Central CRF and acute stress differentially modulate probabilistic reversal learning in male and female rats

Bryce, Courtney A.; Floresco, Stan B.

doi:10.1016/j.bbr.2020.112929

Cited by 10 publications

(4 citation statements)

References 88 publications

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“…However, even though stress increased these measures, it did not have a disproportionately greater effect in females. These impairments are in keeping with previous work showing that restraint stress (or increased CRF activity) generally slows reward-related decision latencies, irrespective of whether these stressors alter the direction of choice on different forms of cost/benefit decision making ( Bryce et al, 2020 ; Bryce and Floresco, 2016 , 2021 ; Shafiei et al, 2012 ).…”

Section: Discussionsupporting

confidence: 90%

Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment

Laino Chiavegatti,

Floresco

2024

Neurobiology of Stress

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Section: Discussionsupporting

confidence: 90%

Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment

Laino Chiavegatti,

Floresco

2024

Neurobiology of Stress

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“…Therefore, a floor effect existed in the females where it was difficult to see decreased lever pressing from a low baseline in both an outcome devaluation task and with Gq-DREADD mediated activation of CRF+ aBNST neurons in concurrent choice. Sex differences have been observed previously in appetitive learning and lever pressing tasks, where females are less engaged compared to males [51][52][53][54]. Future experiments are needed to determine the cause of these sex differences in lever pressing.…”

Section: Discussionmentioning

confidence: 80%

Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors

Maita

Bazer

Chae

et al. 2023

Preprint

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Corticotropin-releasing factor (CRF) in the anterior bed nucleus of the stria terminalis (aBNST) is associated with chronic stress and avoidance behavior. However, CRF+ BNST neurons project to reward- and motivation-related brain regions, suggesting a potential role in motivated behavior. We used chemogenetics to selectively activate CRF+ aBNST neurons in male and female CRF-ires-Cre mice during an effort-related choice task and a concurrent choice task. In both tasks, mice were given the option either to exert effort for high value rewards or to choose freely available low value rewards. Acute chemogenetic activation of CRF+ aBNST neurons reduced barrier climbing for a high value reward in the effort-related choice task in both males and females. Furthermore, acute activation of CRF+ aBNST neurons also reduced effortful lever pressing in high-performing males in the concurrent choice task. These data suggest a novel role for CRF+ aBNST neurons in effort-based decision and motivated behavior.

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“…The studies by Bryce and Floresco [105] and Dieterich [106] revealed the role of stress hormones in sensitivity to feedback. In the former, increased corticotropin releasing factor (CRF) signaling reduced negative feedback sensitivity in rats, while in the latter, chronic corticosterone administration decreased the sensitivity of mice to positive feedback, which has been interpreted as a robust blunting of positive processing [106].…”

Section: Biased Sensitivity To Feedbackmentioning

confidence: 99%

Neuromolecular Underpinnings of Negative Cognitive Bias in Depression

Noworyta-Sokołowska

Cieślik

Ryguła

2021

Cells

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This selective review aims to summarize the recent advances in understanding the neuromolecular underpinnings of biased cognition in depressive disorder. We begin by considering the cognitive correlates of depressed mood and the key brain systems implicated in its development. We then review the core findings across two domains of biased cognitive function in depression: pessimistic judgment bias and abnormal response to negative feedback. In considering their underlying substrates, we focus on the neurochemical mechanisms identified by genetic, molecular and pharmacological challenge studies. We conclude by discussing experimental approaches to the treatment of depression, which are derived largely from an improved understanding of its cognitive substrates.

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Central CRF and acute stress differentially modulate probabilistic reversal learning in male and female rats

Cited by 10 publications

References 88 publications

Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment

Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment

Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors

Neuromolecular Underpinnings of Negative Cognitive Bias in Depression

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