Central nervous system microstimulation: Towards selective micro-neuromodulation

Urdaneta, Morgan E.; Koivuniemi, Andrew S.; Otto, Kevin J.

doi:10.1016/j.cobme.2017.09.012

Cited by 14 publications

(9 citation statements)

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“…Microelectrode recordings of single-units have revealed fundamental basic neurophysiology of subcortical structures, but continued LFP characterization of non-motor processing remains critical for clinical translation. For instance, macroelectrodes implanted in the basal ganglia for movement and neuropsychiatric disorders reliably record LFPs—not single-units—and their electrophysiological capabilities are more resistant to the foreign body response (Vetter et al, 2004 ; Koivuniemi et al, 2011 ; Urdaneta et al, 2017 ; Wong et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Beyond basic neuroscience investigation, this line of work has important clinical implications for a wide range of neurological and psychiatric disorders. For instance, it may elucidate the observed improvements or deteriorations in non-motor symptoms seen after DBS for a broad range of FDA-approved and experimental uses (Parsons et al, 2006 ), and offer insights for more selective neuromodulation therapies (Urdaneta et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology

et al. 2018

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Although the basal ganglia have been implicated in a growing list of human behaviors, they include some of the least understood nuclei in the brain. For several decades studies have employed numerous methodologies to uncover evidence pointing to the basal ganglia as a hub of both motor and non-motor function. Recently, new electrophysiological characterization of the basal ganglia in humans has become possible through direct access to these deep structures as part of routine neurosurgery. Electrophysiological approaches for identifying non-motor function have the potential to unlock a deeper understanding of pathways that may inform clinical interventions and particularly neuromodulation. Various electrophysiological modalities can also be combined to reveal functional connections between the basal ganglia and traditional structures throughout the neocortex that have been linked to non-motor behavior. Several reviews have previously summarized evidence for non-motor function in the basal ganglia stemming from behavioral, clinical, computational, imaging, and non-primate animal studies; in this review, instead we turn to electrophysiological studies of non-human primates and humans. We begin by introducing common electrophysiological methodologies for basal ganglia investigation, and then we discuss studies across numerous non-motor domains–emotion, response inhibition, conflict, decision-making, error-detection and surprise, reward processing, language, and time processing. We discuss the limitations of current approaches and highlight the current state of the information.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology

et al. 2018

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“…Clinical work has shown that ICMS of somatosensory cortex (S1) can elicit touch percepts in patients with paralysis ( Flesher et al, 2016 ). The use of implantable microelectrodes allows for the spatial selectivity ( Urdaneta et al, 2017 ) necessary to elicit naturalistic touch percepts in specific areas of the arm ( Salas et al, 2018 ) or individual fingers ( Flesher et al, 2016 ). While this is encouraging, the widespread implementation of ICMS technologies for chronic use requires further understanding of the challenges inherently associated with implantable microelectrodes, such as the foreign body response (FBR) ( Biran et al, 2005 ) and the long-term stability of ICMS.…”

Section: Introductionmentioning

confidence: 99%

The Long-Term Stability of Intracortical Microstimulation and the Foreign Body Response Are Layer Dependent

et al. 2022

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Intracortical microstimulation (ICMS) of the somatosensory cortex (S1) can restore sensory function in patients with paralysis. Studies assessing the stability of ICMS have reported heterogeneous responses across electrodes and over time, potentially hindering the implementation and translatability of these technologies. The foreign body response (FBR) and the encapsulating glial scar have been associated with a decay in chronic performance of implanted electrodes. Moreover, the morphology, intrinsic properties, and function of cells vary across cortical layers, each potentially affecting the sensitivity to ICMS as well as the degree of the FBR across cortical depth. However, layer-by-layer comparisons of the long-term stability of ICMS as well as the extent of the astrocytic glial scar change across cortical layers have not been well explored. Here, we implanted silicon microelectrodes with electrode sites spanning all the layers of S1 in rats. Using a behavioral paradigm, we obtained ICMS detection thresholds from all cortical layers for up to 40 weeks. Our results showed that the sensitivity and long-term performance of ICMS is indeed layer dependent. Overall, detection thresholds decreased during the first 7 weeks post-implantation (WPI). This was followed by a period in which thresholds remained stable or increased depending on the interfacing layer: thresholds in L1 and L6 exhibited the most consistent increases over time, while those in L4 and L5 remained the most stable. Furthermore, histological investigation of the tissue surrounding the electrode showed a biological response of microglia and macrophages which peaked at L1, while the area of the astrocytic glial scar peaked at L2/3. Interestingly, the biological response of these FBR markers is less exacerbated at L4 and L5, suggesting a potential link between the FBR and the long-term stability of ICMS. These findings suggest that interfacing depth can play an important role in the design of chronically stable implantable microelectrodes.

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“…In order to monitor and control the brain activity, control units that are able to translate the natural signals from brain into understandable machine commands (i.e., Brain-Machine Interfaces -BMIs) has been developed in the past years [47]. BMIs are conceived as a new treatment method or therapy for neural diseases, and cognitive abilities problems [48]. For instance, patients with the loss of somatosensation, (i.e., tactile sensation) suffer from the serious deficits in motor control or struggle to manipulate objects using prosthesis, can be treated with neurostimulation using BMIs.…”

Section: Nervous and Neural Interfacesmentioning

confidence: 99%

A Review on Bio-Cyber Interfaces for Intrabody Molecular Communications Systems

Koucheryavy,

Yastrebova,

Martins

et al. 2021

Preprint

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The recent advancements in bio-engineering and wireless communications systems have motivated researchers to propose novel applications for telemedicine, therapeutics and human health monitoring. For instance, through wireless medical telemetry a healthcare worker can remotely measure biological signals and control certain processes in the organism required for the maintenance of the patient's health state. This technology can be further extended to use Bio-Nano devices to promote a real-time monitoring of the human health and storage of the gathered data in the cloud. This brings new challenges and opportunities for the development of biosensing network, which will depend on the extension of the current intrabody devices functionalities. In this paper we will cover the recent progress made on implantable micro-scale devices and introduce the perspective of improve them to foster the development of new theranostics based on data collected at the nanoscale level.

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Central nervous system microstimulation: Towards selective micro-neuromodulation

Cited by 14 publications

References 189 publications

Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology

Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology

The Long-Term Stability of Intracortical Microstimulation and the Foreign Body Response Are Layer Dependent

A Review on Bio-Cyber Interfaces for Intrabody Molecular Communications Systems

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