Central Neurocytoma: Rare Presentation in Fourth Ventricle and Review of Literature

Richardson, Angela M.; Armstrong, Valerie; Gernsback, Joanna E.; Gultekin, Sakir H.; Komotar, Ricardo J.

doi:10.1016/j.wneu.2018.12.021

Cited by 16 publications

(19 citation statements)

References 23 publications

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“…Typical location of CNs is the lateral ventricle touching the foramen of Munro 1table 1) have been reported to the best of our knowledge 2…”

Section: Descriptionmentioning

confidence: 79%

“…CNs were first described by Hassoun et al 3 in 1982. They are considered as low-grade tumours (WHO grade II), with an 89% 5-year survival 2. They are usually arising from the lateral ventricle, rarely the third ventricle.…”

Section: Descriptionmentioning

confidence: 99%

“…Reduction in proliferation rate following radiotherapy has been reported in some studies 5. For this reason, postoperative radiation can be considered in cases with incomplete resection of tumours or in tumours with higher proliferation rate 2…”

Section: Descriptionmentioning

confidence: 99%

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Central neurocytoma in the posterior fossa

et al. 2019

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“…Typical location of CNs is the lateral ventricle touching the foramen of Munro 1table 1) have been reported to the best of our knowledge 2…”

Section: Descriptionmentioning

confidence: 79%

Section: Descriptionmentioning

confidence: 99%

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Central neurocytoma in the posterior fossa

et al. 2019

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“…Extend of resection correlates with the rate of recurrence. Patients undergoing subtotal resection are commonly treated with adjuvant stereotactic radiation therapy, resulting in improved outcome compared to surgery alone (68). Extraventricular neurocytomas are also described and occur in the brain parenchyma, cerebellum or spinal cord (69).…”

Section: Central Neurocytomamentioning

confidence: 99%

Intraventricular neuroepithelial tumors: Surgical outcome, technical considerations and review of literature

Aftahy

Barz

Krauss

et al. 2020

Preprint

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Background Intraventricular neuroepithelial tumors (IVT) are rare lesions and comprise different pathological entities such as ependymomas, subependymomas and central neurocytomas. The treatment of choice is neurosurgical resection, which can be challenging due to their intraventricular location. Different surgical approaches to the ventricles are described. Here we describe a large series of IVTs, its postoperative outcome at a single tertiary center and discuss suitable surgical approaches. Methods We performed a retrospective chart review at a single tertiary neurosurgical center between 03/2009-05/2019. We included patients that underwent resection of an IVT emphasizing on surgical approach, extent of resection, clinical outcome and postoperative complications. Results 45 IVTs were resected from 03/2009 to 05/2019, 13 ependymomas, 21 subependymomas, 10 central neurocytomas and one glioependymal cyst. Median age was 52,5 years with 55.6% (22) male and 44.4% (20) female patients. Gross total resection was achieved in 93.3% (42/45). 84.6% (11/13) of ependymomas, 100% (12/21) of subependymomas, 90% (9/10) of central neurocytomas and one glioependymal cyst were completely removed. Postoperative rate of new neurological deficits was 26.6% (12/45). Postoperative new permanent cranial nerve deficits occurred in one case with 4th ventricle subependymoma and one in 4th ventricle ependymoma. Postoperative KPSS was 90% (IR 80–100). 31.1% of the patients improved in KPSS, 48.9% remained unchanged and 20% declined. Postoperative adverse events rate was 20.0%. Surgery-related mortality was 2.2%. The rate of shunt/cisternostomy-dependent hydrocephalus was 13.3% (6/45). 15.4% of resected ependymomas underwent adjuvant radiotherapy. Mean follow-up was 26,9 (± 30.1) months. Conclusion Our surgical findings emphasize satisfactory complete resection throughout all entities. Surgical treatment can remain feasible, if institutional experience is given. Satisfying long-term survival and cure is possible by complete removal. Gross total resection should always be performed under function-remaining aspects due to mostly benign or slow growing nature of IVTs. Further data is needed to evaluate standard of care and alternative therapy options in rare cases of tumor recurrence or in case of patient collective not suitable for operative resection.

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“…Uncommon cases have been reported in which central neurocytomas arise and remain confined within the third ventricle [2][3][4][5][6][7][8][9][10][11]. Of note, central neurocytomas may also arise in the fourth ventricle as well as in extraventricular sites including the pineal region, aqueduct of Sylvius, cerebral hemispheres, thalamus, pons, cerebellum, amygdala, retina, and cervical spinal cord [12][13][14][15][16][17][18][19][20][21]. Treatment typically involves gross total resection (GTR) when possible; recurrence is rare but, in some instances, may involve dissemination to other sites along the cerebrospinal fluid (CSF) transport system (e.g., reaching as far as the cervical and thoracic spine) [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Atypical Central Neurocytoma Confined to the Third Ventricle: Case Report and Systematic Review of the Literature

Chagoya

Bernstock

Elsayed

et al. 2019

SN Compr. Clin. Med.

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Central neurocytomas are relatively rare well-differentiated neoplasms that arise from neuronal cells with the atypical variant having been noted to be more uncommon/aggressive. Herein, we present a case of an atypical neurocytoma confined to the third ventricle and in so doing review surgical management and outcomes associated with such tumors. We identify a number of cases of central neurocytomas within the third ventricle and clarify both clinical presentation and disease course. Central neurocytomas within the third ventricle are rare while atypical neurocytomas confined to the third ventricle are exceedingly rare. Review of the literature suggests gross total resection should be the preferred treatment modality for these tumors, atypical or not. When only subtotal resection can be achieved, postoperative radiation might be helpful to control tumor recurrence rates. Keywords Atypical/central neurocytomas. Third ventricle. WHO grade II/III neoplasms. Ventricles. Gross total resection (GTR). Obstructive hydrocephalus This article is part of the Topical Collection on Surgery

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Central Neurocytoma: Rare Presentation in Fourth Ventricle and Review of Literature

Cited by 16 publications

References 23 publications

Central neurocytoma in the posterior fossa

Central neurocytoma in the posterior fossa

Intraventricular neuroepithelial tumors: Surgical outcome, technical considerations and review of literature

Atypical Central Neurocytoma Confined to the Third Ventricle: Case Report and Systematic Review of the Literature

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