Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

Kimura, Kumi; Tanida, Mamoru; Nagata, Naoto; Inaba, Yuka; Watanabe, Hitoshi; Nagashimada, Mayumi; Ota, Tsuguhito; Asahara, Shun‐ichiro; Kido, Yoshiaki; Matsumoto, Michihiro; Koji, Takehiko; Nakazato, Masamitsu; Shibamoto, Toshishige; Kaneko, Shuichi; Kasuga, Masato; Inoue, Hiroshi

doi:10.1016/j.celrep.2016.02.032

Cited by 72 publications

(69 citation statements)

References 42 publications

(62 reference statements)

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“…The expression of the capsaicin-sensitive TRPV1, which is frequently co-localized with TRPA1, is commonly associated with this subtype of vagal sensory neurons (Nassenstein et al, 2008; Mazzone and Undem, 2016; Kollarik et al, 2010). These fibers with cell bodies in both the nodose and jugular ganglia, have different molecular phenotypes and central locations and are associated with different physiological responses (Kimura et al, 2016). The expression of Nav1.7, Nav1.8, and Nav1.9 has also been determined in vagal sensory neurons of nociceptor type, specifically in airways (Mazzone and Undem, 2016).…”

Section: The Immune Impact On Afferent Neuronal Functionmentioning

confidence: 99%

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

2017

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Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the inflammatory reflex and other neuro-immune interactions have greatly advanced understanding immunity, and identified new therapeutic possibilities in inflammatory and autoimmune diseases. Recent successful clinical trials using bioelectronic devices that modulate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel disease provide a path for using electrons as a therapeutic modality to target molecular mechanisms of immunity. Here we review mechanisms of peripheral sensory neuronal function modulation in response to immune challenges and neural regulation of immunity and inflammation, and discuss the therapeutic implications of this mechanistic insight.

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Section: The Immune Impact On Afferent Neuronal Functionmentioning

confidence: 99%

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

2017

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“…Nicotine is an alkaloid naturally produced by the tobacco plant that binds nicotinic acetylcholine receptors, found throughout neuronal and non-neuronal or visceral organs. These receptors participate in signaling within the central and peripheral nervous system and in a number of metabolic tissues, including pancreatic islets, adipose tissue, macrophages, liver, and skeletal muscle [14–17]. Nicotine has been shown to directly alter glucose homeostasis [18], suggesting an important role for this additive in the development of T2D.…”

Section: Smoking Leads To a Variety Of Chemical Exposuresmentioning

confidence: 99%

Smoking and the risk of type 2 diabetes

Maddatu

Anderson-Baucum

Evans‐Molina

2017

Translational Research

257

168

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Despite accumulating evidence demonstrating strong epidemiological and mechanistic associations between cigarette smoking, hyperglycemia, and the development of type 2 diabetes, tobacco abuse has not been uniformly recognized as a modifiable risk factor in diabetes prevention or screening strategies. In this review, we highlight population-based studies that have linked cigarette smoking with an increased risk of type 2 diabetes and summarize clinical and preclinical studies offering insight into mechanisms through which cigarette smoking and nicotine exposure impact body composition, insulin sensitivity, and pancreatic β cell function. Key questions for future studies are identified and strategies for smoking cessation as a means to decrease diabetes risk are discussed.

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“…These events eventually reduce HGP via the STAT3-mediated downregulation of genes such as glucose-6-phosphatase ( G6pc ), a gluconeogenic enzyme [79,80]. Recently, Kimura et al [81] demonstrated that the inhibition of hepatic gluconeogenic enzymes in response to central insulin signaling is mediated by the α 7 -nicotinic acetylcholine receptor (Fig. 1).…”

Section: Hypothalamic Insulin Signaling and The Regulation Of Hepaticmentioning

confidence: 99%

Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis

Chen

Balland

Cowley³

2017

Neuroendocrinology

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The central link between obesity and type 2 diabetes is the development of insulin resistance. To date, it is still not clear whether hyperinsulinemia causes insulin resistance, which underlies the pathogenesis of obesity-associated type 2 diabetes, owing to the sophisticated regulatory mechanisms that exist in the periphery and in the brain. In recent years, accumulating evidence has demonstrated the existence of insulin resistance within the hypothalamus. In this review, we have integrated the recent discoveries surrounding both central and peripheral insulin resistance to provide a comprehensive overview of insulin resistance in obesity and the regulation of systemic glucose homeostasis. In particular, this review will discuss how hyperinsulinemia and hyperleptinemia in obesity impair insulin sensitivity in tissues such as the liver, skeletal muscle, adipose tissue, and the brain. In addition, this review highlights insulin transport into the brain, signaling pathways associated with hypothalamic insulin receptor expression in the regulation of hepatic glucose production, and finally the perturbation of systemic glucose homeostasis as a consequence of central insulin resistance. We also suggest future approaches to overcome both central and peripheral insulin resistance to treat obesity and type 2 diabetes.

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Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor

Cited by 72 publications

References 42 publications

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Smoking and the risk of type 2 diabetes

Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis

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