Central interleukin-1β-induced inhibition of acid secretion in rats: Specificity of action

Saperas, Esteban; Taché, Yvette

doi:10.1016/0024-3205(93)90076-f

Cited by 18 publications

(10 citation statements)

References 31 publications

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“…Interleukin-1β and TNF-α inhibit gastric acid secretion, providing a favorable condition for H pylori to survive in the stomach [12] . Although one study failed to show www.wjgnet.com inhibition of gastric acid secretion by IL-6 [13] , several studies have shown that gastric colonization with H pylori leads to elevated IL-6 levels in the gastric mucosa [14,15] . Thus, IL-6 may be one of the factors that maintain chronic infection with H pylori.…”

Section: Introductionmentioning

confidence: 99%

бH pylori�� seropositivity and cytokine gene polymorphisms

Saijo

Yoshioka²,

Fukui³

et al. 2007

WJG

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Section: Introductionmentioning

confidence: 99%

бH pylori�� seropositivity and cytokine gene polymorphisms

Saijo

Yoshioka²,

Fukui³

et al. 2007

WJG

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“…IL-1ra has been shown to bind to IL-1RI with an affinity approximating IL-1a and IL-1b, but does not induce signal transduction [18]. IL-1ra pre-treatment has also been shown to significantly reduce IL-1-mediated inflammatory damage in various experimental models, suggesting that these anti-inflammatory effects are receptor specific [19,20]. Although the IL-1 axis molecules, IL-RL1 (also known as T1/ST2) and IL-18RI, are not directly involved in IL-1 signalling, both are important markers of inflammation.…”

mentioning

confidence: 99%

Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle

Whelan

Kim²,

Chen³

et al. 2004

European Respiratory Journal

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Interleukin (IL)-1b is a pleiotropic, pro-inflammatory cytokine that has been importantly implicated in driving the inflammatory response and resultant changes in airway smooth muscle (ASM) responsiveness in asthma. IL-1b belongs to a family of molecules, known as the IL-1 axis, which exert both pro-and anti-inflammatory effects. Since dysregulation of IL-1 axis molecules may be critical in the pathobiology of asthma, the present study examined the expression and activation of both the inhibitory and stimulatory IL-1 axis molecules in human ASM cells and their roles in modulating cytokine and immunoglobulin (Ig)E immune complex (IgE cx)-mediated changes in rabbit ASM constrictor and relaxant responsiveness.The results demonstrate the following. 1) Pre-treatment of isolated rabbit tracheal rings with the inhibitory IL-1 axis members, IL-1 receptor antagonist and IL-1 type-II receptor abrogated both IL-5-and IgE cx-induced changes in ASM responsiveness. 2) Administration of IL-5, IL-1b and IgE cxs to human ASM cells increased mRNA and protein expressions of both stimulatory and inhibitory IL-1 axis molecules.3) The time course of IL-5-induced IL-1 axis molecule expression preceded that of both IL-1b and IgE immune cxs.Collectively, these findings suggest that modulation at the level of the interleukin-1 axis of molecules may have significant therapeutic potential in the treatment of asthma.

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“…administrations of either IL-1ß or IL-6 induce central effects such as fever, activation of the hypothalamic-pituitary-adrenal axis and anorexia [16], IL-1ß and IL-6 have divergent actions in the living system. For instance, unlike IL-6, IL-1ß enhances norepinephrine turnover in the spleen and hypothalamus [17,18], inhibits gastric acid secretion [19] and impairs spatial learning in the Morris water maze [20]. Under the present experimental conditions, both i.c.v.…”

Section: Discussionmentioning

confidence: 73%

Impairment of the Correlation between Urinary Contents of Alpha-1-Microglobulin and Ulinastatin Is Induced by Intracerebroventricularly Administered Interleukin-6 in Mice

Kaku¹,

Shikimi

Inagaki³

et al. 1999

Neuropsychobiology

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We have found previously that the correlation between urinary contents of alpha-1-microglobulin (α1M) and ulinastatin (UT) depends on the type of neuropsychiatric disease. Since interleukin (IL)-1β and IL-6 are closely involved in pathophysiological aspects of various neuropsychiatric diseases, effects of intracerebroventricularly (i.c.v.) administered IL-1β and IL-6 on the correlation between urinary contents of these two glycoproteins were examined in mice, a species in which α1M and UT and also the correlation between the urinary contents thereof are expressed similarly to humans. Indices (volume, contents of creatinine, α1M and UT, and α1M/UT ratio) in urine collected after i.c.v. administrations of 2 and 20 ng of either IL-1β or IL-6 were not statistically different from those of the vehicle-treated (control) groups. Neither IL-1β (2 and 20 ng) nor the lower dose of IL-6 (2 ng) affected the positive correlation between urinary contents of α1M and UT. However, a higher dose of IL-6 (20 ng) nullified the positive correlation for 2 days after administration. Recovery to a positive correlation was thereafter displayed. These findings suggest that central IL-6 plays an important role in correlating urinary contents of α1M and UT without affecting the renal functions.

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Central interleukin-1β-induced inhibition of acid secretion in rats: Specificity of action

Cited by 18 publications

References 31 publications

бH pylori�� seropositivity and cytokine gene polymorphisms

бH pylori�� seropositivity and cytokine gene polymorphisms

Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle

Impairment of the Correlation between Urinary Contents of Alpha-1-Microglobulin and Ulinastatin Is Induced by Intracerebroventricularly Administered Interleukin-6 in Mice

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