1965
DOI: 10.1182/blood.v25.1.13.13
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Central Nervous System Involvement by Leukemia in Children. II. Therapy with Intrathecal Methotrexate

Abstract: 1. Thirty-six children with leukemic involvement of the CNS were treated with one to seven courses of methotrexate given intrathecally. a. Complete or partial symptomatic relief occurred in 57 of 67 episodes treated. b. Onset of improvement ranged from immediately after the initial lumbar puncture to 18 days later. c. Duration of response, with complete relief from symptoms, ranged from eight to 751 + days, median 84 days. d. Median values for CSF pre… Show more

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Cited by 46 publications
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