Central nervous malformations in presence of clefts reflect developmental interplay

Mueller, Andreas; Sader, Robert; Honigmann, K; Zeilhofer, H.‐F.; Schwenzer-Zimmerer, K.

doi:10.1016/j.ijom.2006.10.018

Cited by 19 publications

(25 citation statements)

References 17 publications

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“…Yet another study of 245 patients revealed that patients with CLP were 13 times more likely than the general population to possess a central nervous system anomaly. The incidence of central nervous system anomalies in this study was 4.2% (Mueller et al, 2007). Thus, our finding of 6.3% of brain abnormalities in this cohort of fetuses with CL/P or CP is consistent with other studies.…”

Section: Discussionsupporting

confidence: 92%

Magnetic Resonance Imaging for Detection of Brain Abnormalities in Fetuses with Cleft Lip and/or Cleft Palate

Rosen

Chiou

Stoler

et al. 2011

The Cleft Palate-Craniofacial Journal

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Section: Discussionsupporting

confidence: 92%

Magnetic Resonance Imaging for Detection of Brain Abnormalities in Fetuses with Cleft Lip and/or Cleft Palate

Rosen

Chiou

Stoler

et al. 2011

The Cleft Palate-Craniofacial Journal

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“…These findings are in accordance with the study by Person on educational difficulties in adolescents with a cleft [22]. Apropos of this, Mueller et al Point to the interplay of craniofacial and brain development, which might explain learning disabilities [23].…”

Section: Discussionsupporting

confidence: 90%

A Clinical Report: Mental health, Self-esteem and Social Interaction in Adolescents with CL/P in the Context of Re-constructive Surgery

Niemelä¹,

Skoog²,

Henriksson³

et al. 2012

J Depress Anxiety

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otoplasty surgery. However, the question of (self assessed) self-esteem remains unanswered, as it seems unaffected by reconstructive surgery The Current StudyThe aim of the study was to continue the search for new ways of conceptualizing of self-esteem by asking adolescents to look back on changes in the levels of their self-esteem that can be meaningfully connected to age-related life experiences and context, such as, for instance reconstructive surgery. [17,18,19] In this study we focused on young patients with cleft-lip and palate (CLP) during the final stages of reconstructive surgery. At this stage in the process, the initial steps of medically necessary interventions had been dealt with and now the more aesthetic part of the treatment was on the agenda. Plastic surgeons involved in this field often ask themselves why some adolescents ask for surgery while others do not. Is this a question of mental health or pressure from others?A pilot study was performed with the aim of exploring important Abstract Background: Self-esteem in children and adolescents with deviances in function and appearance has been studied with diverse results. The effect of cleft lip/ and palate on mental health, self-esteem and social interaction were studied in the context of reconstructive surgery. Comparing parents' and children's' self-esteem reports was also of interest. Exploring these differences could help the understanding of future mental health in patients with CL/P and their need for reconstructive surgery. Methods:A descriptive study within an in-patient setting, Plastic Surgery Clinic, Uppsala University Hospital. Twenty-six CL/P patients between 13 and 19 years of age and their parents answered a specific condition questionnaire specially adapted for this study and Beck's Youth Inventories the day before reconstructive surgery.Results: Mental health was affected while self-esteem was on a median-high level for this CL/P group. Parents rated their children to have higher self-esteem as they grew older. However, females reported a diminished level from primary to secondary school age. Attention on CLP was high. Twenty-three adolescents, or 85 % of resondents, wanted to change their appearance, Conclusion: Mental health was affected by CL/P, especially for those children that had been bullied. Specifically, the wish to change appearance was associated with high level of anxiety and depression. The specific condition questionnaires proved to be more informative than the standardized measure regarding self-esteem under development for the sake of differentiating between parent-adolescent estimation of self-esteem.

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“…Birth defects often affect a combination of organs, and a triad of defects in the craniofacial region, the central nervous system, and the musculoskeletal system is particularly common (4,39). This is likely due to the shared ectodermal origins of these systems, or a result of the interplay between the ectoderm and mesoderm (5,39). Children with ICLP are more likely to suffer from a general developmental delay that affects multiple organ systems (39).…”

Section: Resultsmentioning

confidence: 99%

“…This is likely due to the shared ectodermal origins of these systems, or a result of the interplay between the ectoderm and mesoderm (5,39). Children with ICLP are more likely to suffer from a general developmental delay that affects multiple organ systems (39). Abnormalities in one system should therefore be evaluated in the context of possible multiple systems.…”

Section: Resultsmentioning

confidence: 99%

Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

et al. 2012

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INTRODUCTION Individuals with isolated cleft lip and/or palate (ICLP) are often reported to be of shorter stature relative to peers, and the objective of this study was to explore the role of the pituitary in relationship to growth. METHODS Fifty-five males and 32 females with ICLP were compared to 121 healthy males and 158 healthy females with respect to height and BMI. Magnetic resonance imaging (MRI) scans were obtained from all ICLP participants and 47% of healthy group participants. RESULTS Males with ICLP were shorter than healthy males and had lower BMI. However, the trajectories for height and BMI did not differ between groups. Analyses in a separate sample of adult males suggested that height normalizes in males with ICLP in their early 30s. There were no differences in mean pituitary volume and pituitary trajectories between male groups. Females with ICLP were shorter than healthy females and also had slower growth rates. They did not differ in mean BMI or BMI trajectories. Furthermore, there were no differences in mean pituitary volume, or in pituitary trajectories. DISCUSSION Our findings suggest that there are no gross morphological differences in pituitary volume in individuals with ICLP, although more subtle differences may exist.

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Central nervous malformations in presence of clefts reflect developmental interplay

Cited by 19 publications

References 17 publications

Magnetic Resonance Imaging for Detection of Brain Abnormalities in Fetuses with Cleft Lip and/or Cleft Palate

Magnetic Resonance Imaging for Detection of Brain Abnormalities in Fetuses with Cleft Lip and/or Cleft Palate

A Clinical Report: Mental health, Self-esteem and Social Interaction in Adolescents with CL/P in the Context of Re-constructive Surgery

Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate

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