Central liponeurocytoma: case report and review of literature

Does “cerebellar liponeurocytoma” always reflect an expected site? An unusual case with a review of the literature

“…The immunostaining profile of previously published cases of supratentorial liponeurocytomas demonstrates uniform reactivity for neuronal markers like synaptophysin, and/or NSE as was seen in the present case [2,[4][5][6]9,11,13,15]. Expression of GFAP and S-100 is limited to scattered reactive astrocytes [4,9,15], and a few tumour cells [2,5,11,13].…”

“…Linking the concept of liponeurocytoma to its occurrence in the cerebellum unnecessarily obscures the existence of similar neoplasms at other sites. Indeed ten such cases have been reported in the English literature (Table I) [2,[4][5][6]9,11,13,15]. We herein present the eleventh example of supratentorial intraventricular liponeurocytoma (Table I).…”

“…Expression of GFAP and S-100 is limited to scattered reactive astrocytes [4,9,15], and a few tumour cells [2,5,11,13]. The tumour cells are negative for NF [2,4,5,9,11,15]. MIB-1 labelling index was < 1% [2], 4% [11], 5.8% [4] and 15% and increased to 30% in the recurrent tumour [9].…”

“…This particular consistent evidence provides that lipid vacuoles progressively accumulate and coalesce within cells while retaining their neurocytic features. Thus, these distinctive lesions are a result of tumoral li pidization rather than true adipose metaplasia [4,5,9]. Some authors have interpreted this lipidization as true adipose metaplasia [15].…”

“…Tumours with features of liponeurocytoma have also been observed in supratentorial locations. There have been approximately 40 reported cases of cerebellar and 10 cases of supratentorial liponeurocytoma in the literature [2,[4][5][6]9,11,13,15]. The tumour usually has a favourable clinical prognosis, although recurrences are frequent [3,8].…”