Central neurocytoma: clinical, pathological and neuroradiological findings

Zhang, D.; Li, Wen; Henning, TD; Feng, Xiaoyuan; Zhang, Y.-L.; Zou, Liping; Zhang, Z.-G.

doi:10.1016/j.crad.2006.01.002

Cited by 41 publications

(14 citation statements)

References 33 publications

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“…The tumor can also be heterogeneous because of the hypodense areas related to cystic degeneration [431]. In contrast-enhanced CT scans, CNs have mild to moderate enhancements [3262]. Furthermore, CNs appear slightly hypo-intense to iso-intense on T1-weighted magnetic reso-nance imaging (MRI) (Fig.…”

Section: Radiological Featuresmentioning

confidence: 99%

Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Lee

Bui

Chen

et al. 2016

Brain Tumor Res Treat

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Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be considered to improve tumor control when GTR cannot be achieved. Chemotherapy is also not considered a primary treatment, but has been used as a salvage therapy. The radiological features of CN are indistinguishable from those of other brain tumors; therefore, many histological markers, such as synaptophysin, can be very useful for diagnosing CNs. Furthermore, the MIB-1 Labeling Index seems to be correlated with the prognosis of CN. We also discuss oncogenes associated with these elusive tumors. Further studies may improve our ability to accurately diagnose CNs and to design the optimal treatment regimens for patients with CNs.

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Section: Radiological Featuresmentioning

confidence: 99%

Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Lee

Bui

Chen

et al. 2016

Brain Tumor Res Treat

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“…All the five cases presented with increased intracranial hypertension and secondary hydrocephalus as they were of large size and obstructing the CSF pathways. CT scans typically demonstrate an iso‐ or slightly hyperdense mass within the body of the lateral ventricles near the foramen of Monro as mentioned in literature 16–19. On MRI most cases showed a heterogeneous hypointensity on T1WI and hyperintensity on T2WI with a well‐defined margin.…”

Section: Discussionmentioning

confidence: 88%

“…Currently, no distinct diagnostic radiologic features have been identified for differentiating CN from oligodendroglioma, ependymoma, or intraventricular meningioma 16–19. Cells of CN should be distinguished under light microscope from small round cells of oligodendroglioma, ependymoma, subepndymal astrocytoma, and low grade non‐Hodgkin lymphoma 7, 9, 10.…”

Section: Discussionmentioning

confidence: 99%

Squash cytomorphology of central neurocytoma: A study of five cases

Jaiswal

Vij

Jaiswal

et al. 2010

Diagnostic Cytopathology

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Intraoperative consultation is an important component in the surgical management of brain tumors. This study was undertaken to describe the cytomorphological features of central neurocytoma (CN) in squash smears. Squash smear of five CNs were reviewed. One to two millimeters of the biopsy material was crushed between two glass slides to make a thin film that was fixed in 95% alcohol and stained with haematoxylin and eosin (H&E). Cytological diagnoses were correlated with clinical and radiological data and finally with histopathological findings in the tumor. We had 5 cases (4 males, 1 female; age, 19-61 years; mean, 32 years). All tumors were located in the lateral ventricle. The smears were highly cellular displaying monomoprhic round tumor cells, round to oval nuclei with evenly distributed finely granular chromatin and ill-defined cytoplasmic borders within fibrillar matrix. Focal rosette formation is also noted. A capillary network was identified in between tumor cells in all the cases. One case had calcification with numerous psamomma bodies identified in the squash smear. The differential diagnosis is discussed. On squash smears, CN can be diagnosed when cytomorphological features are correlated with clinical and radiological finding.

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“…Histologically they resemble oligodendrogliomas and were originally thought to be unusual intraventricular oligodendrogliomas until their neuronal character was established by electron microscopy. Currently, immunostaining for synaptophysin can confirm the neuronal nature (12, 13). Treatment is with complete surgical resection, but radiation can be used for recurrence or incomplete resection…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging of a Case of Central Neurocytoma

et al. 2016

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Background:The purpose of this study is to investigate the MRI features of central neurocytoma.Case report:A 45 year old man with 3 months of worsening daily headaches. These headaches were diffuse, lasted for several hours, and mostly occurred in the morning. She was initially diagnosed and treated for migraines but later he had epileptic attack and diplopia and neurolog recomaded MRI.Methods:precontrast MRI; TSE/T2Wsequence in axial/coronal planes; 3D–Hi-resolution T1W sagittal; FLAIR/T2W axial; FLAIR/T2W and Flash/T2W oblique coronal plane (perpendicular to temporal lobes) GRE/T2W axial plane for detection of heme products. Post-contrast TSE/T1W sequence in axial, coronal and sagittal planes. Diffusion weighted and ADC mapping MRI images for EPI sequence in axial plane.Results:A 23x12mm heterogeneous mass within aqueductus cerebri, with calcified and hemorrhagic foci and extending downwards till fourth ventricle. It’s originating from the right paramedian posterior aqueductal wall (tectum), and also extending to and involving the tegmentum of mesencephalon at its right paramedian aspect. CSF flow obstruction secondary to described aqueductal mass, with resultant triventricular hydrocephalus). Marked transependymal CSF leak can be noted at periventricular white matter, secondary to severe hydrocephalus. After IV injection of contrast media, this mass shows mild-to-moderate heterogenous speckled enhancement.Conclusion:MRI is helpful in defining tumor extension, which is important in preoperative planning. Although IN is a relatively rare lesion, it should be considered in the differential diagnosis of intraventricular lesions in the presence of such typical MR findings. However, a definitive diagnosis requires immunochemical study and electron microscopy.

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Central neurocytoma: clinical, pathological and neuroradiological findings

Cited by 41 publications

References 33 publications

Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Squash cytomorphology of central neurocytoma: A study of five cases

Magnetic Resonance Imaging of a Case of Central Neurocytoma

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