Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala

Brown, Zenya J.; Nóbrega, José N.; Erb, Suzanne

doi:10.1016/j.bbr.2010.09.025

Cited by 28 publications

(24 citation statements)

References 31 publications

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“…Both ␤ 1 and ␤ 2 receptors are highly expressed in the mouse BNST (Lorton and Davis, 1987), and intra-BNST delivery of a cocktail of ICI-118,551 and betaxolol blocks stress-induced reinstatement in rats (Leri et al, 2002). In the BNST, norepinephrine enhances excitatory neurotransmission through actions at ␤ receptors (Egli et al, 2005) via a mechanism that may involve corticotrophin-releasing factor (CRF) (Nobis et al, 2011), consistent with the finding that intra-BNST CRF delivery induces cocaine seeking, whereas CRF receptor antagonism in the BNST prevents stress-induced reinstatement (Erb and Stewart, 1999), and with reports that CRF is downstream from norepinephrine in the pathway that mediates stress-induced reinstatement (Brown et al, 2011). Adrenergic receptor-regulated GABAergic inputs to the ventral tegmental area (VTA) have been characterized (Dumont and Williams, 2004).…”

Section: Discussionsupporting

confidence: 81%

“…In rodent and nonhuman primate models, central delivery of norepinephrine (Brown et al, 2011) or activation of central noradrenergic neurotransmission via antagonism of ␣ 2 adrenergic receptors (Lee et al, 2004;Feltenstein and See, 2006) reinstates extinguished cocaine seeking. Likewise, functional antagonism of noradrenergic neurotransmission through the administration of ␣ 2 adrenergic receptor agonists blocks stress-induced reinstatement in preclinical models (Erb et al, 2000) and attenuates stress-induced craving in human cocaine addicts (Jobes et al, 2011;Fox et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors

Vranjkovic¹,

Hang²,

Baker³

et al. 2012

J Pharmacol Exp Ther

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Stress can trigger the relapse of drug use in recovering cocaine addicts and reinstatement in rodent models through mechanisms that may involve norepinephrine release and ␤-adrenergic receptor activation. The present study examined the role of ␤-adrenergic receptor subtypes in the stressor-induced reinstatement of extinguished cocaine-induced (15 mg/kg i.p.) conditioned place preference in mice. Forced swim (6 min at 22°C) stress or activation of central noradrenergic neurotransmission by administration of the selective ␣ 2 adrenergic receptor antagonist 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole (BRL-44,408) (10 mg/kg i.p.) induced reinstatement in wild-type, but not ␤-adrenergic receptor-deficient Adrb1/Adrb2 double-knockout, mice. In contrast, cocaine administration (15 mg/kg i.p.) resulted in reinstatement in both wild-type and ␤-adrenergic receptor knockout mice. Stress-induced reinstatement probably involved ␤ 2 adrenergic receptors. The ␤ 2 adrenergic receptor antagonist -(isopropylamino)-1-[(7-methyl-4-indanyl)oxy]butan-2-ol (ICI-118,551) (1 or 2 mg/kg i.p.) blocked reinstatement by forced swim or BRL-44,408, whereas administration of the nonselective ␤-adrenergic receptor agonist isoproterenol (2 or 4 mg/kg i.p.) or the ␤ 2 adrenergic receptor-selective agonist clenbuterol (2 or 4 mg/kg i.p.) induced reinstatement. Forced swim-induced, but not BRL-44,408-induced, reinstatement was also blocked by a high (20 mg/kg) but not low (10 mg/kg) dose of the ␤ 1 adrenergic receptor antagonist betaxolol, and isoproterenol-induced reinstatement was blocked by pretreatment with either ICI-118,551 or betaxolol, suggesting a potential cooperative role for ␤ 1 and ␤ 2 adrenergic receptors in stress-induced reinstatement. Overall, these findings suggest that targeting ␤-adrenergic receptors may represent a promising pharmacotherapeutic strategy for preventing drug relapse, particularly in cocaine addicts whose drug use is stress related.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors

