Central motor conduction after magnetic stimulation in diabetes

Moglia, A.; Arrigo, A; Maurelli, M.; Alfonsi, Enrico; Bodini, Alessandro; Lozza, Alessandro; Tenconi, Maria Teresa; Solerte, Sebastiano Bruno; Ferrari, Ettore

doi:10.1007/bf03028805

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…We report that a short duration (8 weeks) of sustained hyperglycemia/hypoinsulinemia produced a marked attenuation of cerebral corticalϪevoked forelimb motor responses with a significant reduction of motor area topography. This novel finding is consistent with previous reports of decreased hippocampal synaptic plasticity (19,20) and disruption of neuronal function (6,7,21,22) in diabetes. This study extends these observations and suggests that dysregulation of central glucose and insulin in patients with poorly controlled diabetes may result in altered cerebral corticospinal motor function.…”

supporting

confidence: 93%

Experimental Diabetes Attenuates Cerebral Cortical−Evoked Forelimb Motor Responses

et al. 2005

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Poorly controlled diabetes leads to debilitating peripheral complications, including retinopathy, nephropathy, and neuropathy. Chronic diabetes also impairs the central nervous system (CNS), leading to measurable deficits in cognition, somatosensory, and motor function. The cause of diabetes-associated CNS impairment is unknown. In this study, sustained hyperglycemia resulting from insulin deficiency was shown to contribute to CNS motor dysfunction. Experimental diabetes was induced in rats by streptozotocin (STZ) injection. CNS motor function was assessed by intracortical microstimulation of the sensorimotor cortex. Experimental diabetes significantly (P < 0.01; n ‫؍‬ 14) attenuated the number of motor cortical sites eliciting forelimb movements. The net area of the motor cortex representing the forelimb in diabetic rats was significantly reduced

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supporting

confidence: 93%

Experimental Diabetes Attenuates Cerebral Cortical−Evoked Forelimb Motor Responses

et al. 2005

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“…For descending corticospinal projections from M1, diffusion tensor imaging studies report decreases in microstructural integrity in the descending white matter of the CST (27)(28)(29)(30)(31), which relates to cortical atrophy in M1 (2). The conduction velocity of upper motor neurons of the CST is delayed in humans (32,33) and in rodent models of diabetes (34). Loss of microstructural integrity and delays in conduction velocity are indicative of neuronal loss or demyelination in this critical motor pathway.…”

Section: Somatosensory and Motor Cortexmentioning

confidence: 99%

Brain and Body: A Review of Central Nervous System Contributions to Movement Impairments in Diabetes

et al. 2019

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Diabetes is associated with a loss of somatosensory and motor function, leading to impairments in gait, balance, and manual dexterity. Data-driven neuroimaging studies frequently report a negative impact of diabetes on sensorimotor regions in the brain; however, relationships with sensorimotor behavior are rarely considered. The goal of this review is to consider existing diabetes neuroimaging evidence through the lens of sensorimotor neuroscience. We review evidence for diabetes-related disruptions to three critical circuits for movement control: the cerebral cortex, the cerebellum, and the basal ganglia. In addition, we discuss how central nervous system (CNS) degeneration might interact with the loss of sensory feedback from the limbs due to peripheral neuropathy to result in motor impairments in individuals with diabetes. We argue that our understanding of movement impairments in individuals with diabetes is incomplete without the consideration of disease complications in both the central and peripheral nervous systems. Neuroimaging evidence for disrupted central sensorimotor circuitry suggests that there may be unrecognized behavioral impairments in individuals with diabetes. Applying knowledge from the existing literature on CNS contributions to motor control and motor learning in healthy individuals provides a framework for hypothesis generation for future research on this topic.

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“…The study shows that central conduction time was significantly increased in diabetic subjects. 12 Toppish demonstrated that patients with diabetes mellitus had a significant reduction in attention. Attention deficit occurs maximally in hypoglycaemia.…”

Section: Discussionmentioning

confidence: 99%

Study of Auditory and Visual Reaction Time in Diabetics

Kulkarni¹

2019

jebmh

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BACKGROUND Reaction time is the time interval between application of stimulus and the response obtained. It includes the time taken for central delay. 1 It is an important parameter to evaluate nervous system. It is dependent on several factors starting from nerve conduction to coordinating system in our body including long term and recent memory learning ability, criticism, perception and visual-auditory skills. We wanted to evaluate the effects of diseases like diabetes on reaction time. METHODS In the present study, visual and auditory reaction time was studied in 50 diabetics and in 50 normal subjects. There was prolongation of reaction time in diabetes. In diabetes there is involvement of peripheral conduction because of neuropathy, decreased processing of information in central nervous system and decreased attention. Reaction times can be measured by a variety of techniques in the lab. The simplest test is to present a stimulus to a test subject and instruct the subject to press a button as fast as possible after the stimulus is perceived. Responses can be measured by using a response box. Often-used stimuli are either visual (e.g., a coloured dot that pops up at random times on a computer screen), measure the reaction time from stimulus presentation up to the moment the subject presses the button. Hence, obtained response latencies include peripheral sensory processes, central sensor motor processing in the brain, and motor output. We have used response analyser to the measure reaction time. RESULTS Visual reaction time in healthy subjects was 184.12 + 12.19 msec. In diabetics visual reaction time was 224.86 + 12.5 msec and auditory was 224.1+12.39 msec. CONCLUSIONS Reaction time is significantly prolonged in individuals with diabetes mellitus. These differences were statistically significant (p<0.005).

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Central motor conduction after magnetic stimulation in diabetes

Cited by 8 publications

References 28 publications

Experimental Diabetes Attenuates Cerebral Cortical−Evoked Forelimb Motor Responses

Experimental Diabetes Attenuates Cerebral Cortical−Evoked Forelimb Motor Responses

Brain and Body: A Review of Central Nervous System Contributions to Movement Impairments in Diabetes

Study of Auditory and Visual Reaction Time in Diabetics

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