Central neurocytoma: Clinical, immunohistologic, and biologic findings of a human neuroglial progenitor tumor

Valdueza, J. M.; Westphal, Manfred; Vortmeyer, Alexander O.; Müller, Dieter; Padberg, Barbara; Herrmann, H. D.

doi:10.1016/0090-3019(95)00376-2

Cited by 59 publications

(43 citation statements)

References 29 publications

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“…Recent results of cell culture experiments support the hypothesis that the origin of central neurocytoma might be the subependymal plate of the lateral ventricles, a region of cytogenesis in the developing brain, possessing a persistent capacity to reenter into mitosis in response to injury (20,21,(23)(24)(25). Our observation of the angiographic findings of central neurocytoma also supports the proposition that central neurocytoma might originate from the lateral ventricle around the foramen of Monro rather than from the septum pellucidum.…”

Section: Discussionsupporting

confidence: 76%

Angiographic Characteristics of Central Neurocytoma Suggest the Origin of Tumor

Paek

Kim

et al. 2003

J Korean Med Sci

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The authors retrospectively analyzed the angiographic findings performed in 17 cases with central neurocytoma to document the angiographic characteristics and suggested the origin of tumor based on the angiographic findings. Their medical records and radiological investigations were reviewed and cerebral angiographies were thoroughly examined in arterial, capillary, and venous phases. In ten cases, marked or moderate tumor staining was found whereas the staining was either scanty or absent in seven cases. In the ten cases showing marked or moderate tumor staining, the feeding vessels were originated from the ipsilateral carotid and/or vertebro-basilar system. In the venous phase, the ipsilateral thalamostriate vein, tortuous and enlarged, was elevated, and the internal cerebral vein was depressed. Thus, the venous angle of the ipsilateral side was widened at an irregular contour. Based on the characteristic displacement and the increased size of the associated venous system, it is suggested that the central neurocytoma might originate from a neuronal cell mass of the subependymal zone located on the floor of the lateral ventricle around the foramen of Monro rather than from the septum pellucidum.

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Section: Discussionsupporting

confidence: 76%

Angiographic Characteristics of Central Neurocytoma Suggest the Origin of Tumor

Paek

Kim

et al. 2003

J Korean Med Sci

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“…Central neurocytoma first was described in 1982 by Hassoun et al as a midline neuronal tumor characterized by its intraventricular location, greater frequency among young adults, specific radiologic features, and good postoperative prognosis due to its benign clinical course [1,2,4,6,9,36,39,43]. Neurocytoma can arise from the septum pellucidum, fornix, or the walls of the lateral ventricles (subependymal layer).…”

Section: Discussion Historical Perspectives and Clinical Presentationmentioning

confidence: 99%

“…Neurocytoma can arise from the septum pellucidum, fornix, or the walls of the lateral ventricles (subependymal layer). It may derive from bipotential precursor cells of the periventricular germinal matrix, which are capable of both neuronal and glial differentiation, but maintain a low proliferative potential after birth [4,42,43,44]. Central neurocytoma has a long clinical course.…”

Section: Discussion Historical Perspectives and Clinical Presentationmentioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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Purpose-Central neurocytoma is a rare intraventricular brain tumor that affects young adults and presents with increased intracranial pressure secondary to obstructive hydrocephalus. Typically, it has a favorable prognosis after adequate surgical intervention, but in some cases the clinical course is more aggressive. In this report, we describe the diagnosis and treatment of central neurocytoma in a series of patients at our institution.Patients and Methods-Our series of nine patients (M:F=2:7, mean age, 28.2 years) with ventricular tumors showed typical radiological, histologic and immunohistochemical features of central neurocytoma. Most patients received craniotomy with removal of the tumor through transcallosal or transcortical approach. The surgical and histopathologic data of these patients were reviewed and analyzed.Results-The prognosis is generally favorable. Although most patients were alive and well at the last follow-up, two developed recurrence. Typical histologic features of recurrent neurocytoma include high proliferative activity (MIB-1 labeling index: 2.0-6.8%), prominent vascular proliferation and remarkable synaptophysin expression. Two patients (non-recurrent) died during follow-up due to sepsis or central failure. The MIB-1 labeling indices were as high as 2.2-5.4% for these two patients.Conclusion-Although central neurocytoma is generally a benign neoplasm, some variant forms of recurrence are also present. Complete resection provides favorable long-term prognosis in most cases. Recurrent tumors are often local and the patients seem to recover well after a second resection followed by radiotherapy. Histologic features such as tumor proliferation (MIB-1 labeling index), vascular proliferation, and synaptophysin expression are often prominent in the recurrent tumor. We recommend that these histologic features be considered for tumor recurrence during treatment and follow-up of these patients.

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“…CNs have been thought to be origi- nated from mature neuronal cells because of their ultrastructural neuron-specific features, such as microtubules, neurofilaments, and synaptic junctions. However, there is little known about tumor origin [14]. SEs are known to be from the ependymal nests in the germinal matrix, and classified as grade 1 tumor in WHO classification [1].…”

Section: Characteristics Of Tumors Located Around Foramen Of Monromentioning

confidence: 99%

Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma

You

Kim

et al. 2005

J Neurooncol

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Central neurocytoma: Clinical, immunohistologic, and biologic findings of a human neuroglial progenitor tumor

Cited by 59 publications

References 29 publications

Angiographic Characteristics of Central Neurocytoma Suggest the Origin of Tumor

Angiographic Characteristics of Central Neurocytoma Suggest the Origin of Tumor

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma

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