,41,44]. Moreover, Yang et al [41] observed a decrease in the MT in subacute group but not in the chronic group after BWSTT.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the MEP increases after training have been observed in RF [42,44], TA [43,44,46], SOL [45], MG [44], HA [40] and extensor carpi radialis [46] muscles. However, it is important to mention that eight studies did not report significant change [34,47,48,50,51,53,55,56] and one study [54] showed a decrease in MEP amplitudes after gait-specific training.…”

Section: Effect Of Gait-specific Training On Corticospinal Excitabilitymentioning

confidence: 86%

“…Study design and quality assessment: Table 1 summarize the PEDro rating score for each of the 19 studies, which included 6 randomized controlled trials (RCT) [35,[40][41][42][43][44], 2 crossover studies [45,46], 1 cross-sectional study [34], 8 pre/post study [47][48][49][50][51][52][53] and 2 cases studies [54,55]. The methodological quality of the included studies ranged from 1 to 8 out of 10, with a median score of 4.…”

Section: Risk Of Biasmentioning

confidence: 99%

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Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review

Cherni

Tremblay

Simon

et al. 2022

Preprint

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Background: Corticospinal excitability is subject to alterations after stroke. While the reversal of these alterations has been proposed as an underlying mechanism for improvement walking capacity after gait-specific training, this has not yet been clearly demonstrated. Therefore, the objective of this review is to evaluate the effect of gait-specific training on corticospinal excitability in stroke survivors. Design: Systematic review of the literature Methods: We conducted an electronic database search in four databases (i.e., Medline, Embase, CINAHL and Web of Science) in June 2022. Two authors independently screened and selected all studies that investigated the effect of gait-specific training in post-stroke individuals on variables such as motor-evoked potential amplitude, motor threshold, map size, latency, and corticospinal silent period. Results: Nineteen studies investigating the effect of gait-specific training on corticospinal excitability were included. Some studies showed an increased MEP amplitude (7/16 studies), a decreased latency (5/7studies), a decreased motor threshold (4/8 studies), an increased map size (2/3 studies) and a decreased cortical silent period (1/2 study) after gait-specific training. No change has been reported in term of short interval intracortical inhibition after training. Five studies did not report any significant effect after gait-specific training on corticospinal excitability. Conclusion: The results of this systematic review suggest that gait-specific training modalities can drive neuroplastic adaptation among stroke survivors. However, given the methodological disparity of the included studies, further clinical trials with better methodological quality are needed to draw conclusions. Hence, the findings from this review can serve as a rationale for future studies and continued efforts in investigating the effects of gait-specific training on the central nervous system. Keywords: Locomotion, Task-oriented training, Corticospinal tract, Stroke, Neuroplasticity

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Effect Of Gait-specific Training On Corticospinal Excitabilitymentioning

confidence: 86%

Section: Risk Of Biasmentioning

confidence: 99%

See 3 more Smart Citations

Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review

Cherni

Tremblay

Simon

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review

Cherni

Tremblay

Simon

et al. 2022

IJERPH

View full text Add to dashboard Cite

Corticospinal excitability is subject to alterations after stroke. While the reversal of these alterations has been proposed as an underlying mechanism for improved walking capacity after gait-specific training, this has not yet been clearly demonstrated. Therefore, the objective of this review is to evaluate the effect of gait-specific training on corticospinal excitability in stroke survivors. We conducted an electronic database search in four databases (i.e., Medline, Embase, CINAHL and Web of Science) in June 2022. Two authors screened in an independent way all the studies and selected those that investigated the effect of gait-specific training on variables such as motor-evoked potential amplitude, motor threshold, map size, latency, and corticospinal silent period in stroke survivors. Nineteen studies investigating the effect of gait-specific training on corticospinal excitability were included. Some studies showed an increased MEP amplitude (7/16 studies), a decreased latency (5/7studies), a decreased motor threshold (4/8 studies), an increased map size (2/3 studies) and a decreased cortical silent period (1/2 study) after gait-specific training. No change has been reported in terms of short interval intracortical inhibition after training. Five studies did not report any significant effect after gait-specific training on corticospinal excitability. The results of this systematic review suggest that gait-specific training modalities can drive neuroplastic adaptation among stroke survivors. However, given the methodological disparity of the included studies, additional clinical trials of better methodological quality are needed to establish conclusions. The results of this review can therefore be used to develop future studies to better understand the effects of gait-specific training on the central nervous system.

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Central neuroplasticity and lower limbs functional outcome following repetitive locomotor training in stroke patients

Cited by 2 publications

References 21 publications

Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review

Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review

Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review

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