Central Giant Cell Lesion

Valentine, James; Nelson, Brenda L.

doi:10.1007/s12105-011-0297-4

Cited by 19 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some authors concluded that the giant cell tumor and CGCL represent different spectra of a single pathological process (25) . Conversely, some authors claim that CGCL actually constitute a benign tumor (37) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…This lesion affects patients aged 2 to 80 years, although most cases are below 30 years of age. The female gender is the most affected, possibly due to hormonal factors (pregnancy and estrogen) despite the fact that the lesions rarely express estrogen receptors (26,30,37) . CGCL are more common in the anterior portion of the mandible and often cross the midline (6-8, 22, 25, 27, 30) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…Moreover, displacement of teeth, root resorption and perforation of the cortical bone may be observed (2,6,22,24,25,36,37) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…The latter lesions cause pain and exhibit rapid growth, usually larger than five centimeters, producing expansion and perforation of the cortical bone, displacement of teeth and root resorption. Besides, there is a high recurrence rate, which generally ranges between 37.5% and 70% (7,8,14,15,25,26,29,30,32,37) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…number of multinucleated giant cells containing 4 to 20 nuclei (aggregated or not) dispersed in the fibrous stroma in a perivascular or adjacent position to areas of hemorrhage (Figures 3 and 4). Round macrophages, deposition of hemosiderin, extravasated erythrocytes, foci of osteoid material (bone trabeculae), dystrophic calcification and predominantly mononuclear inflammatory infiltrate, particularly surrounding the periphery of the lesion, are also found (2,6,8,14,19,22,25,28,36,37) . Although multinucleated giant cells are present in large quantity, they are not regarded as proliferative cells.…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

See 4 more Smart Citations

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

Introduction and objective: The peripheral and central giant cell lesions (PGCL and CGCL) are a group of pathological entities with similar histopathological features and whose origin has not been fully elucidated. The former is reactive and the latter exhibits a nonneoplastic proliferative behavior. This article aims to review the literature on peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) by discussing the most important aspects pertaining to each of them. Results: These lesions are found in different locations and show diverse clinical signs despite having the same histopathological features. The treatment consists in the surgical resection by different techniques depending on the type of the lesion and clinical conditions. In the case of CGCL, drug therapy may also be employed. Conclusion: Although there is no consensus in the literature, it is essential to know the etiology of these lesions as well as the exact origin of the giant cells. Due to their singular biological behavior, it is of utmost importance to establish a differential diagnosis between the two lesions and other processes that have similar clinical, radiological and histological characteristics, inasmuch as this procedure is essential to provide a suitable treatment and establish a prognosis.

show abstract

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…Moreover, displacement of teeth, root resorption and perforation of the cortical bone may be observed (2,6,22,24,25,36,37) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

show abstract

Role of osteoclasts in oral homeostasis and jawbone diseases

Omi

Mishina

2020

Oral Science International

View full text Add to dashboard Cite

The jawbone is a unique structure as it serves multiple functions in mastication. Given the fact that the jawbone is remodeled faster than other skeletal bones, bone cells in the jawbone may respond differently to local and systemic cues to regulate bone remodeling and adaptation. Osteoclasts are bone cells responsible for removing old bone, playing an essential role in bone remodeling. Although bone resorption by osteoclasts is required for dental tissue development, homeostasis and repair, excessive osteoclast activity is associated with oral skeletal diseases such as periodontitis. In addition, antiresorptive medications used to prevent bone homeostasis of tumors can cause osteonecrosis of the jaws that is a major concern to the dentist. Therefore, understanding of the role of osteoclasts in oral homeostasis under physiological and pathological conditions leads to better targeted therapeutic options for skeletal diseases to maintain patients' oral health. Here, we highlight the unique features of the jawbone compared to the long bone and the involvement of osteoclasts in the jawbone-specific diseases.

show abstract