2007
DOI: 10.1111/j.1600-0609.2007.00956.x
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Central nervous system myelomatosis: review of the literature

Abstract: Involvement of the central nervous system (CNS) in multiple myeloma (MM) is very uncommon; it has been observed in approximately 1% of the MM patients. This review summarizes the clinical and laboratory characteristics and treatment modalities of 109 patients with CNS myelomatosis (CNS MM) reported in the literature. CNS MM has a wide spectrum of neurological symptoms and signs. No guidelines for therapy of CNS MM are available, which has resulted in a large variation in the treatment schedules. Treatment opti… Show more

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Cited by 106 publications
(208 citation statements)
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References 73 publications
(101 reference statements)
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“…In the majority of patients this complication appears as a terminal event, but it can also develop in patients with a complete systemic remission [2] which was the case of our patient.…”
Section: Discussionsupporting
confidence: 68%
See 1 more Smart Citation
“…In the majority of patients this complication appears as a terminal event, but it can also develop in patients with a complete systemic remission [2] which was the case of our patient.…”
Section: Discussionsupporting
confidence: 68%
“…In sharp contrast to other hematologic malignancies, direct involvement with accumulation of plasma cells in the CNS is extremely rare in multiple myeloma patients and can only be observed in approximately 1% of cases [2]. This extramedullary presentation and⁄or complication of multiple myeloma is generally a result from bone lesions in the cranial vault [3].…”
Section: Discussionmentioning
confidence: 99%
“…This presentation of MM can occur as primary parenchymal brain lesion, osteodural or leptomeningeal involvement. The latter CNS localization of MM, also termed myelomatous meningitis or central nervous system myelomatosis (CNS-MM) is very uncommon, accounting for about 1% of patients [3][4][5] and is characterized by the presence of neoplastic plasma cells in the cerebrospinal fluid (CSF). 5,6 The pathogenesis of such a phenomenon might be due to the haematogenous spread of plasma cells or of their circulating progenitors.…”
Section: Introductionmentioning
confidence: 99%
“…There are two reviews summarizing the profile of multiple myeloma cases with CNS involvement [1,3]. In the study of Nieuwenhuizen et al a better outcome with kappa CNS multiple myeloma when compared with the group with lambda CNS multiple myeloma had been suggested (P = 0.22).…”
Section: Discussionmentioning
confidence: 99%