Central inflammatory response to experimental stroke is inhibited by a neuroprotective dose of dietary soy

Shambayati, Maryam; Patel, Maharshi; Ma, Yonggang; Cunningham, Rebecca L.; Schreihofer, Derek A.

doi:10.1016/j.brainres.2014.09.042

Cited by 12 publications

(9 citation statements)

References 44 publications

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“…Ovariectomised Sprague-Dawley mice were divided into two groups, one fed with a soy-free diet and another one with a diet containing high levels of soy PhyEs for 5 weeks. Soy intake was associated with a reduced inflammatory response in the cerebral cortex after transient middle cerebral artery occlusion (Shambayati et al, 2014). Among PhyEs, pterostilbene (PTER), a dimethylated analogue of resveratrol found in grapes and berries, exhibits a neuroprotective role in H 2 O 2 -treated SY5Y cells, mainly through ERα stimulation, which presumably involves a positive regulation of anti-apoptosis Bcl-2 expression and the activation of the MAPK/ERK and PI3K/AKT signaling pathways (Song et al, 2015).…”

Section: Natural Xenoestrogensmentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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Section: Natural Xenoestrogensmentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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“…In addition, coumestrol is a phytoestrogen compound which has potential benefits for either prevention or therapeutics use against cerebral ischemia in males (45). In another study, it has been demonstrated that Soy dietary may play a role in the brain injury (46). Soy prevents memory impairment and brain tissue oxidative damage caused by ischemia in OVX rats (47).…”

Section: Discussionmentioning

confidence: 99%

Effect of Achillea millefolium aqueous extract on memory deficit and anxiety caused by stroke in ovariectomized rats

Jahromi

Imani

Nasehi

et al. 2019

J Herbmed Pharmacol

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Introduction: Some studies indicated that the decrease of estrogen level in menopausal woman results in increasing the risk of stroke. Although estrogen is a neuroprotective factor, high consumption of this compound may develop breast cancer and endometriosis. The present study investigated the effect of Achilles millefolium extract, containing estrogenlike compounds, on memory impairment and anxiogenic-like behaviors caused by cerebral ischemia in ovariectomized rats. Methods: Permanent middle cerebral artery ligation was performed, as a model for studying postmenopausal condition, in 48 female Wistar rats weighing 200-250 g. The aqueous extract of A. millefolium was prepared and gavaged for 4 weeks after inducing cerebral ischemia. Memory and anxiety-like behavior assessments were evaluated by step-through and elevated plus maze apparatus, respectively. Result: According to the results, cerebral ischemia in ovariectomized rats induced amnesia and anxiogenic-like behaviors which were restored by 7 mg/kg of A. millefolium aqueous extract. Furthermore, inactivation of estrogen receptors (ERs) by tamoxifen (100 µg/kg, intraperitoneally) blocked the restoration effect of A. millefolium on behaviors induced by cerebral ischemia. Conclusion: It could be concluded that, oral administration of A. millefolium extract is able to restore memory impairment and anxiogenic-like behaviors induced by ischemia via ERs in ovariectomized rat.

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“…The neuroprotective effect of estrogen in TBI animals has been suggested in our previous studies [7][8][9], and our recent study demonstrated that a soy diet can be neuropreventive in TBI [21], and also the estrogenlike activity of soy isoflavones has been indicated [11,12]. Therefore in this research, the neuroprotective effect of genistein, as an isoflavone of soy, in diffuse and severe experimental TBI was assessed.…”

Section: Introductionmentioning

confidence: 88%

“…Soy phytoestrogens have been introduced as an alternative to hormone replacement therapy, due to the deleterious effects of estrogen [10]. Soy isoflavones, such as genistein and daidzein have phytoestrogen properties [11,12] and can act as an estrogen receptor modulator or act through a non-estrogen receptor pathway [13].…”

Section: Introductionmentioning

confidence: 99%

Is genistein neuroprotective in traumatic brain injury?

Soltani

Khaksari

Jafari

et al. 2015

Physiology & Behavior

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The concerns about negative consequences of estrogen therapy have led to introduce other strategies to obtain estrogen's benefits in the brain. The present study tests the hypothesis that a major isoflavone of soy; genistein with estrogen-like activity can be neuroprotective in traumatic brain injury (TBI). The male Wistar rats were randomly divided to four groups: sham, TBI, vehicle and genistein. The TBI was induced by Marmarou method. The brain edema and the disruption of blood-brain-barrier (BBB) were evaluated 48 h post-TBI. Genistein (15 mg/kg) or dimethyl sulfoxide (DMSO) was injected i.p., twice after TBI. The intracranial pressure (ICP), the motor performance, and the beam-walk task (WB) were determined before trauma, on trauma day (D0), and first (D1) and second (D2) days post-TBI. Genistein inhibited a development of brain edema and a BBB permeability in TBI animals. An increase of ICP and a defect in motor and WB performance were showed following TBI, in all times evaluated. An increase of ICP induced by TBI was suppressed by genistein on D1 and D2 times. Genistein improved a motor disorder induced by TBI, on D1 and D2 times. Also an increase of traversal time in WB task was suppressed by genistein in TBI animals, on D1 and D2 times. The results of this study demonstrated that genistein can be neuroprotective in TBI. Genistein inhibited the disruption of BBB, the brain edema and the increase of ICP, and the disturbance of neurobehavioral performance in TBI.

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Central inflammatory response to experimental stroke is inhibited by a neuroprotective dose of dietary soy

Cited by 12 publications

References 44 publications

Risks and benefits related to alimentary exposure to xenoestrogens

Risks and benefits related to alimentary exposure to xenoestrogens

Effect of Achillea millefolium aqueous extract on memory deficit and anxiety caused by stroke in ovariectomized rats

Is genistein neuroprotective in traumatic brain injury?

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