2010
DOI: 10.1182/blood.v116.21.184.184
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Central Nervous System (CNS) Involvement In Pediatric Relapsed Acute Myeloid Leukemia: Results and Lessons From Study Relapsed AML 2001/01

Abstract: 184 Acute Myeloid Leukemia - Therapy, excluding Transplantation: Pediatric and Adult AML Therapy Introduction: With improving initial antileukemic therapy, CNS disease might become more important in AML. We therefore evaluated the incidence of CNS involvement in a large series of children with first relapsed AML. In addition, clinical and biological features of children with and without CNS involvement at relapse were compared, and finally the … Show more

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Cited by 3 publications
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“…The presence of NM is frequent during the course of AL not only at diagnosis as but also during relapses [ 22 , 23 ], which is in accordance to the results observed in the study population. In particular, cases with NM tended to be older.…”
Section: Discussionsupporting
confidence: 89%
“…The presence of NM is frequent during the course of AL not only at diagnosis as but also during relapses [ 22 , 23 ], which is in accordance to the results observed in the study population. In particular, cases with NM tended to be older.…”
Section: Discussionsupporting
confidence: 89%
“…It is generally considered that AML cells rarely reach the CNS and develop tumors, (23,24), whereas in pediatric patients (25) this is a common event. This pattern might not accurately reflect the reality, as many times CNS involvement in adults remains undiagnosed (12,23).…”
Section: Background On the Central Nervous Systems (Cns) Involvement In Acute Leukemiasmentioning
confidence: 99%