Central H1 and H2 receptor participation in the control of water and salt intake in rats

Magrani, Janeide; Silva, Emilio de Castro e; Ramos, Ana; Athanazio, Rodrigo Abensur; Barbetta, Marcelo Campos; Fregoneze, J.B.

doi:10.1016/j.physbeh.2004.11.010

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…Administration of histamine into the lateral hypothalamus increases water intake in water-satiated rats [ 26 ]. Histamine H1 or H2 receptor antagonists microinjected into the ventromedial hypothalamic nucleus reduce water intake [ 27 ], while their administration into the ventricles has no effect [ 28 ]. However, lesions restricted to either of TMN subdivisions E1-E4 induce a persistent polydipsia [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine

et al. 2016

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The histaminergic system is one component of the ascending arousal system which is involved in wakefulness, neuroendocrine control, cognition, psychiatric disorders and motivation. During the appetitive phase of motivated behaviors the arousal state rises to an optimal level, thus giving proper intensity to the behavior. Previous studies have demonstrated that the histaminergic neurons show an earlier activation during the appetitive phase of feeding, compared to other ascending arousal system nuclei, paralleled with a high increase in arousal state. Lesions restricted to the histaminergic neurons in rats reduced their motivation to get food even after 24h of food deprivation, compared with intact or sham lesioned rats. Taken together, these findings indicate that the histaminergic system is important for appetitive behavior related to feeding. However, its role in other goal-directed behaviors remains unexplored. In the present work, male rats rendered motivated to obtain water, sex, or amphetamine showed an increase in Fos-ir of histaminergic neurons in appetitive behaviors directed to get those reinforcers. However, during appetitive tests to obtain sex, or drug in amphetamine-conditioned rats, Fos expression increased in most other ascending arousal system nuclei, including the orexin neurons in the lateral hypothalamus, dorsal raphe, locus coeruleus and laterodorsal tegmental neurons, but not in the ventral tegmental area, which showed no Fos-ir increase in any of the 3 conditions. Importantly, all these appetitive behaviors were drastically reduced after histaminergic cell-specific lesion, suggesting a critical contribution of histamine on the intensity component of several appetitive behaviors.

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Section: Discussionmentioning

confidence: 99%

The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine

et al. 2016

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“…Thirst and salt appetite are important behaviors that help mammals to regulate plasma osmolarity, blood volume and blood pressure [1,2]. Thirst, which provides the motivation to drink, is an important component of the coordinated sequence of physiological responses that maintain the volume and composition of body fluids [3].…”

Section: Introductionmentioning

confidence: 99%

“…The homeostatic regulation of fluid intake by the brain is multifactorial: Osmotic, ionic, hormonal, and nervous signals converge on, and are integrated within, the central nervous system [3]. Specialized structures located both in the central nervous system and in strategic peripheral sites detect changes in these parameters continuously and accurately [2]. There is evidence that some osmoreceptors and osmoreceptive neurons are situated in the preoptic/hypothalamic region of the brain, rostral tissue in the anterior wall of the third ventricle (AV3V) [4], fourth and lateral ventricles [5], dorsal part of the organum vasculosum of the lamina terminalis (OVLT), the periphery of the sufornical organ (SFO) [3], median preoptic nucleus (MnPO) [4], lateral hypothalamic area and the hypothalamic paraventricular nucleus [3,6].…”

Section: Introductionmentioning

confidence: 99%

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Interaction between Dopaminergic and Angiotensinergic Systems on Thirst in Adult Male Rats

Sharifkhodaei¹,

Naghdi²,

Oryan³

2012

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Thirst, which provides the motivation to drink, is an important component of the coordinated sequence of physiological responses that maintain the volume and composition of body fluids. Special structures in the central nervous system like periventricular organs detect changes in these parameters continuously. The present study investigated the interaction between dopaminergic and angiotensinergic systems on water intake in adult male rats. Intracerebroventricular (ICV) injections were carried out in all experiments after 24 h deprivation of water intake. After the deprivation interval, the volume of consumed water was measured for 1 h. Administration the angiotensinergic (AT 1 ) receptor antagonist Losartan (45 µg/rat), and the dopaminergic antagonist Chlorpromazine (40 µg/rat) significantly decreased water intake when compared to saline-treated controls. In contrast, ICV microinjection of the dopaminergic agonist Bromocriptine (10 µg/rat) significantly increased water intake when compared to saline-treated controls. ICV injection of Bromocriptine 15 min after Losartan administration was able to attenuate the inhibitory effect of Losartan on water intake, whereas administration of Chlorpromazine 15 min after Losartan was unable to change the Losartan effect. These results suggest that the dopaminergic system interactions with the angiotensinergic system to regulate water intake through circumventricular organs. Dopaminergic and angiotensinergic neurons can monitor and regulate water intake via the stimulatory and inhibitory effects on each other, respectively.

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Hyperphagia and increased body weight induced by lesions of the ventral tuberomammillary system

Mahía

Bernal

Puerto

2007

Behavioural Brain Research

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Central H1 and H2 receptor participation in the control of water and salt intake in rats

Cited by 8 publications

References 34 publications

The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine

The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine

Interaction between Dopaminergic and Angiotensinergic Systems on Thirst in Adult Male Rats

Hyperphagia and increased body weight induced by lesions of the ventral tuberomammillary system

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