“…74,75 However, an experimental study that utilized short-term low-dose estradiol administered intracerebroventricularly in a male mouse model of diet-induced obesity was associated with a reduction in food intake, body weight, and visceral adiposity. 76 Similarly, in TW, flow-mediated vasodilation was similar compared with cis-women but higher compared with cis-men. 77 In contrast, estradiol administration for 5 days in a male rat (model of TW) was associated with a reduction in vascular function in aortic rings.…”