Central Haemodynamics and Prediction of Cardiovascular Events in Patients With Erectile Dysfunction

Vlachopoulos, Charalambos; Ioakeimidis, N.; Rokkas, K.; Angelis, A.; Terentes‐Printzios, Dimitrios; Kratiras, Z.; Georgakopoulos, Christos; Tousoulis, Dimitrios

doi:10.1093/ajh/hpw150

Cited by 13 publications

(12 citation statements)

References 32 publications

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“…Two recent studies, one of them a metaanalysis, concluded that ED is a predictor of future cardiovascular events, independently of other associated risk factors. 36,37 In this study, performed in patients with ED and subsequently diagnosed with periodontitis, we confirmed and quantified the highest occurrence of MACEs. Seven patients with both diagnoses, suffered 10 MACEs events (three patients, two events), compared to three patients with a single event each, in the other groups (no patient with two events).…”

Section: Discussionsupporting

confidence: 64%

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Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Mesa

Arrabal-Polo

Magán‐Fernández

et al. 2022

Journal of Periodontology

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Background: Periodontitis and erectile dysfunction (ED) have been linked with cardiovascular disease. The association of periodontitis and ED with the occurrence of major adverse cardiovascular events has not been previously assessed.The aim of this study was to determine if the presence of periodontitis and ED has any effect on the incidence of major adverse cardiovascular events.Methods: Male patients that attended the Urology service were enrolled in a prospective study. Erectile dysfunction was diagnosed according to the International Index of Erectile Function. Sociodemographic data and periodontal clinical parameters were gathered (pocket probing depth, clinical attachment loss, bleeding on probing (BoP), plaque index and number of teeth) at baseline. Major adverse cardiovascular events occurred both before and during the follow-up time were registered. Bivariate analyses, as well as a multivariate analysis were performed, adjusting for potential confounders. Results: A total of 158 patients were included, with a mean follow-up of 4.2 years.A greater number of major adverse cardiovascular events occurred in the group that presented periodontitis and ED (P = 0.038). After adjusting by age and previous cardiovascular disease in the multivariate analysis, the annual major adverse cardiovascular event rate was estimated to be 3.7 times higher in the same group (P = 0.049). Other periodontal clinical variables together with ED supported these results and were close to statistical significance. Conclusions: Patients with periodontitis and ED, adjusted by age and a cardiovascular disease, showed 3.7 times more risk of suffering major adverse cardiovascular events after mean follow-up of 4.2 years.

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Section: Discussionsupporting

confidence: 64%

“…These data support the hypothesis of considering ED as an early diagnosis manifestation to predict a future MACEs. Two recent studies, one of them a meta‐analysis, concluded that ED is a predictor of future cardiovascular events, independently of other associated risk factors 36,37 …”

Section: Discussionmentioning

confidence: 99%

Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Mesa

Arrabal-Polo

Magán‐Fernández

et al. 2022

Journal of Periodontology

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“…Several pathological factors that affect the blood vessels, such as atherosclerosis, endothelial dysfunction, and inflammation, can result in arteriogenic ED . In most patients with arteriogenic ED, the changes in morphology and structure caused by penile atherosclerosis reduce the filling of the cavernous body of the penis, resulting in an inability to meet the demand for blood volume during erections . Moreover, vascular endothelial dysfunction that occurs in atherosclerosis plays a pivotal role in arterial erectile dysfunction …”

Section: Introductionmentioning

confidence: 99%

Significance of blood lipid parameters as effective markers for arteriogenic erectile dysfunction

Zhang

et al. 2020

Andrology

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Objectives The aim of the study was to investigate the ability of the blood lipid parameters to predict the discrimination of arteriogenic erectile dysfunction (ED). Materials and methods 260 subjects with ED and 60 healthy controls were enrolled. Eight lipid parameters, including total cholesterol (TC), triglycerides (TG), LDL‐C, HDL‐C, non‐HDL‐C, TC/HDL ratio, TG/HDL ratio, and LDL/HDL ratio, together with other plasma biomarkers like sex hormones were measured in all participants. Nocturnal penile tumescence (NPT), penile color Doppler ultrasonography (pDUS), and neurophysiological tests were conducted in the ED group. Results Forty‐four ED patients with normal NPT, and 84 with normal vasculature or mixed vascular abnormalities were excluded. The remaining 132 men were classified into two groups, arteriogenic ED (n = 87) and venous leakage (n = 45), by pDUS. TC/HDL, LDL/HDL, and LDL‐C were significantly higher (P < .05) and HDL‐C was significantly lower (P < .05) in the arteriogenic ED group when compared with the venous and the control groups. Receiver operating characteristic curve analysis identified area under the curve values that were predictive of arteriogenic ED for: TC/HDL and LDL/HDL 0.720 and 0.737, TC/HDL ≥ 3.73 and LDL/HDL ≥ 2.01 (sensitivity: 56.3%; specificity: 83.3% vs sensitivity: 55.2%; specificity: 91.7%), HDL‐C (0.791), ≤1.25 mmol/L (sensitivity: 69%; specificity: 81.7%), LDL‐C (0.641), ≥2.41 mmol/L (sensitivity: 55.2%; specificity: 76.7%).In the arteriogenic ED group, a significant inverse correlation was detected between TC/HDL, LDL/HDL, LDL‐C and 10‐minutes peak systolic velocity (PSV) (All P < .01)and a significant positive correlation was recognized between HDL‐C and 10‐minutes PSV(P < .01). Multivariate step wise linear regression indicated lipid parameters of LDL/HDL and HDL‐C were significantly associated with 10‐MinPSV (P < .01). Conclusion These findings suggest the LDL/HDL and HDL‐C might be a powerful indicator to predict and diagnose arteriogenic ED, and lipid‐lowing therapy should be considered for these patients.

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“…In one study, it was shown that the increase in aortic vascular stiffness is significantly associated with increased severe cardiac side effects in ED patients without known cardiac disease. This study reports that PWV measurements can be used to determine cardiac risk in patients with ED (Vlachopoulos et al, ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between the severity of erectile dysfunction and aortic stiffness

et al. 2020

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Aortic stiffness increases in patients with erectile dysfunction (ED) but it is not known whether aortic stiffness affects the degree of ED. In the present study, we aimed to determine whether there is any relationship between aortic stiffness and the severity of ED. Patients with ED were divided into 3 groups according to the International Index of Erectile Function (IIEF) scores. Mild ED was named as group 1, moderate ED as group 2 and severe ED as group 3. The values of fasting blood glucose (FBG), serum lipid values, total testosterone (T. tes), and free testosterone (F tes) were recorded. Aortic stiffness was determined by pulse wave velocity (PWV) and augmentation index (AIX) measurements. The mean or median values of the laboratory parameters among the groups were similar (p > .05). No statistical difference was found between the groups in terms of AIX value (p = .386). Mean PWV values were calculated as 7.26, 8.30 and 8.78 in group 1, group 2 and group 3 respectively. PWV values were significantly different between groups (p < .0001). PWV values were found to be increased with increasing severity of erectile dysfunction.

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Central Haemodynamics and Prediction of Cardiovascular Events in Patients With Erectile Dysfunction

Cited by 13 publications

References 32 publications

Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Significance of blood lipid parameters as effective markers for arteriogenic erectile dysfunction

The relationship between the severity of erectile dysfunction and aortic stiffness

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