Central mucoepidermoid carcinoma of the maxilla with unusual ground glass appearance and calcifications: A case report

Serpa

J Oral Maxillofac Pathol

et al. 2016

Central mucoepidermoid carcinoma (CMC) of the jaw bones is a rare malignant salivary gland tumor of unknown pathogenesis, comprising about 4% of all mucoepidermoid carcinomas (MECs). Most cases are histologically classified as a low-grade tumor and radiographically appear as a well-defined unilocular or multilocular radiolucent lesion. Block resection or wide local excisions are the treatment of choice and patients usually show a good overall prognosis although a long-term follow-up is necessary. This report describes a case of a 28-year-old male with MEC in the posterior region of the mandible and discusses its clinical, radiographic and histopathological findings. Although rare, CMC may be considered a differential diagnosis in cases of proliferative and osteolytic lesions in the oral cavity even when its clinical and/or radiographic findings do not suggest malignancy.

Section: Discussionmentioning

confidence: 99%

Central mucoepidermoid carcinoma radiographically mimicking an odontogenic tumor: A case report and literature review

Serpa

J Oral Maxillofac Pathol

et al. 2016

“…Mucoepidermoid carcinoma shows wide and diverse biological behavior, [28,29] therefore, MEC demands better understanding of its pathobiology and development of new mechanism-based therapies. [5,6] Therefore we tried to find a role of the proliferation marker (Ki67), the cancer stem cell and adhesion molecule (CD44) and MRD-1 protein in the pathogenesis of MEC.…”

Section: Discussionmentioning

confidence: 99%

The impact of proliferation and cancer stem cell upon the resistence to chemotherapy in salivary mucopepidermoid carcinoma

Esmaeil

Ahmed

Mourad

et al. 2019

JST

Background and aim: Mucoepidermoid carcinoma is a common salivary tumor that affects both adults and children. Proliferation is one of the most fundamental biological processes of growth and maintenance of tissue homeostasis. CD-44 may be used as an indicator of aggressive behavior of some human malignancy. Multidrug resistance is one of the major obstacles for successful cancer chemotherapy. The present study was carried out for evaluation of the biological rules and the clinicopathological significance of Ki-67, CD-44 and MDR-1 expression in the different histopathological grades of MECs.Patients and methods: Eighty paraffin embedded MEC tissues were collected and classified to three groups according to their histological grades. Tissue sections were stained with Ki-67, CD-44 and MDR-1 then examined microscopically and analyzedstatistically.Result: High grade MEC cases showed the highest expression for Ki-67, CD-44 and MDR-1. Additionally, significant differences were found between the histopathological grades as well as between lymph node stages of the studied cases and the expression of the three utilized markers.Conclusion: Ki-67, CD-44 and MDR-1can be used to evaluate the degree of differentiation and to predict the prognosis of MECs, furthermore, high grade MEC cases with high proliferative indices might be resistant to chemotherapy.

“…The most common signs and symptoms are: asymmetry caused by intraosseous expansion [3,6,[8][9][10][11][12][15][16][17][18][19][20][21][22][23], pain [3,[8][9][10][11][18][19][20][21][22][23], higher tooth mobility [24], trismus [8,24], and bleeding [23]. The following are less frequently mentioned in the literature [11,22,24]: nasal congestion [17], headaches [17], tinnitus [10,25], loss of hearing [25], or diplopia [20], when it comes to the maxilla. In case of the mandible, high-grade tumors were causing paresthesia along with hypoesthesia of the lower lip and teeth (Vincent symptom) [23,26].…”

Section: Discussionmentioning

confidence: 99%

High-grade central mucoepidermoid carcinoma arising in an odontogenic cyst: a case report and review of the literature

Świerzy¹,

Szuta²,

Tomaszewska³

et al. 2018

jos

Central mucoepidermoid carcinoma (CMEC) is a very rare neoplasm comprising 2% to 4% of all mucoepidermoid carcinomas. We herby present an unusual case of high-grade CMEC of the maxilla of a 53-year-old male patient, who was referred to the Department of Oral Surgery by a general dentist due to accidentally detected on X-ray unilocular radiolucent lesion on the premolar region of the left maxilla. Intraoral examination revealed asymmetry of the vestibule with palpable swelling in the region of 24-26 with a positive fluctuation and crepitation. After CBCT examination and core needle biopsy, preliminary diagnosis of residual cyst was made, and the cystic lesion was excochleated. Histopathological examination revealed a high-grade CMEC. Patient was reported to the Department of Cranio-Maxillofacial Surgery, where he underwent a subtotal maxillectomy and selective neck dissection. The patient remains in follow-up, having had no recurrences during 12-month period after surgery.