Central Nervous System Reactions Associated With Famotidine

Odeh, Majed; Oliven, Arie

doi:10.1097/00004836-199810000-00014

Cited by 16 publications

(8 citation statements)

References 14 publications

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“…Failure to reduce doses of famotidine in patients with severe renal impairment is known to be associated with mental status changes including confusion, agitation, delirium, irritability, and hallucinations. 27,28 Our results are consistent with several retrospective studies in more than 20,000 patients with CKD reporting that use of the MDRD equation overestimates Cl cr , leading to significantly higher drug doses compared with doses calculated by using CG. [29][30][31][32] Our median discordance of 28% for the MDRD equation is consistent with data reported in one study.…”

Section: Discussionsupporting

confidence: 89%

“…For example, use of the MDRD equation resulted in a 41% discordance rate for famotidine, in which all discordant cases would have resulted in higher doses being given to patients if the MDRD equation was used instead of the CG equation. Failure to reduce doses of famotidine in patients with severe renal impairment is known to be associated with mental status changes including confusion, agitation, delirium, irritability, and hallucinations …”

Section: Discussionmentioning

confidence: 99%

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Glomerular Filtration Rate Equations Overestimate Creatinine Clearance in Older Individuals Enrolled in the Baltimore Longitudinal Study on Aging: Impact on Renal Drug Dosing

et al. 2013

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Objectives To evaluate performance of kidney function estimation equations and to determine the frequency of drug dose discordance in an older population. Design Cross-sectional analysis of data from community-dwelling volunteers randomly selected from the Baltimore Longitudinal Study of Aging from January 1, 2005–December 31, 2010. Subjects Two hundred sixty-nine men and women with a mean ± SD age of 81 ± 6 years, mean serum creatinine concentration (Scr) of 1.1 ± 0.4 mg/dl, and mean measured 24-hour creatinine clearance (mClcr) of 53 ± 13 ml/minute. Measurements and Main Results Kidney function was estimated by using the following equations: Cockcroft-Gault (CG), Modification of Diet in Renal Disease Study (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). The performance of each equation was assessed by measuring bias and precision relative to mClcr. Dose calculation errors (discordance) were determined for 10 drugs requiring renal dosage adjustments to avoid toxicity when compared to the FDA-approved dosages. The CG equation was the least biased estimate of mClcr. The MDRD and CKD-EPI equations were significantly positively biased compared to CG (mean ± SD 34 ± 20% and 22 ± 15%, respectively, p<0.001) and mClcr (29 ± 47% and 18 ± 40%, respectively, p<0.001). Rounding low Scr values (< 1.0 mg/dl) up to an arbitrary value of 1.0 mg/dL resulted in CG values (44±10 mL/min) that were significantly lower than mClcr (56±12 mL/min, p<0.001) and CG (56±15 mL/min, p<0.001). The MDRD and CKD-EPI equations had median dose discordance rates of 28.6% and 22.9%, respectively. Conclusion The MDRD and CKD-EPI equations significantly overestimated creatinine clearance (mClcr and CG) in elderly individuals. This leads to dose calculation errors for many drugs, particularly in individuals with severe renal impairment. Thus, GFR-estimating equations should not be substituted in place of the CG equation in older adults for the purpose of renal dosage adjustments. In addition, the common practice of rounding or replacing low Scr values with an arbitrary value of 1.0 mg/dL for use in the CG equation should be avoided. Additional studies that evaluate alternative eGFR equations in the older populations that incorporate pharmacokinetic and pharmacodynamic outcomes measures are needed.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate Equations Overestimate Creatinine Clearance in Older Individuals Enrolled in the Baltimore Longitudinal Study on Aging: Impact on Renal Drug Dosing

et al. 2013

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“…The Odeh's work [11] also evidenced the role of age and underlying renal failure in the occurrence of central ADRs (but not mania) with famotidine. They can also suggest some predisposing factors for manic episodes associated with H2 receptor antagonists: age (most of cases occurred in old patients), decrease in renal and/ or hepatic function, or polymedication, sometimes but not always.…”

