Central Nervous System Involvement in Burkitt’s Lymphoma

Ziegler, John L.; Bluming, Avrum Z.; Morrow, Richard H.; Fass, Leroy; Carbone, Paul P.

doi:10.1182/blood.v36.6.718.718

Cited by 74 publications

(11 citation statements)

References 13 publications

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“…The convoluted cell type lymphoblastic ML frequently presented with enlargement of the mediastinum and bone marrow infiltration, whereas Burkitt type M L presented with involvement of abdominal structures. Similarly to that observed in endemic African Burkitt lymphoma, CNS involvement was also a common finding in our series [32] . Bone marrow infiltration and subsequent leukemia-like evolution were particularly frequent in the convoluted cell type and in the lymphoblastic (others) subgroups.…”

Section: Discussionsupporting

confidence: 90%

Childhood non‐Hodgkin malignant lymphomas: A clinicopathologic retrospective study

Gasparini

Fossati-Bellani

Lombardi

et al. 1979

Med. Pediatr. Oncol.

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Between 1968 and 1975, 44 evaluable children under 16 years of age with the histologic diagnosis of non-Hodgkin malignant lymphoma (ML) were treated at the Istituto Nazionale Tumori of Milan. Histologic diagnoses were reclassified as follows: 13 lymphoblastic (others) ML, 15 convoluted cell type lymphoblastic ML, 9 Burkitt type ML, and 7 immunoblastic ML. Only 36% of the patients had stage I and II disease. At diagnosis 25% showed malignant cells in the bone marrow smears. Bone marrow infiltration was particularly frequent in the convoluted cell type lymphoblastic ML and in the lymphoblastic (others) ML subgroups. Burkitt type ML frequently was associated with abdominal lesions and subsequently a high incidence of central nervous system involvement. Patients with stage I and II ML were encountered mostly in the immunoblastic ML subgroup. After 1973 more intensive chemotherapy plus radiotherapy seems to have slightly improved the survival of the patients, except in the Burkitt type ML Subgroup.

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Section: Discussionsupporting

confidence: 90%

Childhood non‐Hodgkin malignant lymphomas: A clinicopathologic retrospective study

Gasparini

Fossati-Bellani

Lombardi

et al. 1979

Med. Pediatr. Oncol.

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“…The sporadic variant of BL accounts for only 1–2% of Non-Hodgkin Lymphoma in adults and typically presents as an abdominal tumor 1 . Although central nervous system (CNS) involvement has been described previously, isolated sixth nerve palsy is rare 2 . We report binocular, horizontal diplopia due to isolated CN VI palsy as the presenting sign for CNS BL.…”

Section: Introductionmentioning

confidence: 80%

Sixth nerve palsy in sporadic Burkitt Lymphoma

Yennam

Kini

Othman

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeTo describe a unique presentation of Central Nervous System Burkitt Lymphoma.ObservationsA 59-year-old male presented with new onset binocular horizontal diplopia five days after initial presentation with abdominal distension, weight loss, and night sweats. He was diagnosed with Burkitt Lymphoma with base of skull metastasis that was initially visible only on PET scan and subsequently resolved with chemotherapy.Conclusions and ImportanceBurkitt Lymphoma (BL) is an aggressive type of B-cell, non-Hodgkin, lymphoma that arises due to a translocation of the MYC proto-oncogene. Although central nervous system (CNS) involvement has been described previously with BL, isolated sixth nerve palsy as the initial sign of CNS metastasis is rare. Suspicion should remain high for metastatic disease in patients presenting with acute-onset neurologic complaints even when initial imaging is negative as timely treatment can prevent poor outcomes.

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“…Burkitt lymphoma also frequently metastasizes to the CNS [54]. CNS disease developed in 46% of African patients [55] and 38% of US patients [45]. Few of our patients with convoluted lymphocytic or FCC lymphomas/leukemias received prophylactic treatment t o the CNS.…”

Section: Cns Involvementmentioning

confidence: 99%

Childhood leukemia and lymphoma: Correlation of clinical features with immunological and morphological studies

Quinn

Taylor

Swanson

et al. 1979

Med. Pediatr. Oncol.

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Malignant cells from 49 children with lymphoid neoplasms other than Hodgkin disease were evaluated by surface marker and morphologic studies. We classified the patients into three groups: 36 patients (74%) with acute lymphocytic leukemia; 7 (14%) classified as convoluted lymphocytic lymphoma/leukemia; and 6 (12%) with small noncleaved follicular center cell lymphoma/leukemia. Diffuse marrow involvement was present at diagnosis in some patients in the latter two groups, but their clinical course was not characteristic of the patients with acute lymphocytic leukemia. Male predominance, poor prognosis, and high incidence of central nervous system disease characterized patients in the convoluted lymphocytic and follicular center cell lymphoma/leukemia groups. Clinical presentation in these two groups differed. Proliferations of convoluted lymphocytes were associated with mediastinal masses and proliferations of follicular center cells with intraabdominal tumors. The high incidence of CNS disease in children with neoplasms of convoluted lymphocytes and follicular center cells suggests that these processes have a predilection for the CNS and that patients with them may benefit from CNS prophylaxis.

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Central Nervous System Involvement in Burkitt’s Lymphoma

Cited by 74 publications

References 13 publications

Childhood non‐Hodgkin malignant lymphomas: A clinicopathologic retrospective study

Childhood non‐Hodgkin malignant lymphomas: A clinicopathologic retrospective study

Sixth nerve palsy in sporadic Burkitt Lymphoma

Childhood leukemia and lymphoma: Correlation of clinical features with immunological and morphological studies

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