Central Nervous System Complications of Sickle Cell Disease in Children: An Overview

Wang, Winfred C.

doi:10.1080/09297040600788136

Cited by 30 publications

(35 citation statements)

References 84 publications

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“…[1][2][3] Of all children with hemoglobin SS SCD, 10% to 15% have overt strokes by the age of 15, and 20% to 25% have silent (subclinical) strokes. 4,5 Neuropsychological testing is particularly sensitive for detecting silent strokes, 6 which are associated with impaired executive function (concentration, working memory, planning and organization, and mental efficiency) and mildly diminished general intelligence.…”

Section: Scd-related Medical and Neuropsychological Complicationsmentioning

confidence: 99%

Transition Planning for Youth With Sickle Cell Disease: Embedding Neuropsychological Assessment Into Comprehensive Care

et al. 2010

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OBJECTIVE: Sickle cell disease (SCD) conveys a high risk of neuropsychological impairment due to chronic anemia, hypoxemia, cerebrovascular ischemia and stroke, in addition to causing pain and other biomedical complications. Few families accessed neuropsychological testing via the traditional referral system. In this paper, we describe a successful alternative strategy for addressing cognitive and behavioral needs of youth with SCD.

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Section: Scd-related Medical and Neuropsychological Complicationsmentioning

confidence: 99%

Transition Planning for Youth With Sickle Cell Disease: Embedding Neuropsychological Assessment Into Comprehensive Care

et al. 2010

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“…A maior dos pacientes utilizava hidroxiureia conforme protocolo clínico (CANÇADO et al, 2009) e realizava hemotransfusão, tratamentos definidos a partir de consensos clínico e científico (WANG, 2007). Na Tabela 1 são descritas as características socioeconômicas e clínicas dos casos.…”

Section: Resultsunclassified

Avaliação neuropsicológica abrangente de crianças e adolescentes com anemia falciforme e acidentes vasculares encefálicos: relato de casos

Nunes¹,

Nogueira²,

Toralles³

et al. 2016

cmbio

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ResumoIntrodução: em crianças e adolescentes com Anemia Falciforme, características específicas como anemia, hipoxemia crônica, infartos cerebrais e alterações nutricionais sobre o cérebro têm repercussão negativa no desenvolvimento neurocognitivo. Objetivo: avaliar inteligência, cognição e comportamento de crianças e adolescentes com Anemia Falciforme, acometidos por infartos cerebrais. Metodologia: estudo observacional, descritivo, tipo casuística hospitalar realizado com crianças e adolescentes com hemoglobinopatia do tipo Hb SS, idade 6 a 15 anos. Foi aplicado o questionário Critério Brasil de Classificação Socioeconômica. A avaliação neuropsicológica foi realizada através do teste NEPSY-II, o Quociente Intelectivo estimado foi obtido através das Escalas Weschsler de Inteligência-III e aplicado aos responsáveis o questionário Child Behavior Checklist, para avaliação comportamental. Discussão: nenhum paciente atingiu escores esperados para idade nos domínios avaliados, bem como não alcançou resposta dentro da média em todos subtestes de um domínio. Todos os casos apresentaram baixos índices de QI, indicando presença de déficit cognitivo global. Um indivíduo apresentou transtorno de ansiedade, depressão e problemas sociais. A ocorrência de infarto cerebral predispõe a alterações mais graves no desenvolvimento intelectivo e/ou cognitivo, reduzindo possibilidades de desenvolvimento acadêmico e de competitividade no mercado de trabalho. Conclusão: todos os pacientes demonstraram comprometimento cognitivo global. Nenhum paciente atingiu os escores esperados para idade em pelo menos um dos domínios avaliados.

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“…PRES is characterized by reversible radiographic signs of posterior leukoencephalopathy in the presence of headache, altered level of consciousness, and seizures with or without visual disturbances [5]. …”

Section: Discussionmentioning

confidence: 99%

Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome

Aiyer

Klein

El-Sherif

2016

Case Reports in Radiology

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We present a case of 29/m with a history of sickle cell disease who presented to the emergency department with sudden onset of chest, trunk, extremity, and back pain, consistent in quality and severity with the patient's usual pain crises. Soon after admission to the medical unit for acute chest syndrome (ACS), the patient developed sudden onset of hypertension associated with left sided hemiplegia, lethargy, dysarthria, aphasia, and left sided facial droop. Neuroimaging revealed that on MRI Brain there was multifocal extensive signal abnormality and a small focal areas of hemorrhage compatible with posterior reversible leukoencephalopathy syndrome (PRES). Patient was treated with levetiracetam and phenytoin and improved soon afterwards, with resolution seen on follow-up MRI two months later.

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Central Nervous System Complications of Sickle Cell Disease in Children: An Overview

Cited by 30 publications

References 84 publications

Transition Planning for Youth With Sickle Cell Disease: Embedding Neuropsychological Assessment Into Comprehensive Care

Transition Planning for Youth With Sickle Cell Disease: Embedding Neuropsychological Assessment Into Comprehensive Care

Avaliação neuropsicológica abrangente de crianças e adolescentes com anemia falciforme e acidentes vasculares encefálicos: relato de casos

Rare Case of Posterior Reversible Leukoencephalopathy Syndrome Secondary to Acute Chest Syndrome

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