Central effects of acetylcholine

Herman, Zbigniew S.; Kmieciak-Kołada, K; J, Słomińska-Zurek; Szkilnik, Ryszard

doi:10.1007/bf00422802

Cited by 13 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ACh decreased locomotor and exploratory activity in mice in a, similar manner to that previously described (Herman et al, 1972). These effects may be of muscarinic nature since they were abolished by atropine.…”

Section: Resultssupporting

confidence: 69%

Behavioural Changes Induced in Conscious Mice by Intracerebroventricular Injection of Catecholamines, Acetylcholine and 5‐hydroxytryptamine

Herman

1975

British J Pharmacology

View full text Add to dashboard Cite

A simple method of injecting soluble substances into the lateral ventricle of the brain of the conscious mouse is described. 2 The effect of various doses of noradrenaline, dopamine, acetylcholine, 5-hydroxytryptamine given into the right lateral brain ventricle were tested on locomotor and exploratory activities of mice. 3 Noradrenaline in a dose of 0.1 mg increased locomotor activity. This effect was prevented by phenoxybenzamine but not by propranolol. 4 Higher doses of noradrenaline (1 or 10 Mg) decreased locomotor and exploratory activities. Propranolol but not phenoxybenzamine abolished these effects. 8 Acetylcholine (1 and 10 Mg) and 5-hydroxytryptamine (1 Mg) inhibited locomotor and exploratory activity. 9 The effects of 1 and 10 Mg of acetylcholine were abolished by atropine (5 mg/kg i.p.).Methysergide (5 mg/kg i.p.) had no influence on the effects of 5-hydroxytryptamine (1 Mg).

show abstract

Section: Resultssupporting

confidence: 69%

Behavioural Changes Induced in Conscious Mice by Intracerebroventricular Injection of Catecholamines, Acetylcholine and 5‐hydroxytryptamine

Herman

1975

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…havioral responses. Nevertheless, the initial rise in both ACh and 5-HT levels correlates with the observed decrease in locomotor activity (Herman et al, 1972;Green et al, 1975;Warbritton et al, 1978). Although analyses of specific brain parts were not performed, the initial increase in ACh and 5-HT levels presumably occurs predominantly in the left hemisphere into which DHBT was administered.…”

Section: Discussionmentioning

confidence: 97%

5,5′‐Dihydroxy‐4,4′‐Bitryptamine: A Potentially Aberrant, Neurotoxic Metabolite of Serotonin

Wrona

Goyal

Turk

et al. 1992

Journal of Neurochemistry

View full text Add to dashboard Cite

Previous investigators have detected unknown oxidized forms of 5-hydroxytryptamine (5-HT) in the CSF of Alzheimer's disease (AD) patients. Furthermore, an unidentified autoxidation product of this neurotransmitter is an inhibitor of acetylcholinesterase (AChE), an enzyme compromised in the Alzheimer brain. In this study it is demonstrated that the major product of autoxidation of 5-HT is 5,5'-dihydroxy-4,4'-bitryptamine (DHBT). Central administration of DHBT to mice at a dose of 40 micrograms (free base) evokes profound behavioral responses, which persist until the animals die (approximately 24 h). One hour after central administration of DHBT, the levels of norepinephrine, dopamine, 5-HT, and acetylcholine and their metabolites in whole brain are greatly elevated. Disturbances to the catecholaminergic and serotonergic systems were still evident shortly before the death of animals. DHBT is also shown to be a noncompetitive inhibitor of AChE in vitro. These observations suggest that if DHBT is formed as an aberrant metabolite of 5-HT in the human brain, it could potentially be neurotoxic and contribute to the neuronal degeneration and other neurochemical and neurobiochemical changes associated with AD or perhaps other neurodegenerative diseases.

show abstract

“…Similarly, several investigators have reported that anticholinergics antagonize increases in homovanillic acid induced by neuroleptics (Anden, 1972;Bowers & Roth, 1972;O'Keefe, Sharman, & Vogt, 1970) and also induced modification of dopamine turnover (Anden & Bedard, 1971;Corrodi, Fuxe, & Lidbrink, 1972). Finally, Herman, Kmieciak-Kolada, Slominska-Zurek, and Szkilnik (1972) observed that intravenous injection of ACh decreased levels of norepinephrine in cortex, mesencephalon, pons, and medulla, while Kazic (1973) reported that intravenous administration of physostigmine markedly increased synthesis and turnover of norepinephrine in the hypothalamus. Taken together, these data indicate that modification of either acetylcholine or dopamine, inter alia, will also result in a change in transmitter level in the complementary system.…”

Section: Balance and Reciprocal Innervation Of Neurotransmittersmentioning

confidence: 93%

Time-dependent variations in aversively motivated behaviors: Nonassociative effects of cholinergic and catecholaminergic activity.

Anisman¹

1975

Psychological Review

146

View full text Add to dashboard Cite

The role of acetylcholine and central catecholamines in modulating aversively motivated behaviors, and behavior following exposure to uncontrollable stressors, is evaluated. It is suggested that in the presence of adequate associative processes, nonassociative factors, mediated by stress-induced neurochemical changes, determine avoidance response rate. Moreover, in addition to the existence of a balanced state between excitatory catecholamine and inhibitory Cholinergic systems, it is posited that these neurochemical systems may be mutually regulatory. Excessive stimulation of one system may induce a compensatory antagonistic rebound in the complementary system, thereby maintaining neurochemical homeostasis. Owing to timedependent variations in neurotransmitter activity, temporal variations in performance may occur following initial exposure to aversive stimulation. Alterations in neurochemical activity that affect nonassociative processes have predictable effects on time-dependent variations in avoidance performance. The model is extended to deal with other stress related phenomena, for example, helplessness, depression, and ulceration.

show abstract

Central effects of acetylcholine

Cited by 13 publications

References 12 publications

Behavioural Changes Induced in Conscious Mice by Intracerebroventricular Injection of Catecholamines, Acetylcholine and 5‐hydroxytryptamine

Behavioural Changes Induced in Conscious Mice by Intracerebroventricular Injection of Catecholamines, Acetylcholine and 5‐hydroxytryptamine

5,5′‐Dihydroxy‐4,4′‐Bitryptamine: A Potentially Aberrant, Neurotoxic Metabolite of Serotonin

Time-dependent variations in aversively motivated behaviors: Nonassociative effects of cholinergic and catecholaminergic activity.

Contact Info

Product

Resources

About