Central nervous system myelomatosis: review of the literature

Nieuwenhuizen, Laurens; Biesma, Douwe H.

doi:10.1111/j.1600-0609.2007.00956.x

Cited by 106 publications

(209 citation statements)

References 73 publications

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“…In the majority of patients this complication appears as a terminal event, but it can also develop in patients with a complete systemic remission [2] which was the case of our patient.…”

Section: Discussionsupporting

confidence: 68%

“…In sharp contrast to other hematologic malignancies, direct involvement with accumulation of plasma cells in the CNS is extremely rare in multiple myeloma patients and can only be observed in approximately 1% of cases [2]. This extramedullary presentation and⁄or complication of multiple myeloma is generally a result from bone lesions in the cranial vault [3].…”

Section: Discussionmentioning

confidence: 99%

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Intracranial Epidural Plasmacytoma Presenting as a Neurosurgical Emergency: Case Report

Nsir¹,

Darmoul²,

Hadhri³

et al. 2013

OJMN

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Intracranial plasmacytomas are infrequently encountered in neurosurgical practice, and the literature consists predominantly of isolated case reports. We present the first English medical literature case of intracranial epidural plasmacytoma with no calvarial lytic changes masquerading as an extradural hematoma in a 60 year-old-man. In addition, we discuss the pathogenesis of this unusual tumor location with brief review of the relevant literature concerning its treatment and outcome.

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“…In the majority of patients this complication appears as a terminal event, but it can also develop in patients with a complete systemic remission [2] which was the case of our patient.…”

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Intracranial Epidural Plasmacytoma Presenting as a Neurosurgical Emergency: Case Report

Nsir¹,

Darmoul²,

Hadhri³

et al. 2013

OJMN

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“…This presentation of MM can occur as primary parenchymal brain lesion, osteodural or leptomeningeal involvement. The latter CNS localization of MM, also termed myelomatous meningitis or central nervous system myelomatosis (CNS-MM) is very uncommon, accounting for about 1% of patients [3][4][5] and is characterized by the presence of neoplastic plasma cells in the cerebrospinal fluid (CSF). 5,6 The pathogenesis of such a phenomenon might be due to the haematogenous spread of plasma cells or of their circulating progenitors.…”

Section: Introductionmentioning

confidence: 99%

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Marini

Carulli

Lari

et al. 2014

J Clin Exp Hematopathol

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Central nervous system (CNS) involvement in multiple myeloma (MM) is uncommon. Among its possible presentations, leptomeningeal involvement of MM, also termed central nervous system myelomatosis (CNS-MM) is rare and is characterized by the presence of neoplastic plasma cells in the cerebrospinal fluid (CSF). So far, 187 cases of CNS-MM have been reported : the great majority of them were diagnosed by cytological assays and flow cytometry was used in only eight cases. We describe a case of CNS-MM in a 62-year-old woman, previously treated with chemotherapy (VTD) and autologous peripheral blood hematopoietic stem cell transplantation for stage IIIB IgG-l MM. After achieving a very good partial response, the patient showed progression of disease, with an extramedullary localization. During administration of second-line therapy, the patient showed severe neurological symptoms. MRI resulted negative. Diagnosis of CNS-MM was made by multiparameter flow cytometry, which showed the presence of CD56 + plasma cells in a CSF sample, in the absence of plasma cell leukemia. In this paper we also present a review of the eight previous cases of CNS-MM diagnosed by flow cytometry. We found that the application of flow cytometry in cases of MM with neurological symptoms allows a rapid diagnosis of CNS-MM and provides useful information about plasma cell phenotype (including CD56 expression). Some cases of CNS-MM are characterized by normal MRI. In addition, some evidences deriving from the review of literature suggest that CSF monitoring by flow cytometry in such cases might be used to evaluate the efficacy of drugs capable of crossing the blood-brain barrier. 〔J Clin Exp Hematop 54 (2) : 129-136, 2014〕

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“…There are two reviews summarizing the profile of multiple myeloma cases with CNS involvement [1,3]. In the study of Nieuwenhuizen et al a better outcome with kappa CNS multiple myeloma when compared with the group with lambda CNS multiple myeloma had been suggested (P = 0.22).…”

Section: Discussionmentioning

confidence: 99%

Intracranial plasmacytoma as an initial presentation of multiple myeloma

et al. 2010

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AbstractIntra-cranial involvement is an uncommon complication of multiple myeloma. We report a 68-year-old woman hospitalized for acute renal failure, vertigo and headache. Magnetic Resonance Imaging (MRI) revealed two and a half and 3cm length cranial lesion, which proved to be plasmacytoma. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with intracranial involvement. Cytogenetic analysis of plasma cells detected no change. Currently, she is a regular hemodialysis patient. She is planned to have both systemic therapy with 40mg dexamethasone and cranial radiotherapy. Involvement of the CNS in multiple myeloma is very rare. Diagnosis of multiple myeloma subsequent to initial intrcranial involvement is confined to exceptional cases. Despite aggressive systemic treatments, including autologous stem cell transplantation and local treatments such as cerebral radiotherapy, the prognosis for patients with CNS myeloma is extremely poor. Our unique case implies that physicians should be alert in case of vertigo or headache in cases with acute renal failure.

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Central nervous system myelomatosis: review of the literature

Cited by 106 publications

References 73 publications

Intracranial Epidural Plasmacytoma Presenting as a Neurosurgical Emergency: Case Report

Intracranial Epidural Plasmacytoma Presenting as a Neurosurgical Emergency: Case Report

Myelomatous Meningitis Evaluated by Multiparameter Flow Cytometry : Report of a Case and Review of the Literature

Intracranial plasmacytoma as an initial presentation of multiple myeloma

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