Central corneal thickness and its determinants in a geriatric population: a population-based study

Hashemi, Hassan; Nabovati, Payam; Aghamirsalim, Mohamadreza; Yekta, Abbasali; Rezvan, Farhad; Khabazkhoob, Mehdi

doi:10.1038/s41433-022-01946-2

Cited by 6 publications

(3 citation statements)

References 64 publications

(79 reference statements)

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“…We also demonstrated a negative correlation of CC and CCT, and similar results were also reported in previous studies with young subjects 12 , 26 . However, the correlation of CC and CCT may be positive in the elderly 27 , 28 . CC was also negatively correlated to CV-3 mm in the present study, but CC was not correlated to CV-5 mm, and was positively correlated to CV-7 mm, suggesting that the correlation of CC and CV may differ according to the area of interest.…”

Section: Discussionmentioning

confidence: 97%

Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Jiang,

Du,

Sun

et al. 2024

Sci Rep

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To investigate the associations between corneal curvature (CC) and other anterior segment biometrics in young myopic adults. In this retrospective multi-center study, 7893 young myopic adults were included. CC and other anterior segment biometrics were measured by Scheimpflug imaging (Pentacam). CC was defined as SimK at central 3 mm area, and other anterior segment biometrics included white-to-white corneal diameter (WTW), central corneal thickness (CCT), corneal volume (CV) at 3 mm, 5 mm, and 7 mm area, anterior corneal astigmatism (ACA), posterior corneal astigmatism (PCA), anterior corneal eccentricity (ACE) and asphericity (ACAP), posterior corneal eccentricity (PCE) and asphericity (PCAP), anterior chamber depth (ACD), and anterior chamber volume (ACV). Univariate regression analyses were used to assess the associations between CC and other anterior segment biometrics, and multivariate regression analyses were further performed to adjusted for age, gender and spherical equivalent. CC was higher in patients of female gender and higher myopia (all P < 0.05). Eyes in higher CC quartiles had lower WTW, thinner CCT, lower CV at 3 mm and 5 mm, lower ACD, and lower ACV (all P < 0.001), but had larger ACA, larger PCA, less PCE and less PCAP (all P < 0.001), compared to eyes in lower CC quartiles. The trends of CV at 7 mm, ACE and ACAP were inconsistent in different CC quartiles. After adjusting for age, gender and spherical equivalent with multivariate linear regression, CC was positively correlated to CV at 7 mm (βs = 0.069), ACA (βs = 0.194), PCA (βs = 0.187), ACE (βs = 0.072), PCAP (βs = 0.087), and ACD (βs = 0.027) (all P < 0.05), but was negatively correlated to WTW (βs = − 0.432), CCT (βs = − 0.087), CV-3 mm (βs = − 0.066), ACAP (βs = − 0.043), PCE (βs = − 0.062), and ACV (βs = − 0.188) (all P < 0.05). CC was associated with most of the other anterior segment biometrics in young myopic adults. These associations are important for better understanding of the interactions between different anterior segment structures in young myopic patients, and are also useful for the exploration of the pathogenesis of myopia.

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Section: Discussionmentioning

confidence: 97%

Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Jiang,

Du,

Sun

et al. 2024

Sci Rep

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“…16, No. 3, Mar.18, 2023 www.ijo.cn Tel: 8629-82245172 8629-82210956 Email: ijopress@163.com levels [13,33] , and CCT [10][11] affect IOP and they have different distribution among various communities. Considering the significant direct relationship between age and IOP observed in the present study, it seems that the older age range of study participants is the main reason for the higher mean IOP compared to previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported an increase [4][5] , some decrease [6][7] , and some no change [8][9] in IOP with advancing age. Since age influences many parameters affecting IOP, including corneal thickness [10][11] , blood pressure (BP) [12][13] , pulse [13][14] , and body mass index (BMI) [13][14][15] , the role of these parameters should be considered in the interpretation of the results. Sociodemographic and non-ocular factors are said to be responsible for 10% of IOP variations.…”

Section: Introductionmentioning

confidence: 99%

Distribution and associated factors of intraocular pressure in the older population: Tehran Geriatric Eye Study

Hashemi¹,

Aghamirsalim²,

Yekta³

et al. 2023

Int J Ophthalmol

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AIM: To determine the distribution and associated factors of intraocular pressure (IOP) in an Iranian elderly population 60 years of age and above. METHODS: The present report is part of the Tehran Geriatric Eye study (TGES), a population-based cross-sectional study that was conducted on the residents of Tehran 60 years of age and above. The sampling was performed using multistage stratified random cluster sampling methods from 22 districts of Tehran, Iran. Demographic and history information, blood samples, and blood pressure were collected from all participants. Ocular examinations included measurement of uncorrected and best-corrected visual acuity, objective and subjective refraction, and slit-lamp biomicroscopy. The IOP was measured using Goldmann applanation tonometry (GAT). Corneal imaging and ocular biometry were performed using Pentacam AXL. RESULTS: The data of 3892 eyes of 2124 individuals were analyzed for this report. The mean age of the study participants was 66.49±5.31y (range: 60 to 95y). The mean IOP was 15.2 mm Hg (95%CI: 15.1 to 15.4), 15.3 mm Hg (95%CI: 15.1 to 15.5) and 15.1 mm Hg (95%CI: 15.0 to 15.3) in all participants, males, and females, respectively. Of the study participants, 1.3% had an IOP of ≥20 mm Hg. The mean IOP increased from 15.1 mm Hg in the age group 60-64y to 16.3 mm Hg in the age group ≥80y. According to the final multiple GEE model, the IOP was statistically significantly higher in men than in women. All the studied age groups, except for the 75-79-year-old age group, had significantly higher IOP compared to the 60-64-year-old age group. The IOP was significantly higher in underweight compared to other body mass index groups. Moreover, the IOP had a statistically significant direct relationship with the mean corneal power (mean CP), central corneal thickness (CCT), and systolic blood pressure. CONCLUSION: The present study presents the distribution of IOP in an Iranian elderly population. A higher IOP (within the range 14 to 17 mm Hg) is significantly associated with older age, male sex, high systolic blood pressure, increased mean CP, and CCT. These factors should be considered in the clinical interpretation of IOP.

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The predictive value of anterior segment optical coherence tomography for postoperative corneal edema in cataract patients

Yan,

Li,

Wang

et al. 2024

Int Ophthalmol

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Central corneal thickness and its determinants in a geriatric population: a population-based study

Cited by 6 publications

References 64 publications

Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Distribution and associated factors of intraocular pressure in the older population: Tehran Geriatric Eye Study

The predictive value of anterior segment optical coherence tomography for postoperative corneal edema in cataract patients

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