Central nervous system hemangioblastomas: Epidemiology, pathology and clinical spectrum in a tertiary care centre

Chawhan, Sanjay M; Dani, Aarti A; Meshram, Saroj A; Narkhede, S.; Randale, Archana A; Kumbhalkar, Dinkar T

doi:10.4103/2349-0977.157762

Cited by 2 publications

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“…Because of the rich network of blood vessels and the cytoplasm of stromal cells are clear, it is necessary to distinguish hemangioblastoma from vascular tumor as well as clear cell meningioma. 2 Hemangioblastoma occurs mainly in the cerebellum, brain stem, and spinal cord, 3 and rarely in the supratentorial region. 4 Hemangioblastoma in the cerebrum has rarely been described in the literature, and its epidemiological data are limited.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Hemangioblastoma Without Von Hippel-Lindau Syndrome: A Report of 6 Cases

et al. 2020

Int J Surg Pathol

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Background. Hemangioblastoma occurs mainly in the cerebellum and rarely in the cerebrum. Objective. The present study aimed to analyze the clinical manifestations and radiological and pathological features of cerebral hemangioblastoma, and to improve the recognition of this tumor and avoid misdiagnosis. Methods. The characteristics of 6 patients with cerebral hemangioblastoma were analyzed, and a retrospective review of cerebral hemangioblastoma reported in the literature was performed. Results. All 6 patients were female, aged from 22 to 70 years (55 years on average), and all cases were wild-type sporadic, in which 4 cases occurred in the frontal lobe and 2 cases occurred in the parietal lobe. Imaging revealed a solid tumor in 4 cases, a cystic tumor in 1 case, and a mixed tumor in 1 case. Microscopically, the morphology and immunophenotype of tumor cells were not different from those of classical hemangioblastoma. All 6 patients survived tumor free during the follow-up period. Conclusions. Cerebral hemangioblastoma often simulates the imaging characteristics of meningioma or glioma. Enough attention should be paid to differential diagnosis before the operation, and exact diagnosis relies on the pathological examination.

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Section: Introductionmentioning

confidence: 99%