Vranjkovic¹,

Hang²,

Baker³

et al. 2012

J Pharmacol Exp Ther

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“…Together, these observations indicate that NE signaling is necessary for the ability of stress to reinstate previously extinguished drug seeking. Consistent with this, evidence demonstrates that increases in NE signaling are sufficient to reinstate psychostimulant- (Lee et al, 2004; Brown et al, 2009; Mantsch et al, 2010; Brown et al, 2011; Schroeder et al, 2013), and alcohol-seeking (Lê et al, 2005). Collectively, these observations indicate a significant role for NE in stress-related relapse of drug seeking.…”

Section: Arousal-related Ne Contributions To Motivated Behaviormentioning

confidence: 67%

Norepinephrine at the nexus of arousal, motivation and relapse

2016

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Arousal plays a critical role in cognitive, affective and motivational processes. Consistent with this, the dysregulation of arousal-related neural systems is implicated in a variety of psychiatric disorders, including addiction. Noradrenergic systems exert potent arousal-enhancing actions that involve signaling at α1- and β-noradrenergic receptors within a distributed network of subcortical regions. The majority of research into noradrenergic modulation of arousal has focused on the nucleus locus coeruleus. Nevertheless, anatomical studies demonstrate that multiple noradrenergic nuclei innervate subcortical arousal-related regions, providing a substrate for differential regulation of arousal across these distinct noradrenergic nuclei. The arousal-promoting actions of psychostimulants and other drugs of abuse contribute to their widespread abuse. Moreover, relapse can be triggered by a variety of arousal-promoting events, including stress and re-exposure to drugs of abuse. Evidence has long-indicated that norepinephrine plays an important role in relapse. Recent observations suggest that noradrenergic signaling elicits affectively-neutral arousal that is sufficient to reinstate drug seeking. Collectively, these observations indicate that norepinephrine plays a key role in the interaction between arousal, motivation, and relapse.

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“…Interestingly, NE alone has been shown to reinstate cocaine seeking when administered intracerebroventricularly (Brown et al, 2009). The authors attributed this phenomenon to a stress effect because it was associated with activation of neurons in the BNST and central amygdala that are part of the brain's stress pathway (Brown et al, 2011).…”

Section: Self-administrationmentioning

confidence: 99%

Adrenaline Rush: The Role of Adrenergic Receptors in Stimulant-Induced Behaviors

Schmidt

Weinshenker

2014

Mol Pharmacol

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Psychostimulants, such as cocaine and amphetamines, act primarily through the monoamine neurotransmitters dopamine (DA), norepinephrine, and serotonin. Although stimulant addiction research has largely focused on DA, medication development efforts targeting the dopaminergic system have thus far been unsuccessful, leading to alternative strategies aimed at abating stimulant abuse. Noradrenergic compounds have shown promise in altering the behavioral effects of stimulants in rodents, nonhuman primates, and humans. In this review, we discuss the contribution of each adrenergic receptor (AR) subtype (a1, a2, and b) to five stimulant-induced behaviors relevant to addiction: locomotor activity, conditioned place preference, anxiety, discrimination, and self-administration. AR manipulation has diverse effects on these behaviors; each subtype profoundly influences outcomes in some paradigms but is inconsequential in others. The functional neuroanatomy and intracellular signaling mechanisms underlying the impact of AR activation/blockade on these behaviors remain largely unknown, presenting a new frontier for research on psychostimulant-AR interactions.

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Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala

Cited by 28 publications

References 31 publications

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors

Norepinephrine at the nexus of arousal, motivation and relapse

Adrenaline Rush: The Role of Adrenergic Receptors in Stimulant-Induced Behaviors

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Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala

Cited by 28 publications

References 31 publications

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β1 and β2 Adrenergic Receptors

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β1 and β2 Adrenergic Receptors

Norepinephrine at the nexus of arousal, motivation and relapse

Adrenaline Rush: The Role of Adrenergic Receptors in Stimulant-Induced Behaviors

Contact Info

Product

Resources

About

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors

β-Adrenergic Receptor Mediation of Stress-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Roles for β₁ and β₂ Adrenergic Receptors