Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine

Hsieh, Gin C.; Hollingsworth, Peter R.; Martino, Brenda; Chang, Ruidong; Terranova, Marc A.; O’Neill, Alyssa B.; Lynch, James J.; Moreland, Robert B.; Donnelly‐Roberts, Diana L.; Kolasa, Teodozyj; Mikusa, Joseph P.; McVey, Jill M.; Marsh, Kennan C.; Sullivan, James P.; Brioni, Jorge D.

doi:10.1124/jpet.103.057455

Cited by 92 publications

(62 citation statements)

References 37 publications

(56 reference statements)

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“…The size and direction of the acute behavioral changes are in agreement with previous reports, as observed in rats (Bitran and Hull, 1987;Hsieh et al, 2004;Hull et al, 1986;Paglietti et al, 1978;Tagliamonte et al, 1974), mice (Rampin et al, 2003) and men (Hagemann et al, 2003;Montorsi et al, 2003). Melis and Argiolas (1995), reviewing the available data, described the changes observed as an indication , deep and superficial layers of the prelimbic cortex (C and D) and the nucleus accumbens core and shell (E and F) of male rats that remained in the home-cage ("non-sex") or underwent a 30-min sexual behavior test with a receptive female ("sex").…”

Section: Behavioral Effects Of Apomorphinesupporting

confidence: 82%

“…Our data do not support their suggestion, since our animals received ample sexual experience during the pre-test sessions and the most rapid and sluggish animals were excluded from the behavioral tests of the present experiment. The data obtained in the present experiment show that apomorphine, rather than having an effect only in low sexually active animals, reduces the pre-ejaculatory behavior (mounts and intromissions) in normal sexually active animals, confirming previously reported data (Bitran and Hull, 1987;Hsieh et al, 2004;Hull et al, 1986;Paglietti et al, 1978;Tagliamonte et al, 1974) and implying dopamine receptors to be involved in pre-ejaculatory behavior.…”

Section: Behavioral Effects Of Apomorphinesupporting

confidence: 80%

“…However, the role of dopamine D 1 vs D 2 receptors is complex (Hull et al, 1992) and hard to define, because of conflicting findings (Paredes and Agmo, 2004). The possible involvement of dopamine D 4 receptors in the pro-erectile effects of apomorphine Brioni et al, 2004;Hsieh et al, 2004) may shed new light on the existing confusing situation.…”

Section: Medial Preoptic Nucleus (Fig 2e)mentioning

confidence: 99%

“…Apomorphine is a mixed dopamine receptor agonist (D 2 N D 1 N D 4 ), inducing changes in male sexual behavior in the rat (Bitran and Hull, 1987;Giuliano et al, 2002;Hsieh et al, 2004;Hull et al, 1986;Malmnas, 1973;Paglietti et al, 1978;Pehek et al, 1989;Tagliamonte et al, 1974) and mice (Rampin et al, 2003). In reviewing the available data, Melis and Argiolas (1995), described the changes observed as indicative for a lowered ejaculatory threshold.…”

Section: Introductionmentioning

confidence: 99%

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Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Olivier

Jong

Dederen

et al. 2007

European Journal of Pharmacology

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Apomorphine is a non-selective dopaminergic receptor agonist. Because of its pro-erectile effects, apomorphine is clinically used for treatment of erectile dysfunction. We investigated the effects of subcutaneous apomorphine administration (0.4 mg/kg rat) on sexual behavior and matinginduced Fos-expression following acute (day 1) or chronic apomorphine treatment (days 8 and 15) in sexually experienced male rats. Consistent facilitatory effects of apomorphine were observed in the reduced numbers of mounts and intromissions over time and an increased ejaculation frequency on day 1. The first post-ejaculatory interval, however, was lengthened, while other behavioral parameters were unaffected. Fosimmunoreactivity induced by acute apomorphine administration (barrel cortex, paraventricular hypothalamic nucleus, central amygdala and locus coeruleus) was strongly reduced after chronic administration. After mating, induction of Fos-immunoreactivity was observed in well-known areas like medial preoptic nucleus and the posterodorsal medial amygdaloid area. Apomorphine, however, reduced mating-induced Fosimmunoreactivity in the nucleus accumbens shell and prevented its occurrence in its core area. This remarkable apomorphine effect was not observed in any other brain area. We conclude that the behavioral (pro-erectile) effects of apomorphine are consistent over time, and that the diminished accumbens-Fos-immunoreactivity and the elongated post-ejaculatory interval may reflect a decreased response to remote cues from the estrus female.

