Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia

Suárez-Roca, Heberto; Quintero, Luis; Ávila, Raquel; Medina, Sonia; Freitas, Maria de Lourdes; Cardenas, Ricardo

doi:10.1016/j.brainresbull.2013.11.003

Cited by 24 publications

(12 citation statements)

References 75 publications

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“…Exposure to repeated stress has produced alterations to hormonal release and nociception, particularly leading to post-stress hyperalgesia in animals and humans (Ibironke & Mordi, 2018;Suarez-Roca et al, 2014). The findings from the current study indicate increased nociception following exposure to a stressor but were not statistically significant.…”

Section: Traumatic Stress and Hyperalgesiacontrasting

confidence: 60%

Voluntary Chronic Exercise Decreases Nociceptive Responses Before and After a Traumatic Stressor

Mozingo

Baiamonte

Hollander

2019

JBLS

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Objective: The hypoalgesic effect of acute bouts of exercise on healthy participants has been well documented across a variety of exercise modalities. However, the effects of a long-term exercise regimen on nociception is fairly unknown. Furthermore, it is unclear if exercise can be an effective treatment for disorders such as posttraumatic stress disorder, which can be characterized by hyperalgesia. The purpose of the current study is to investigate the effects of chronic exercise on thermal nociception before and after a traumatic stressor.Methods: Twenty-four C57/B6 mice were separated into two groups with 12 animals performing voluntary wheel running over a 5 week period. All mice were assessed weekly to determine the effects of chronic exercise or rest on thermal nociception. After 4 weeks, animals were further divided into 4 groups according to exercise and traumatic stress exposure. All mice were exposed to a 15 minute predator odor paradigm with “no stress” animals being exposed to ambient air and “stress” animals exposed to bobcat urine. All mice were tested 48 hours post exposure for changes in thermal nociception.Results: Findings from this study yield support that chronic, voluntary exercise decreases thermal nociception in mice over a 4-week period before a traumatic stressor and 48 hours after exposure to the stressor.Conclusion: In conclusion, voluntary, long-term exercise has been shown to elevate nociceptive thresholds, providing support for these exercise programs in the treatment of stress-induced hyperalgesia.

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Section: Traumatic Stress and Hyperalgesiacontrasting

confidence: 60%

Voluntary Chronic Exercise Decreases Nociceptive Responses Before and After a Traumatic Stressor

Mozingo

Baiamonte

Hollander

2019

JBLS

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“…At supraspinal level, the expression of microglia was increased in the prefrontal cortex of mice in a stress-induced visceral pain model [12]. Spinal microglia were found activated in various SIH paradigms, including repeated cold stress [13], water avoidance stress [15], multiple continuous stress [49], and forced swim stress [50]. In recent studies, stress was reported to sensitize the neuroinflammatory response of microglia to subsequent proinflammatory challenges [26][27][28][29][30], and this was also demonstrated to play an important role in the development of SIH.…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoid-Potentiated Spinal Microglia Activation Contributes to Preoperative Anxiety-Induced Postoperative Hyperalgesia

et al. 2016

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Clinically, preoperative anxiety adversely affected postoperative hyperalgesia. As stress-induced glucocorticoids (GCs) were reported to sensitize the activation of microglia, the present study investigated whether and how GCs and microglia played in the process of preoperative anxiety-induced postoperative hyperalgesia. The study used an animal model that exposed rats to single prolonged stress (SPS) procedure to induce preoperative anxiety-like behaviors 24 h before the plantar incisional surgery. Behavioral testing revealed that preoperative SPS enhanced the mechanical allodynia induced by plantar incision. SPS was also found to induce elevated circulating corticosterone levels, potentiate the activation of spinal microglia, and increase the expression of spinal proinflammatory cytokines. Inhibition of microglia by pretreatment with minocycline attenuated the SPS-enhanced mechanical allodynia, and this was accompanied by decreased activation of spinal microglia and expression of proinflammatory cytokines. Another experiment was conducted by administering RU486, the GC receptor (GR) antagonist, to rats. The results showed that RU486 suppressed SPS-induced and SPS-potentiated proinflammatory activation of spinal microglia and revealed analgesic effects. Together, these data indicated that inhibition of stress-induced GR activation attenuated the preoperative anxiety-induced exacerbation of postoperative pain, and the suppression of spinal microglia activation may underlie this anti-hyperalgesia effect. Pending further studies, these findings suggested that GR and spinal microglia may play important roles in the development of preoperative anxiety-induced postoperative hyperalgesia and may serve as novel targets to prevent this phenomenon.

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“…We used aquatic exercise since exercising in water decreases the compressive weight-bearing stress on the joint that is caused by land-based exercise (53). However, it is also known that exposure to repeated forced swim stress can lead to mechanical hyperalgesia and increased inflammatory and thermal nociceptive behavior in rats (54, 55). In light of this, follow-up studies could consider exposure to different types of voluntary physical activity in addition to evaluating longer time periods.…”

Section: Discussionmentioning

confidence: 99%

Impact of Physical Activity on Pain Perception in an Animal Model of Endometriosis

Hernández

Cruz

Torres-Reverón

et al. 2015

Journal of Endometriosis and Pelvic Pain Disorders

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Background Symptoms of endometriosis, such as pain and infertility, are considered significant sources of stress. In many chronic conditions, exercise can act as a stress buffer and influence pain perception. We tested the impact of swimming exercise on pain perception and pain receptors in an animal model of endometriosis. Methods Endometriosis (Endo) was induced in female rats by suturing uterine horn tissue next to the intestinal mesentery. Sham rats received sutures only. Rats were exposed to swimming exercise for 7 consecutive days, while no-exercise rats were left in the home cage. Fecal pellets were counted after swimming as an index of anxiety, and serum corticosterone levels measured. Pain perception was assessed using the hot plate test for hyperalgesia and Von Frey test for allodynia. Mu-opioid receptor (MOR) and neurokinin-1 receptor expression in the spinal cord was measured by immunofluorescence. Results Fecal pellet counts were higher in those animals that swam (p<0.05), but no significant difference in corticosterone was found. Although Endo-exercise rats had higher colonic damage (p<0.05) with more cellular infiltration, the lesions were smaller than in Endo–no exercise rats (p<0.05). Exercise did not ameliorate the hyperalgesia, whereas it improved allodynia in both groups. MOR expression was significantly higher in Endo-exercise vs. Endo–no exercise rats (p<0.01), similar to Sham–no exercise levels. Conclusions Our results point toward beneficial effects of swimming exercise during endometriosis progression. Physical interventions might be investigated further for their ability to reduce perceived stress and improve outcomes in endometriosis.

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Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia

Cited by 24 publications

References 75 publications

Voluntary Chronic Exercise Decreases Nociceptive Responses Before and After a Traumatic Stressor

Voluntary Chronic Exercise Decreases Nociceptive Responses Before and After a Traumatic Stressor

Glucocorticoid-Potentiated Spinal Microglia Activation Contributes to Preoperative Anxiety-Induced Postoperative Hyperalgesia

Impact of Physical Activity on Pain Perception in an Animal Model of Endometriosis

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