Section: Discussionmentioning

confidence: 98%

Mania associated with ranitidine: a case report and review of literature

Mauran

Gozé

Abadie

et al. 2016

Fundamemntal Clinical Pharma

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H2 receptor antagonists can be associated with central adverse drug reactions (ADRs), like confusion, delirium, hallucinations, slurred speech or headaches. We report here a 'serious' case of severe mania leading to hospitalization in a 42-year-old alcohol-dependent man, 4 days after ranitidine introduction. Review of literature showed that this 'very rare' ADR occurs mainly in patients with predisposing factors: age, decrease in renal and/or hepatic function, polymedication, alcohol. Knowledge of this ADR can be particularly important for these drugs widely used as self-medication.

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“…Many medications are widely prescribed for these indications in both the general population and in patients with kidney disease. Care should be taken with use of these agents in patients with ESRD because of inherent characteristics of the drugs and dialysis 5–10 . Despite the high prevalence of indications for GI medications in the dialysis population, relatively little is known about proton pump inhibitor (PPI) and H 2 receptor antagonist (HA) prescription patterns, apart from frequency of use.…”

Section: Introductionmentioning

confidence: 99%

“…Care should be taken with use of these agents in patients with ESRD because of inherent characteristics of the drugs and dialysis. [5][6][7][8][9][10] Despite the high prevalence of indications for GI medications in the dialysis population, relatively little is known about proton pump inhibitor (PPI) and H 2 receptor antagonist (HA) prescription patterns, apart from frequency of use. The 1998 annual report from the United States Renal Data System (USRDS), which described data collected in 1996, showed that 30% of patients sampled were prescribed either agent, but did not specify the exact proportions of the agents used.…”

Section: Introductionmentioning

confidence: 99%

Large variations in prescriptions of gastrointestinal medications in hemodialysis patients on three continents: The Dialysis Outcomes and Practice Patterns Study (DOPPS)

Bailie

Mason

Elder

et al. 2006

Hemodialysis International

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Little is known about proton pump inhibitor (PPI) or H(2) receptor antagonist (HA) prescription patterns or regarding use of predictors in hemodialysis patients. Proton pump inhibitor and HA prescribing patterns were investigated in 8628 hemodialysis patients from seven countries enrolled in the prospective, observational Dialysis Outcomes and Practice Patterns Study. Logistic regression examined predictors associated with PPI and HA use, adjusting for age, sex, country, time with end-stage renal disease, medications, 14 comorbid conditions, and the association between the number of comorbid conditions and the prescription of gastrointestinal (GI) medications. In a cross-section from February 1, 2000, 3.4% to 36.9% of patients received an HA and 0.8% to 26.9% took a PPI, depending upon the country. From 1996 to 2001, the prescription of HAs declined while PPI use increased. Facility use of HAs and PPIs ranged from 0% to 94% of patients. H2 receptor antagonist or PPI use was significantly and independently associated with age, narcotic use, corticosteroids, acetaminophen, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, selective serotonin reuptake inhibitors, coronary artery disease history, cardiovascular diseases other than hypertension or congestive heart failure, peripheral vascular disease, pulmonary disease, and GI bleed. Proton pump inhibitors or HAs were more likely to be prescribed in Italy, Spain, and the United Kingdom than in the United States. The odds of PPI prescription increased if serum phosphorus <5.5 mEq/L or serum albumin <3.5 g/dL. Prescription of GI medications was associated with many comorbidities and use of several medications. Extreme variability of prescription patterns suggests that there is no standard approach in treatment practices.

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Central Nervous System Reactions Associated With Famotidine

Cited by 16 publications

References 14 publications

Glomerular Filtration Rate Equations Overestimate Creatinine Clearance in Older Individuals Enrolled in the Baltimore Longitudinal Study on Aging: Impact on Renal Drug Dosing

Glomerular Filtration Rate Equations Overestimate Creatinine Clearance in Older Individuals Enrolled in the Baltimore Longitudinal Study on Aging: Impact on Renal Drug Dosing

Mania associated with ranitidine: a case report and review of literature

Large variations in prescriptions of gastrointestinal medications in hemodialysis patients on three continents: The Dialysis Outcomes and Practice Patterns Study (DOPPS)

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