1978
DOI: 10.1016/0002-9343(78)90748-9
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Central nervous system manifestations of hyperparathyroidism

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Cited by 163 publications
(62 citation statements)
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“…(37) reported that small amounts of PTH stimulated mitotic activity and RNA and heme synthesis by erythroid precursors, while large amounts of the hormone inhibited these processes. Finally, it should be mentioned that the prolonged exposure of other tissues such as the brain or the peripheral nerves to excess PTH significantly increased their calcium content and was associated with disturbances in their function (55)(56)(57)(58)(59)(60).…”
Section: Discussionmentioning
confidence: 99%
“…(37) reported that small amounts of PTH stimulated mitotic activity and RNA and heme synthesis by erythroid precursors, while large amounts of the hormone inhibited these processes. Finally, it should be mentioned that the prolonged exposure of other tissues such as the brain or the peripheral nerves to excess PTH significantly increased their calcium content and was associated with disturbances in their function (55)(56)(57)(58)(59)(60).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, increased levels of aluminum in the brain may be related to some forms of uremic encephalopathy (9). However, removal of certain potential "uremic neurotoxins," such as aluminum or PTH, does not reverse uremic encephalopathy, although parathyroidectomy in uremic subjects does result in improvement both in physiologic testing and the electroencephalogram (10). Thus, other biochemical alterations are most likely present.…”
mentioning
confidence: 99%
“…Although the precise mechanism which caused par kinsonism in our patient is somewhat unclear, hyper calcemia or a parathormone neurotoxicity independent calcium toxic effect (16,17) may have contributed to the symptoms. It seems likely that there may be some kind of transitory functional influence of calcium or para thormone on the dopamine turnover or post-synaptic dopamine receptor site (18,19), since her parkinsonian features improved after parathyroidectomy.…”
Section: Introductionmentioning
confidence: 83%