Central Cortico-Subcortical Involvement

Rademakers, R; Knaap, Marjo S. van der; Verbeeten, B.; Barth, P. G.; Valk, Jacob

doi:10.1097/00004728-199503000-00017

Cited by 34 publications

(3 citation statements)

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“…The lack of convincing evidence for sex-specific anxious and exploratory behaviors may stem from the scarcity of sex-comparative research controlling for HI methods, animal age, and brain injury severity (Netto et al, 2017 ). Our MRI results are consistent with those of Gadian et al, suggesting that the hip and str can be affected by HI (Rademakers et al, 1995 ; Toft, 1999 ; Almli et al, 2000 ; Gadian et al, 2000 ; Wagner et al, 2002 ; Mañeru et al, 2003 ). These structures have been linked to certain cognitive functions including attention and memory, and they are hypothesized to play a role in the pathogenesis of schizophrenia, attention deficit and hyperactivity disorder, and autism (DeLong, 1992 ; Lou, 1996 ; Simon, 1999 ; Dilenge et al, 2001 ; De Haan et al, 2006 ).…”

Section: Discussionsupporting

confidence: 92%

MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging

Bao,

Zhang,

Zhao

2023

Front. Neurosci.

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ObjectiveHypoxic-ischemic encephalopathy can lead to lifelong morbidity and premature death in full-term newborns. Here, we aimed to determine the efficacy of diffusion kurtosis (DK) [mean kurtosis (MK)] and diffusion tensor (DT) [fractional anisotropy (FA), mean diffusion (MD), axial diffusion (AD), and radial diffusion (RD)] parameters for the early diagnosis of early brain histopathological changes and the prediction of neurodegenerative events in a full-term neonatal hypoxic-ischemic brain injury (HIBD) rat model.MethodsThe HIBD model was generated in postnatal day 7 Sprague-Dawley rats to assess the changes in DK and DT parameters in 10 specific brain structural regions involving the gray matter, white matter, and limbic system during acute (12 h) and subacute (3 d and 5 d) phases after hypoxic ischemia (HI), which were validated against histology. Sensory and cognitive parameters were assessed by the open field, novel object recognition, elevated plus maze, and CatWalk tests.ResultsRepeated-measures ANOVA revealed that specific brain structures showed similar trends to the lesion, and the temporal pattern of MK was substantially more varied than DT parameters, particularly in the deep gray matter. The change rate of MK in the acute phase (12 h) was significantly higher than that of DT parameters. We noted a delayed pseudo-normalization for MK. Additionally, MD, AD, and RD showed more pronounced differences between males and females after HI compared to MK, which was confirmed in behavioral tests. HI females exhibited anxiolytic hyperactivity-like baseline behavior, while the memory ability of HI males was affected in the novel object recognition test. CatWalk assessments revealed chronic deficits in limb gait parameters, particularly the left front paw and right hind paw, as well as poorer performance in HI males than HI females.ConclusionsOur results suggested that DK and DT parameters were complementary in the immature brain and provided great value in assessing early tissue microstructural changes and predicting long-term neurobehavioral deficits, highlighting their ability to detect both acute and long-term changes. Thus, the various diffusion coefficient parameters estimated by the DKI model are powerful tools for early HIBD diagnosis and prognosis assessment, thus providing an experimental and theoretical basis for clinical treatment.

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Section: Discussionsupporting

confidence: 92%

MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging

Bao,

Zhang,

Zhao

2023

Front. Neurosci.

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“…If new-born is unable to breathe spontaneously at birth it results birth asphyxia [10] and causes a damaging condition of impaired blood gas exchange and if it persists leading to progressive hypoxemia, hypercapnia with significant metabolic acidosis and tissue oxygen debt, which can cause serious multi organ failure and poor prognosis and high mortality stillbirth or lifelong disability in the surviving infant [13][14][15][16][17][18][19] commonly with a very high incidence of 25% irreversible neurologic damage [8,[20][21][22][23][24][25]] and 1.15 million develop clinical encephalopathy [26][27][28] such as cerebral palsy, mental retardation and epilepsy leading to detrimental long term consequences for both child and family [29,30]. Cognitive and behavioural difficulties [18,19] which leads to memory and attention deficit hyperactivity disorder (ADHD), autism and schizophrenia [31,32].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Birth Asphyxia and Associated Factors among Neonates Delivered in Dilchora Referral Hospital, in Dire Dawa, Eastern Ethiopia

Ibrahim¹,

Seid²,

Abdulie³

2017

Clinics Mother Child Health

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Introduction: The greatest gap in new-born care is often during the critical first week of life when most neonatal and maternal deaths often occur at home and without any contact with the formal health sector. Some unacceptable practices such as unskilled attendants during delivery, unhygienic delivery practices, taboos and superstitions associated with caring for the new-born greatly affect new-born survival in Ethiopia.

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“…Cognitive and behavioral difficulties can also be expected because of the patterns of brain injury that have been associated with neonatal encephalopathy. The hippocampus and striatum are among the brain structures that can be affected [14]- [18]. These structures have been associated with specific cognitive functions such as memory and attention and hypothesized to play a role in the pathogenesis of attention deficit hyperactivity disorder (ADHD), autism and schizophrenia [19]- [23].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Birth Asphyxia in Rural District Matiari, Pakistan: A Case Control Study

Tabassum¹,

Rizvi²,

Ariff³

et al. 2014

IJCM

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Background: During the past two decades there has been a sustained decline in child mortality; however, neonatal mortality has remained stagnant. Each year approximately 4 million babies are born asphyxiated resulting in 2 million neonatal deaths and intrapartum stillbirths. Almost all neonatal deaths occur in developing countries, where the majority is delivered at homes with negligible antenatal care and poor perinatal services. Objectives: To identify socio-demographic and clinical risk factors associated with birth asphyxia in Matiari District of Sindh Province, Pakistan. Method: A matched case control study was conducted in Matiari District with 246 cases and 492 controls. Newborn deaths with birth asphyxia diagnosed through verbal autopsy accreditation during 2005 and 2006 were taken as cases. Controls were the live births during the same period, matched on area of residence, gender and age. Result: The factors found to be associated with birth asphyxia mortality in Matiari District of Sindh Province, Pakistan are maternal education, history of stillbirths, pregnancy complications (including smelly or excessive vaginal discharge and anemia), intrapartum complications (including fever, prolong or difficult labour, breech delivery, cord around child's neck, premature delivery, large baby size) and failure to establish spontaneous respiration after birth. Conclusion and Recommendation: There is an immediate need to develop strategies for early identification and management of factors associated with birth asphyxia by involving women, families, communities, community health workers, health professionals and policy makers. Community health workers should be trained for emergency obstetric care, basic newborn care including preliminary resuscitation measures to provide skilled birth attendance and encourage early recognition and referral.

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Central Cortico-Subcortical Involvement

Cited by 34 publications

References 0 publications

MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging

MR imaging and outcome in neonatal HIBD models are correlated with sex: the value of diffusion tensor MR imaging and diffusion kurtosis MR imaging

Prevalence of Birth Asphyxia and Associated Factors among Neonates Delivered in Dilchora Referral Hospital, in Dire Dawa, Eastern Ethiopia

Risk Factors Associated with Birth Asphyxia in Rural District Matiari, Pakistan: A Case Control Study

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