Central nervous respiratory depressants—narcotic analgesics

Borison, Herbert L.

doi:10.1016/0306-039x(77)90034-4

Cited by 15 publications

(13 citation statements)

References 89 publications

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“…5C). Since opiates have been shown to affect tidal volume as well as respiratory frequency (Borison, 1977;Mather and Smith, 1999), we analyzed tidal volume levels and found no differences between the two genotypes at any of the doses tested (data not shown). Therefore, changes in tidal volume could not account for the genotype differences observed in breathing frequency.…”

Section: Morphine Side Effects In ␤-Arrestin 2 Knockout Mice 1197mentioning

confidence: 99%

Morphine Side Effects in β-Arrestin 2 Knockout Mice

Raehal¹,

Walker²,

Bohn³

2005

J Pharmacol Exp Ther

541

496

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Morphine is a potent analgesic, yet, like most opioid narcotics, it exerts unwanted side effects such as constipation and respiratory suppression, thereby limiting its clinical utility. Pharmacological approaches taken to preserve the analgesic properties, while eliminating the unwanted side effects, have met with very limited success. Here, we provide evidence that altering opioid receptor regulation may provide a novel approach to discriminate morphine's beneficial and deleterious effects in vivo. We have previously reported that mice lacking the G protein-coupled receptor regulatory protein, ␤-arrestin 2, display profoundly altered morphine responses. ␤-Arrestin 2 knockout mice have enhanced and prolonged morphine analgesia with very little morphine tolerance. In this report, we examine whether the side effects of morphine treatment are also augmented in this animal model. Surprisingly, the genetic disruption of opioid receptor regulation, while enhancing and prolonging analgesia, dramatically attenuates the respiratory suppression and acute constipation caused by morphine.

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Section: Morphine Side Effects In ␤-Arrestin 2 Knockout Mice 1197mentioning

confidence: 99%

Morphine Side Effects in β-Arrestin 2 Knockout Mice

Raehal¹,

Walker²,

Bohn³

2005

J Pharmacol Exp Ther

541

496

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“…Opiates are also known to influence qrstems related to thermoregulation (Adler et al, 1980;Clark, 1979;Frohm & Wallnau, 1983) and respiration (Butland et al, 1981;Borison, 1977;Eckenhoff & Oech, 1960). In mammals, opiate agonists lower core bo<fy temperature (Tam, 1989) and depress respiration (Green, 1959;Ling, %)iegel, Lockhart, & Pasternak, 1985;McGilliard & Takemori, 1978;McQueen, 1983) through mu receptor activation.…”

mentioning

confidence: 99%

Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl

Sufka

Hughes

Giordano

1991

Pharmacology Biochemistry and Behavior

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Sufka, Kenneth Joseph, "Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl " (1990 INFORMATION TO USERSThe most advanced technology has been used to photograph and reproduce this manuscript from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order.

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“…This indi cates that the endogenous enkephalins as well as the exogenous opiates [6] have indepen dent actions on the frequency and tidal vol ume control mechanisms of the respiratory center.…”

Section: Discussionmentioning

confidence: 99%

“…The respiratory depressant effect of mor phine and various exogenous opiate agonists is well recognized and described [6].…”

Section: Discussionmentioning

confidence: 99%

Transient Apnea after an Enkephalin Analogue in the Preterm Rabbit

Hedner¹,

Hedner²,

Bergman³

et al. 1981

Neonatology

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FK 33–824, a potent enkephalin analogue was administered systemically, 0.5–5 mg/kg, to preterm neonatal rabbits. A marked decrease in respiratory frequency as well as irregular breathing and apneic spells was recorded at 5 mg/kg. Tidal volume was not affected. The enkephalin-induced respiratory depression was restored immediately after naloxone (10 mg/kg). Based on the results it may be speculated upon whether brain stem enkephalin neurons are involved in the pathogenesis of neonatal transient apnea and irregular breathing.

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Central nervous respiratory depressants—narcotic analgesics

Cited by 15 publications

References 89 publications

Morphine Side Effects in β-Arrestin 2 Knockout Mice

Morphine Side Effects in β-Arrestin 2 Knockout Mice

Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl

Transient Apnea after an Enkephalin Analogue in the Preterm Rabbit

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