2021
DOI: 10.1186/s13000-021-01124-0
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Central mucoepidermoid carcinoma arising directly from a glandular odontogenic cyst of the mandible: a case report

Abstract: Background Central mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jawbone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. Case presentation A 6… Show more

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Cited by 7 publications
(13 citation statements)
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“…MAML2 rearrangement in MEC is not specific to salivary gland origin, as MEC of other origins, such as thymus, lung, lacrimal gland, and uterine cervix, have also demonstrated MAML2 rearrangement [25][26][27][28]. Our literature review only identified nine reports/studies documenting the presence of MAML2 rearrangement in CMEC in 30 cases (Table 1) [10][11][12][13][14][15][16][17][18]. Of these, site and demographic information are provided for 25 cases [10,11,[13][14][15][16][17][18].…”
Section: Discussionmentioning
confidence: 99%
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“…MAML2 rearrangement in MEC is not specific to salivary gland origin, as MEC of other origins, such as thymus, lung, lacrimal gland, and uterine cervix, have also demonstrated MAML2 rearrangement [25][26][27][28]. Our literature review only identified nine reports/studies documenting the presence of MAML2 rearrangement in CMEC in 30 cases (Table 1) [10][11][12][13][14][15][16][17][18]. Of these, site and demographic information are provided for 25 cases [10,11,[13][14][15][16][17][18].…”
Section: Discussionmentioning
confidence: 99%
“…Our literature review only identified nine reports/studies documenting the presence of MAML2 rearrangement in CMEC in 30 cases (Table 1) [10][11][12][13][14][15][16][17][18]. Of these, site and demographic information are provided for 25 cases [10,11,[13][14][15][16][17][18]. The mandible represents 64% of cases, with 36% occurring in the maxilla [10,11,[13][14][15][16][17][18].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Central MEC is a rare intraosseous variant occurring in the jaws and represents only 2% to 4% of all MECs 10,11 . It occurs most frequently in the fourth and fifth decade of life, with a male to female ratio of 1:1.45 12 ; in 50% of cases, they are associated with odontogenic cyst or unbroken tooth 13 …”
Section: Introductionmentioning
confidence: 99%
“…10,11 It occurs most frequently in the fourth and fifth decade of life, with a male to female ratio of 1:1.45 12 ; in 50% of cases, they are associated with odontogenic cyst or unbroken tooth. 13 Several theories regarding its origin have been postulated. [14][15][16][17] The most worthy considered neoplastic transformation of the epithelial lining of odontogenic cysts to be the most plausible in tumor's development.…”
Section: Introductionmentioning
confidence: 99%