Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner

Hyland, Lindsay; Rosenbaum, S.D.; Edwards, Alexander D.; Palacios, Daniel; Graham, M. Dean; Pfaus, James G.; Woodside, Barbara; Abizaid, Alfonso

doi:10.1016/j.yhbeh.2017.10.012

Cited by 18 publications

(12 citation statements)

References 71 publications

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“…Central ghrelin receptor stimulation modulates sex motivation in male rats in a site-dependent manner. Within the VTA, ghrelin may act to enhance sex motivation, while acting on the medial preoptic area (mPOA) to decrease sex motivation and promote foraging [264]. Another study on mice showed that genetic suppression of the GHSR1a in male mice attenuates the preference for female mice, sexual motivation, and interaction, by effects on DA neurotransmission [72].…”

Section: Effect Of Ghrelin On Sexualmentioning

confidence: 99%

Physiological Effect of Ghrelin on Body Systems

Akalu

Molla

Dessie

et al. 2020

International Journal of Endocrinology

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Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of physiological effects. In this review, we found/confirmed that ghrelin has effect on all body systems. It induces appetite; promotes the use of carbohydrates as a source of fuel while sparing fat; inhibits lipid oxidation and promotes lipogenesis; stimulates the gastric acid secretion and motility; improves cardiac performance; decreases blood pressure; and protects the kidneys, heart, and brain. Ghrelin is important for learning, memory, cognition, reward, sleep, taste sensation, olfaction, and sniffing. It has sympatholytic, analgesic, antimicrobial, antifibrotic, and osteogenic effects. Moreover, ghrelin makes the skeletal muscle more excitable and stimulates its regeneration following injury; delays puberty; promotes fetal lung development; decreases thyroid hormone and testosterone; stimulates release of growth hormone, prolactin, glucagon, adrenocorticotropic hormone, cortisol, vasopressin, and oxytocin; inhibits insulin release; and promotes wound healing. Ghrelin protects the body by different mechanisms including inhibition of unwanted inflammation and induction of autophagy. Having a clear understanding of the ghrelin effect in each system has therapeutic implications. Future studies are necessary to elucidate the molecular mechanisms of ghrelin actions as well as its application as a GHSR agonist to treat most common diseases in each system without any paradoxical outcomes on the other systems.

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Section: Effect Of Ghrelin On Sexualmentioning

confidence: 99%

Physiological Effect of Ghrelin on Body Systems

Akalu

Molla

Dessie

et al. 2020

International Journal of Endocrinology

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“…Much of the focus on the orexigenic effects of ghrelin has been on GHSR within the arcuate nucleus 22–27 but these receptors are expressed in other hypothalamic nuclei implicated in the control of food intake such as the paraventricular nucleus (PVN), the dorsomedial hypothalamus (DMH), and ventromedial hypothalamus (VMH) 28,29 . The GHSR is also expressed in extrahypothalamic areas including the ventral tegmental area (VTA), 28,29 where ghrelin stimulates a rapid increase in food intake and increases the appetitive aspects of male sexual behaviour 30–34 . Within the hippocampus (HPC) GHSR signalling is associated with multiple functions including increasing food intake and facilitating social learning of food preferences 35,36 …”

Section: Introductionmentioning

confidence: 99%

“…28,29 The GHSR is also expressed in extrahypothalamic areas including the ventral tegmental area (VTA), 28,29 where ghrelin stimulates a rapid increase in food intake and increases the appetitive aspects of male sexual behaviour. [30][31][32][33][34] Within the hippocampus (HPC) GHSR signalling is associated with multiple functions including increasing food intake and facilitating social learning of food preferences. 35,36 Thus, in the present study we investigated whether the increased GHSR expression previously observed within whole hypothalami of lactating rats 20 would also be seen in more discrete hypothalamic and extrahypothalamic areas including the mediobasal hypothalamus, VTA and HPC.…”

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confidence: 99%

Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin

Wellman

Budin

Woodside

et al. 2022

J Neuroendocrinology

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Lactating rats show changes in the secretion of hormones and brain signals that promote hyperphagia and facilitate the production of milk. Little is known, however, about the role of ghrelin in the mechanisms sustaining lactational hyperphagia. Here, we used Wistar female rats that underwent surgery to sever the galactophores to prevent milk delivery (GC rats) and decrease the energetic drain of milk delivery. We compared plasma acyl-ghrelin concentrations and growth hormone secretagogue receptor (GHSR) mRNA expression in different brain regions of GC rats with those of sham operated lactating and nonlactating rats. Additional lactating and nonlactating rats were implanted with cannulae aimed at the lateral ventricles and were used to compare feeding responses to central ghrelin or GHSR antagonist infusions to those of nonlactating rats receiving similar infusions on day 14-16 postpartum (pp). Resultsshow lower plasma acyl-ghrelin concentrations on day 15 pp sham operated lactating rats compared to GC or nonlactating rats. These changes occur in association with increased GHSR mRNA expression in the hypothalamic arcuate nucleus (ARC) and ventral tegmental area (VTA) of sham operated lactating rats. Despite lactational hyperphagia, infusions of ghrelin (0.25 or 1 μg) resulted in similar increases in food intake in lactating and nonlactating rats. In addition, infusions of the GHSR antagonist JMV3002 (4 μg in 1 μl of vehicle) produced greater suppression of food intake in lactating rats than in nonlactating rats. These data suggest that, despite lower plasma ghrelin, the energetic drain of lactation increases sensitivity to the orexigenic effects of ghrelin in brain regions important for food intake and energy balance, and these events are associated with lactational hyperphagia.

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“…Interestingly, both CSDS and chronic unpredictable stress increase circulating ghrelin levels, and ghrelin receptor knockout mice are protected from the stress-induced metabolic responses in either model, despite diverging (model-dependent) metabolic outcomes (Patterson et al, 2010, 2013a). The effects of ghrelin receptor ablation across stress models may be attributed to the activation of ghrelin receptors in different brain regions, a phenomenon that is responsible for the diverging effects of ghrelin on sexual motivation (Hyland et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Stress and glucocorticoid modulation of feeding and metabolism

Balsevich

Abizaid

Chen

et al. 2019

Neurobiology of Stress

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This perspective highlights research presented as part of the symposium entitled, “Stress and Glucocorticoid Modulation of Feeding and Metabolism” at the 2018 Neurobiology of Stress Workshop held in Banff, AB, Canada. The symposium comprised five researchers at different career stages who each study different aspects of the interaction between the stress response and metabolic control. Their collective results reveal the complexity of this relationship in terms of behavioural and physiological outcomes. Their work emphasizes the need to consider the level of interaction (cellular, tissue, systems) as well as the timing and context in which the interaction is studied. Rather than a comprehensive review on the work presented at the Symposium, here we discuss recurring themes that emerged at the biennial workshop, which address new avenues of research that will drive the field forward.

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Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner

Cited by 18 publications

References 71 publications

Physiological Effect of Ghrelin on Body Systems

Physiological Effect of Ghrelin on Body Systems

Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin

Stress and glucocorticoid modulation of feeding and metabolism

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