Central Nervous System Depressants--III. 2- and 4-Allyloxy-3,5-Disubstituted Benzoic Acids and Derivatives

Abstract

In the preceding articles,1,2 it was reported that a considerable number of 4-allyloxy-3,5-dialkylbenzoic acids, esters, amides and nitriles (I; R = propyl, isopropyl, ethyl and methyl) greatly increase the sleeping time of mice given small doses of hexobarbital. We have now extended the series by replacing the alkyl groups with halogens (I; R = chlorine or iodine) and by the introduction of a methyl group into the 2-position (II).(II) Furthermore, we have prepared a series of analogues in which the allyloxy group is in the 2-position instead of the 4-positionAlthough many of these compounds were highly active, they were in general less active than the corresponding derivatives described in the preceding articles.1,2 * Presented in part before the Division of Medicinal Chemistry, American

Microwave‐assisted extraction (MAE) combined with gas chromatography–mass spectrometry (GC–MS) for determination of volatile small molecules to evaluate compatibility of antimicrobial peptide PL‐5 spray with packaging materials

“…The LODs of the three volatile small molecules (DBB, DBP, DBHBA) were 0.99, 16.34, and 1.64 ng/mL, respectively. According to the previous reports about the National Institute for Occupational Safety and Health (NIOSH), the LD 50 (X) of DBP and DBHBA was 2400 mg/kg/day (rat, oral) and 1000 mg/kg/day (mouse, intraperitoneal), respectively (The National Institute for Occupational Safety and Health, ; Moffett & Seay, ). The formula to calculate the permitted daily exposure (PDE) for human is as follows (US Department of Health and Human Services Food and Drug Administration, ): where NOEL (no‐observed‐effect level) means the highest dose of substance at which there are no biologically significant increases in the frequency or severity of any effects in the exposed humans or animals.…”