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Section: Behavioral Effects Of Apomorphinesupporting

confidence: 82%

Section: Behavioral Effects Of Apomorphinesupporting

confidence: 80%

Section: Medial Preoptic Nucleus (Fig 2e)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Olivier

Jong

Dederen

et al. 2007

European Journal of Pharmacology

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“…7 Even though some groups had focused their research on central pathways in the past decades, 8-10 the brain as a potential therapeutic target has generally been ignored. 11 The introduction of apomorphine, a proerectile drug acting at supraspinal levels, in the clinical treatment of erectile dysfunction [12][13][14] and the recent case report of changes in penile erection following deep brain stimulation (DBS) of the thalamus has raised the question as to what extent direct central modulation of erection is possible. 12,13,15 Two patients suffering from intractable Tourette Syndrome (TS) underwent DBS of the thalamus.…”

Section: Introductionmentioning

confidence: 99%

Thalamus and penile erection

et al. 2004

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Penile erection is a complex neurovascular event. The neuronal system involved is often divided into a spinal (generator) and supraspinal (controller) network. Little is known about the supraspinal control. The recent finding of changes in penile erection following deep brain stimulation of the thalamus in two patients has raised the question as to what extent the thalamus is involved in erectile function. The thalamus has generally been regarded as a group of relay nuclei that served as a 'gate' for sexual information from the spinal cord towards higher centres. Recent evidence, however, suggests a more integrated regulatory function. Our review of the literature from 1960 until 2003 revealed 13 reports describing original data (preclinical and clinical). Various thalamic regions, varying from the midline thalamus to the posterior thalamus, have been reported to be activated during erection. The majority of the reports, however, showed that mainly the mediodorsal (MD) nucleus and the centromedian-parafascicular nucleus (Cm-Pf complex) are involved in penile erection. MD is the second largest nuclear aggregation located within the medial part of the thalamus. Anatomically, the MD is closely related to the Cm-Pf complex. The Cm-Pf complex is one of the most important relay stations in which the anterolateral spinothalamic pathway is further processed. This pathway is thought to transmit peripheral sexual sensations. On the whole, the present data on the role of the thalamus in erection are far from complete and future experiments are required to delineate its involvement.

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Dopaminergic Neurotransmission

Schetz

Sibley

2007

Handbook of Contemporary Neuropharmacology

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Dopamine is a neurotransmitter in the central and peripheral nervous systems where it regulates numerous physiological processes. Within the CNS, dopamine is known to regulate emotion, reward, cognition, memory, endocrine functions, and motor control. Alterations in dopaminergic transmission are known to be involved in the etiology and/or therapy of a number of neurological and psychiatric disorders including Parkinson's disease, Tourette's syndrome, attention deficit hyperactivity disorder, schizophrenia and substance use. One of the hallmarks of these disorders is that they are all treated with drugs that either enhance or impede dopaminergic transmission. Dopamine exerts its effects by binding to and activating five different receptor proteins that are members of the G protein‐coupled receptor (GPCR) family. These five receptors are made up of two subfamilies: D 1 ‐like D 2 ‐like. The D 1 and D 5 receptors comprise the D 1 ‐like subfamily while the D 2 , D 3 and D 4 receptors make up the D 2 ‐like subfamily. In general, the D 1 ‐like receptors stimulate the production of the ubiquitous second messenger cAMP whereas D 2 ‐like receptors suppress cAMP production and also couple to additional signaling pathways. Different therapeutic agents are known to selectively activate or inhibit each of the dopamine receptor subtypes. A current goal of medicinal chemists is to develop drugs with even greater selectivity or specific mixed properties for the treatment of brain disorders that are associated with aberrations in various dopaminergic signaling pathways.

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Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine

Cited by 92 publications

References 37 publications

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat

Thalamus and penile erection

Dopaminergic Neurotransmission

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