Central nervous system damage in IgG4-related disease: review

Abstract

IgG4-related disease is a new and recently described and determined disease involving multiple organs. Its etiology and pathogenesis are still not fully understood. However according to multiple studies this disease should be considered as a unique pathological autoimmune unity involving various organs and tissues. IgG4-reladted disease was first considered as a form of pancreatic inflammatory process and diagnosed as IgG4-related autoimmune pancreatitis. However current data demonstrate the potential involvement of almost all tissues and organs including central nervous system. Diagnostic criteria are being reviewed annually resulting in IgG4-related disease diagnosis in many considered differently cases. This review presents current literature data related to IgG4-related disease etiology and pathogenesis, diagnostic criteria and potential forms of central nervous system IgG4-related injury.