Central Nervous System Complications in Patients Undergoing Chemotherapy

Psimaras, Dimitri; Leclercq, Delphine; Ricard, Damien; Delattre, J.

doi:10.1007/174_2014_1050

Cited by 2 publications

(1 citation statement)

References 128 publications

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“…Después de bajas dosis que ocurre tras la administración de metotrexato, se ha reportado disfunción cognitiva transitoria y alteración del estado de ánimo [4][5][6]30 .…”

Section: Metotrexatounclassified

Efectos adversos neuropsiquiátricos de drogas inmunosupresoras utilizadas en Reumatología

Chiappe¹,

Scublinsky²

2013

Rev. Argent. Reumatol.

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El uso de fármacos inmunosupresores ha ido incrementándose en las últimas décadas de la mano de un mayor conocimiento de la fisiopatología del sistema inmune y el desarrollo de la tecnología aplicada para generar drogas de alta complejidad. La utilización de dichos fármacos inmunosupresores puede producir como efecto adverso tanto manifestaciones neurológicas como psiquiátricas. El objetivo de esta revisión es describir los efectos adversos neuropsiquiátricos de las principales drogas inmunosupresoras usadas para el tratamiento de las enfermedades reumatológicas.

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“…Después de bajas dosis que ocurre tras la administración de metotrexato, se ha reportado disfunción cognitiva transitoria y alteración del estado de ánimo [4][5][6]30 .…”

Section: Metotrexatounclassified

Efectos adversos neuropsiquiátricos de drogas inmunosupresoras utilizadas en Reumatología

Chiappe¹,

Scublinsky²

2013

Rev. Argent. Reumatol.

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Chemotherapy-related neurotoxicity in pediatric cancer patients: magnetic resonance imaging and clinical correlation

Abdou

Kiki

Madney

et al. 2021

Egypt J Radiol Nucl Med

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Background Cancer is the second most common cause of death among children aged 1–14 years in the USA. Pediatric malignancies have elevated morbidity and mortality in the absence of proper treatment. Intensive treatment regimens have resulted in a significant increase in the number of survivors but also have been associated with the risk of developing neurotoxicity. The purpose of this study is to emphasize the role of advanced MRI techniques in the early detection of different chemotherapy neurotoxicities and make radiologists aware of them providing early management to prevent permanent damage. Results We evaluated 63 patients (43 males and 20 females), and their ages ranged from (2 to 17 years) with suspected chemotherapy-related neurotoxicity. MR examinations were performed with 1.5-T Philips systems. Clinical data were correlated with magnetic resonance imaging (MRI), and different treatment complications were diagnosed. All of our 63 patients were receiving chemotherapy treatment, and they developed different neurological symptoms. Patients diagnosed as posterior reversible encephalopathy syndrome were 41 with 8 patients had typical and 33 had atypical criteria, 16 patients diagnosed as cerebral venous sinus thrombosis with magnetic resonance venography (MRV) are the most important sequence that successfully diagnosed them, and finally, 6 patients diagnosed as methotrexate neurotoxicity with diffusion-weighted images (DWI) are the most important sequence for early diagnosis. Conclusion Chemotherapy is associated with certain neurotoxicities, conventional MRI can detect them, but by the use of advanced MRI techniques including MRV and DWI early detection of these neurotoxicities can occur. Therefore, the combination of conventional MRI together with advanced techniques improves the diagnostic efficacy of MRI in the early diagnosis of neurotoxicity.

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Central Nervous System Complications in Patients Undergoing Chemotherapy

Cited by 2 publications

References 128 publications

Efectos adversos neuropsiquiátricos de drogas inmunosupresoras utilizadas en Reumatología

Efectos adversos neuropsiquiátricos de drogas inmunosupresoras utilizadas en Reumatología

Chemotherapy-related neurotoxicity in pediatric cancer patients: magnetic resonance imaging and clinical correlation

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