Central Nervous System Monoamine Correlates of Social Dominance in Cynomolgus Monkeys (Macaca fascicularis)

Kaplan, Jay R.; Manuck, Stephen B.; Fontenot, M. Babette; Mann, J. John

doi:10.1016/s0893-133x(01)00344-x

Cited by 98 publications

(79 citation statements)

References 58 publications

(90 reference statements)

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“…There is unequivocal evidence that social status exerts a profound impact on nonhuman primate physiology (e.g., Grant et al, 1998;Kaplan and Manuck, 1999;Kaplan et al, 2002) and can influence the behavioral effects of dopaminergic drugs. For example, effects of d-amphetamine on aggression are more profound in dominant than subordinate squirrel monkeys (Miczek and Gold, 1983;Martin et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Relative Reinforcing Strength of Cocaine in Socially Housed Monkeys Using a Choice Procedure

Czoty

McCabe²,

Nader³

2004

J Pharmacol Exp Ther

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Position in the social hierarchy can influence brain dopamine function and cocaine reinforcement in nonhuman primates during early cocaine exposure. With prolonged exposure, however, initial differences in rates of cocaine self-administration between dominant and subordinate monkeys dissipate. The present studies used a choice procedure to assess the relative reinforcing strength of cocaine in group-housed male cynomolgus monkeys with extensive cocaine self-administration histories. Responding was maintained under a concurrent fixed-ratio 50 schedule of food and cocaine (0.003-0.1 mg/kg per injection) presentation. Responding on the cocaine-associated lever increased as a function of cocaine dose in all monkeys. Although response distribution was similar across social rank when saline or relatively low or high cocaine doses were the alternative to food, planned t tests indicated that cocaine choice was significantly greater in subordinate monkeys when choice was between an intermediate dose (0.01 mg/kg) and food. When a between-session progressive-ratio procedure was used to increase response requirements for the preferred reinforcer (either cocaine or food), choice of that reinforcer decreased in all monkeys. The average response requirement that produced a shift in response allocation from the cocaineassociated lever to the food-associated lever was higher in subordinates across cocaine doses, an effect that trended toward significance (p ϭ 0.053). These data indicate that despite an extensive history of cocaine self-administration, most subordinate monkeys were more sensitive to the relative reinforcing strength of cocaine than dominant monkeys.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Relative Reinforcing Strength of Cocaine in Socially Housed Monkeys Using a Choice Procedure

Czoty

McCabe²,

Nader³

2004

J Pharmacol Exp Ther

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“…However, animal studies have found that the creation of hierarchies affects activity in dopaminergic pathways of the brain associated with motivation (e.g., Kaplan et al 2002, Morgan et al 2002. For instance, Morgan et al (2002) first housed monkeys individually and found that they had similar dopamine levels.…”

Section: Power As Activating Wanting and Goal Seeking: Empirical Evmentioning

confidence: 99%

How Power Affects People: Activating, Wanting, and Goal Seeking

Guinote

2017

Annu. Rev. Psychol.

278

274

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Sociocognitive research has demonstrated that power affects how people feel, think, and act. In this article, I review literature from social psychology, neuroscience, management, and animal research and propose an integrated framework of power as an intensifier of goal-related approach motivation. A growing literature shows that power energizes thought, speech, and action and orients individuals toward salient goals linked to power roles, predispositions, tasks, and opportunities. Power magnifies self-expression linked to active parts of the self (the active self ), enhancing confidence, self-regulation, and prioritization of efforts toward advancing focal goals. The effects of power on cognitive processes, goal preferences, performance, and corruption are discussed, and its potentially detrimental effects on social attention, perspective taking, and objectification of subordinates are examined. Several inconsistencies in the literature are explained by viewing power holders as more flexible and dynamic than is usually assumed.

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“…Thus, while there are few changes in brain serotonergic activity following a second interaction with a familiar opponent, those that occur do not appear to be increases stimulated by a second stressful social interaction, but rather are represented by reductions in serotonergic activity, modulated by visual sign stimuli (raphé) and previous social status (hippocampal CA 3 ) respectively [39]. Dopaminergic activity is also influenced by social status and social interactions [3,17,32,51,84]. Dopaminergic activity in hippocampal nuclei of various vertebrate species has also been shown to be critical for spatial memory formation and retrieval [61,81].…”

Section: Central Monoaminergic Response To a Second Social Interactionmentioning

confidence: 99%

Memory of opponents is more potent than visual sign stimuli after social hierarchy has been established

Korzan

Höglund²,

Watt

et al. 2007

Behavioural Brain Research

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During agonistic interactions between male Anolis carolinensis, perception of a visual sign stimulus (darkened eyespots) not only inhibits aggression and promotes initial attainment of dominant social status, but also evokes distinct neuroendocrine responses in each opponent. This study was designed to examine the effect of eyespot manipulation on behavior and social rank during a second interaction between opponents that had previously established a natural dyadic social hierarchy. Prior to a second interaction, eyespots of familiar size-matched combatants were manipulated to reverse information conveyed by this visual signal. Eyespots on the previously dominant male were masked with green paint to indicate low aggression and social status. Previously subordinate males had their eyespots permanently marked with black paint to convey high aggression and status. Opponents were then repaired for a second 10 min interaction following either one or three days of separation. Aggression was generally decreased and social status between pairs remained reasonably consistent. Unlike rapidly activated monoaminergic activity that occurs following the initial pairing, most brain areas sampled were not affected when animals were re-introduced, regardless of visual signal reversal or length of separation between interactions. However in males with "normal" eyespot color, dominant males had reduced serotonergic activity in CA 3 and raphé, while subordinate males exhibited elevated CA 3 dopaminergic activity. Reversing eyespot color also reversed serotonergic activity in raphé and dopaminergic activity in CA 3 after three days of separation. The results suggest that males remember previous opponents, and respond appropriately to their previous social rank in spite of eyespot color.

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Central Nervous System Monoamine Correlates of Social Dominance in Cynomolgus Monkeys (Macaca fascicularis)

Cited by 98 publications

References 58 publications

Assessment of the Relative Reinforcing Strength of Cocaine in Socially Housed Monkeys Using a Choice Procedure

Assessment of the Relative Reinforcing Strength of Cocaine in Socially Housed Monkeys Using a Choice Procedure

How Power Affects People: Activating, Wanting, and Goal Seeking

Memory of opponents is more potent than visual sign stimuli after social hierarchy has been established

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