Central Line Associated Blood Stream Infections in Pediatric Hematology/Oncology Patients With Different Types of Central Lines

Abstract

We found that CLABSI rates were significantly higher for inpatients compared to ambulatory PHO patients for all CL types. Among ambulatory patients, TECs had the highest CLABSI rate and ports the lowest. Among inpatients, TECs and PICCs had higher CLABSI rates than ports but were not statistically different from one another. Cognizant that host and underlying disease attributes may contribute to these differences, these results can still inform CL choice in clinical practice.

Incidence, severity and outcome of central line related complications in pediatric oncology patients; A single center study

“…The most common complications in this study were malfunctions, CLABSIs, and local infections. The incidence of CVAD-related complications in pediatric oncology patients per 1000 CVAD-days described in literature ranged from 0.8 to 2.0 for malfunctions, 0.1 to 1.6 for bloodstream infections related to the CVAD, and 0.1 to 0.3 for local infections [4][5][6][7][8][9][10][11]. The incidence of less common complications described in literature is comparable to that found in this study [5][6][7]9,12].…”

“…However, no significant difference was found in the incidence of severe neutropenia during CLABSIs in patients with HB-CVADs or TIVAPs. HB-CVADs were also found to be a risk factor for infections in other studies [4,8,[19][20][21]. Owing to the higher risk of CVAD-related complications associated with the HB-CVAD, the insertion of other double lumen CVADs (i.e.…”

“…Cultured during a local infection, n (%) the nonuniform complication criteria used, and the different CVADmaintenance protocols used (e.g. CVAD flush/lock protocols) [4][5][6][7][8][9][10][11]. Malfunction was the most common complication in this study.…”

Central line bundle including split-septum device and single-use prefilled flushing syringes to prevent port-associated bloodstream infections: a cost and resource-utilization analysis

“…Totally implantable venous access devices or implantable catheter ports are devices that can be implanted subcutaneously and enable continued or repeated access to the vascular system via veins. In a recent study from the United States, central line-associated blood stream infections (CLABSIs) associated with ports increased from 0.16 to 1.48 port days [2]. However, when they occur, they increase morbidity and mortality significantly [3,4].…”

How we infuse blinatumomab

“…The majority of our patients have infusaports. While broviacs and temporary peripherally inserted central catheters (PICCs) permit more flexibility around blood draws, they are also associated with an increased risk of infection and/or thrombosis 2‐4 . Our practice is not to place a temporary line as a second access during the infusion.…”