Central Nervous System Sarcoidosis: Follow-up at MR Imaging during Steroid Therapy

Abstract

MR imaging can be used to differentiate between reversible and irreversible lesions in CNS sarcoidosis. MR imaging can be a useful tool for adjusting treatment to prevent irreversible CNS damage.

Correlation of MR Imaging Findings and Clinical Manifestations in Neurosarcoidosis

“…Sarcoid myelopathy may mimic multiple sclerosis, tumor, vacuolar myelopathy, tuberculosis, and fungal infections. 14,20,23 Similar to findings in previous reports, 13,14 we did not find any correlation between nonenhancing white matter lesions with clinical symptoms. These lesions also did not demonstrate any response to therapy and may also be seen in patients who do not have sarcoidosis.…”

“…8,13,14 In this study, we analyzed clinical and radiologic records of patients with biopsyproved or clinically diagnosed neurosarcoidosis for the following reasons: 1) to assess the concordance between abnormalities noted on MR imaging with neurologic symptoms at presentation; 2) to correlate changes in imaging findings during follow-up with clinical improvement or worsening; and 3) to identify imaging features that may have prognostic significance.…”

A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin-converting enzyme

“…Corticosteroids are the therapy of choice as they have been reported to improve neurological symptoms and reduce intracranial sarcoid spread confirmed by MRI [16,17,18]. In our case, corticosteroids therapy was effective and revealed an obvious decrease of the lesion size.…”

Diabetes Insipidus from Neurosarcoidosis: Long-term Follow-up for More than Eight Years

“…MRI is an important tool in monitoring the course of neurosarcoidosis and its response to therapy (13). By means of MRI, it is confirmed that corticosteroid generally improves the neurological symptoms and causes reduction in intracranial sarcoid spread.…”