Central Neurocytoma Presenting With Massive Hemorrhage Leading to Coma  -Case Report-

Terakawa, Yuzo; Tsuruno, Takashi; Ishibashi, Keiichiro; Okada, Yumiko; Shimotake, Katsumi; Murata, Takaho

doi:10.2176/nmc.50.139

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…Primary IVH is uncommon but can occur due to vascular malformation, intraventricular tumor (choroid plexus papilloma, central neurocytoma) or aneurysm of a distal striate artery. Hemorrhage in neurocytoma is regarded as rare (19 cases in the literature: 16 central neurocytoma; 3 extraventricular neurocytoma) (7). Terakawa et al estimated the rate of hemorrhage in neurocytoma as 3%. Peri‐operative hemorrhage was described in 1/19 cases in a retrospective review , and was associated with death.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Intraventricular Hemorrhage in Young Patients

Cryan¹,

Power

Brett³

2014

Brain Pathology

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Section: Discussionmentioning

confidence: 99%

Two Cases of Intraventricular Hemorrhage in Young Patients

Cryan¹,

Power

Brett³

2014

Brain Pathology

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“…3 Central neurocytoma is not commonly associated with intraventricular hemorrhage or acute clinical deterioration, yet multiple cases of CN with intratumoral hemorrhage have been reported. 11 Neuroimaging of CN typically demonstrates a large, discrete, solitary lobulated mass near the foramen of Monro, which is often attached to the septum pellucidum, expanding into 1 or both lateral ventricles or the third ventricle. 3,4 Repeated imaging typically shows slow growth.…”

Section: Commentmentioning

confidence: 99%

Atypical Central Neurocytoma With Sarcomatous Differentiation

Vemavarapu

Czyszczon²,

Parker³

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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We report a case of an intraventricular tumor with features of atypical central neurocytoma with a sarcomatous component in a 44-year-old woman who presented with headaches and vomiting. Magnetic resonance imaging revealed a 3.4-cm lobulated enhancing mass in the occipital horn of the left lateral ventricle, and the patient subsequently underwent a left occipital-parietal craniotomy for debulking. The tumor contained 2 cell populations: round cells with perinuclear halos in a fibrillary background, and spindle cells with oval nuclei arranged in interlacing fascicles with focal necrosis. The round cells had diffuse synaptophysin immunopositivity, while the spindle cells were diffusely immunopositive for vimentin and had intercellular reticulin. The mitotic activity (8 mitotic figures per 10 high-power fields) and the high Ki-67 proliferation index (15.0%) were consistent with atypical central neurocytoma with a sarcomatous component. Although different histologic variants have been described, this is the first reported case, to our knowledge, of central neurocytoma with spindle cell sarcomatous features.

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“…Generally, central neurocytoma affects young adults with the tumors most frequently localizing in the supratentorial ventricular system and demonstrating calcification on computed tomography (CT) images [3, 4] although various cases of extraventricular neurocytoma have also been reported [5–9]. Despite a substantial advancement in the diagnosis and management [10–12] since its initial description reported in 1982 [13], central neurocytoma is still often confused with other tumors of the central nervous system, especially oligodendrogliomas.…”

Section: Introductionmentioning

confidence: 99%

Differential Hypermethylation of Death-Associated Protein Kinase Promoter in Central Neurocytoma and Oligodendroglioma

Chung

Tsai

et al. 2014

BioMed Research International

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Background. Central neurocytoma and oligodendroglioma are rare tumors of the central nervous system. However, diagnosis between these two types of tumors is challenging due to their many cytological and histological similarities. Death-associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine protein kinase involved in many apoptosis pathways, and repressed expression of DAPK by promoter hypermethylation has been found in a variety of human cancers. The purpose of this study was to assess DAPK protein expression and promoter hypermethylation in central neurocytoma and oligodendroglioma. Method. Central neurocytoma and oligodendroglioma samples were obtained from age- and sex-matched patients. DAPK protein expression was performed using immunohistochemical assays in formalin-fixed, paraffin-embedded sections. DAPK promoter hypermethylation was carried out using bisulfite-modified genomic DNA in methylation-specific PCR followed by separation in agarose gels. Findings. A statistically significant difference (P = 0.021) in DAPK promoter hypermethylation between central neurocytoma (76.9%) and oligodendroglioma (20%) was observed. High levels of DAPK protein expression were generally found in oligodendroglioma (90%), compared with 38.5% in central neurocytoma (P = 0.054; not statistically significant). There was an inverse correlation between DAPK protein expression and DAPK promoter hypermethylation in the cohort of 23 patients (P = 0.002). Conclusions. The results show that DAPK promoter hypermethylation and repressed expression of DAPK protein were more common in central neurocytoma than in oligodendroglioma. Thus, DAPK promoter hypermethylation could be useful for differential diagnosis between these two types of tumors, whereas DAPK protein expression might be less predictive. The role of DAPK promoter hypermethylation in the pathogenesis of central neurocytoma warrants further study.

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Central Neurocytoma Presenting With Massive Hemorrhage Leading to Coma -Case Report-

Cited by 9 publications

References 29 publications

Two Cases of Intraventricular Hemorrhage in Young Patients

Two Cases of Intraventricular Hemorrhage in Young Patients

Atypical Central Neurocytoma With Sarcomatous Differentiation

Differential Hypermethylation of Death-Associated Protein Kinase Promoter in Central Neurocytoma and Oligodendroglioma

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