Central effects of opioidergic system on food intake in birds and mammals: a review

Mahdavi, Kimia; Zendehdel, Morteza; Baghbanzadeh, Ali

doi:10.1007/s11259-023-10142-w

Cited by 7 publications

(2 citation statements)

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“…Several lines of evidence have shown that neuropeptides and neurotransmitters in the CNS could affect animal food intake and pain sensation (47)(48)(49)(50)(51)(52). Wingless (Wnt) signaling is a key pathway that regulates glycogen synthase kinase 3β (GSK3β) activity (53).…”

Section: Discussionmentioning

confidence: 99%

Creatine Activity as a Neuromodulator in the Central Nervous System

2023

ARI

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Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated that similar to neurotransmitters, creatine is released in an excitotoxic and action potential-dependent manner and acts as a neuromodulator. Creatine deficiency syndromes are characterized by severe mental and developmental disorders. Studies have reported that brain creatine content could be enhanced with creatine supplementation. Nevertheless, there is still limited knowledge about the effects of creatine on the central nervous system. However, ample evidence has proved the neuroprotective effects of creatine on various mental aspects, such as cognition, memory skills, and spatial memory. The present review aimed to review available experimental data and clinical observations confirming creatine roles in the central transmission process. A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, and Google Scholar database using all available MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, and Neuroprotection. Electronic database searches were combined and duplicates were removed. Here, first, creatine and its potential influence on cognitive health and performance were briefly reviewed. Next, the existing experimental and clinical evidence was specifically explored to understand how creatine could interact as a neurotransmitter in the nervous system. Studies have revealed that exogenous creatine supplementation decreases neuronal cell loss in experimental paradigms of neurological diseases. It was observed that creatine could interact with the N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA receptor, serotonin 1A receptors, and presumably α1-adrenoceptor and play critical roles in the central transmission process which implies that creatine can be considered a neuromodulator.

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Section: Discussionmentioning

confidence: 99%

Creatine Activity as a Neuromodulator in the Central Nervous System

2023

ARI

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“…Various nuclei of the hypothalamus involved in the central regulation of food intake include the arcuate nucleus (ARC) , ventromedial hypothalamus (VMH) (Yousefvand et al, 2021), lateral hypothalamus area (LHA) (Yousefvand et al, 2022), paraventricular nucleus (PVN) , and Dorsomedial Nucleus (DMN) (Yousefvand et al, 2023). In general, a combination of environmental endocrine and neuron signals that re ect the animal's energy status regulate feeding (Mahdavi et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

The effect of glycyrrhizin on central regulation of food intake in broilers injected with LPS

Rahdari,

Hamidi

2023

Preprint

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Poultry farming poses challenges due to hygiene and nutrition issues, leading to disease and inflammation in chickens. One of the challenges is gram-negative bacteria that stimulate pro-inflammatory reactions through lipopolysaccharide (LPS) and cause disease and anorexia. Licorice, a medicinal plant with glycyrrhizin (Gly) as its main active ingredient, was used in our experiment to investigate the effects of glycyrrhizin on food intake in LPS-injected broilers. Accordingly, the study involved three experiments involving 72 male broiler chickens, to examine the impact of Gly. on their food intake in LPS-injected broilers (n = 24). Experiment 1 was conducted to examine the effects of IP injection of Gly. (12.5, 25, and 50 mg) on food intake in chickens. In experiment 2, the birds received intracerebroventricular (ICV) injections of LPS (6.25, 12.5, and 25 ng). In the last experiment, we investigated the impact of IP injection of glycyrrhizin on inflammation induced by LPS. Based on the findings, IP injection of glycyrrhizin significantly increased food intake in a dose-dependent manner (p < 0.05). Whereas, LPS significantly reduced food intake in food-deprived chickens. Gly. can neutralizes reduced food intake caused by inflammation in broilers, highlighting its potential role in modulating food intake in broilers.

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