Central hepatectomy: A valuable option to avoid posthepatectomy liver insufficiency in patients requiring extensive liver resection

Abstract

Despite being uncommon, posthepatectomy liver failure (PLF) is a dreadful complication following extended hepatectomy or liver trisectionectomy. It has been reported that liver insufficiency may occur in as high as 12% of posthepatectomy patients, especially in those who have a concomitant chronic liver disease, hepatosteatosis or history of receiving long-course (>6 cycles) chemotherapy (1). Central hepatectomy or mesohepatectomy, defined as en-bloc anatomical resection of liver segments 4-5 and 8, is a valuable option in patients with central large or multiple liver lesions to minimize PLF caused by the loss of a considerable portion of functional liver parenchyma following extensive resections (2). The purpose of this video-based article is to share key procedural components to be adhered to when performing central hepatectomy.In order to render a final video reflecting our technique of central hepatectomy, we reviewed raw operation videos recorded in our surgical video collection. Every important step of the procedure was assessed visually to determine if it had been performed the same way in each case. The step was considered an integral part of our approach and reproducible if it had taken place in the majority of operations. The final video is composed of video clips demonstrating those standardized certain steps. Informed consent was obtained from all patients.All extended anatomical hepatic resections in our department are performed through a shortened modified Makuuchi incision. The right and left triangular ligaments are divided. The right and left hepatic veins are partly exposed, but not encircled with umbilical tape. Following preparation for the Pringle maneuver, parenchymal transection starts without preceding hilar dissection. The Pringle maneuver is applied intermittently (15 min occlusion and 5 min release) during transection. Parenchyme splitting is initiated just right to the falciform ligament between the left lateral (liver segments 2-3) and left medial (liver segment 4) sections, during which inflow structures of liver segment 4 arising off of the hilar plate are ligated and divided (Video). The transection on this plane is continued down to the vena cava -middle hepatic vein junction. The middle hepatic vein is secured by passing a tape around it (Video). Thereafter the attention is turned to the hilar and cystic plates again. The cystic duct is ligated and transected, and the Callot triangle is exposed. This allows for the surgeon to utilize intraparenchymal Glissonian approach when exposing the right anterior sector plate structures. The whole plate of the right anterior section is exposed en-bloc and divided by using a linear stapler (Video). This step is followed by parenchymal transection between the right anterior and posterior sections. During this transection, the split line is on the left-side of the right hepatic vein and proceeds cephalad. The resection is completed after ligation and division of the middle hepatic vein (Figure 1). It is our practice to utilize the White test ...